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Showing 1 to 5 of 5 for “"NEIL2"”.

  1. Genetic determinants of NEIL2 transcription

    Carla Jean KinslowThe University of Texas Medical Branch2008

    … risk has been demonstrated by many studies. NEIL2 is a novel BER glycosylase that has been associated with transcription-coupled DNA repair and has a preference for oxidative products of cytosine. Because this enzyme is thought to be involved in transcription-coupled DNA repair, it could play …

    utmb Repository record

  2. RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE

    Little, Laura G

    … of three mammalian DNA glycosylases Neil1, Neil2, and Neil3. NEIL1 and NEIL2 are both able to recognize and cleave the oxidative lesion Sp in single stranded DNA in vitro. In duplex DNA, only NEIL1 is able to recognize and cleave the Sp lesion. A Neil1 -/- mouse model was recently developed …

    montana-tech Repository record

  3. RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE

    Little, Laura G

    … of three mammalian DNA glycosylases Neil1, Neil2, and Neil3. NEIL1 and NEIL2 are both able to recognize and cleave the oxidative lesion Sp in single stranded DNA in vitro. In duplex DNA, only NEIL1 is able to recognize and cleave the Sp lesion. A Neil1 -/- mouse model was recently developed …

    montana Repository record

  4. Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma

    Odufuwa, K2026

    … of the base excision repair genes Neil1, Neil2, Neil3, Ogg1, and Nthl1, the nucleotide excision repair gene Ercc1 and the mismatch repair gene Mlh1 in colorectal cancer (CRC) tumours and matched normal colon tissue. The project was then extended to analyse a further sixteen colon samples …

    salford Repository record

  5. Replication-associated base excision repair Of oxidized bases in the mammalian genome

    Corey Allen TheriotThe University of Texas Medical Branch2009

    … OGG1 and NTH1 in the Nth family, and NEIL1 and NEIL2 in the Nei family, with overlapping substrate range initiate BER by excising oxidized base lesions and cleaving the DNA strand. NEIL1 prefers oxidized pyrimidines or ring-opened purines as substrates and is upregulated at the mRNA and protein …

    utmb Repository record