Global ETD Search
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Showing 1 to 6 of 6 for “"NEIL1"”.
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RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE
… product of these further oxidative events. The NEIL1 base excision repair (BER) glycosylase has been shown to recognize and cleave the oxidative DNA lesion Sp. NEIL1 belongs to a family of three mammalian DNA glycosylases Neil1, Neil2, and Neil3. NEIL1 and NEIL2 are both able to recognize and …
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RESPONSE OF A NEIL1 DEFICIENT MURINE EPITHELIAL CELL LINE TO CHROMATE
… product of these further oxidative events. The NEIL1 base excision repair (BER) glycosylase has been shown to recognize and cleave the oxidative DNA lesion Sp. NEIL1 belongs to a family of three mammalian DNA glycosylases Neil1, Neil2, and Neil3. NEIL1 and NEIL2 are both able to recognize and …
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Replication-associated base excision repair Of oxidized bases in the mammalian genome
… namely, OGG1 and NTH1 in the Nth family, and NEIL1 and NEIL2 in the Nei family, with overlapping substrate range initiate BER by excising oxidized base lesions and cleaving the DNA strand. NEIL1 prefers oxidized pyrimidines or ring-opened purines as substrates and is upregulated at the mRNA …
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… glycosylases (endonuclease VIII – like 1 & 3 [NEIL1 & NEIL3]) that excise oxidised bases from DNA, thus initiating base excision repair, have been found to participate in the resolution of psoralen induced ICLs. Therefore, this project set out to determine whether the modulation of NEIL1 or …
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The role of the human endonuclease VIII-like 1 and 3 in the repair of DNA replication blocking lesions
… (ICLs), arising from exogenous agents. Human NEIL1 (hNEIL1) activity on psoralen generated mono-adducts (MAs) and three-stranded DNA ICLs was previously described and recently NEIL3 from Xenopus laevis was reported to repair psoralen generated MAs and apurinic/apyrimidinic site DNA ICLs. Here, …
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Gene expression of DNA repair proteins in colorectal cancer and medulloblastoma
… patterns of the base excision repair genes Neil1, Neil2, Neil3, Ogg1, and Nthl1, the nucleotide excision repair gene Ercc1 and the mismatch repair gene Mlh1 in colorectal cancer (CRC) tumours and matched normal colon tissue. The project was then extended to analyse a further sixteen colon …