Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"NEDD9"”.
-
The role of NEDD9 in TGFβ mediated tumour initiating cell dynamics in the Claudin-low breast cancer subtype
… through the ability of the scaffolding protein NEDD9 to unite the TGFβ/SMAD and Rho-Actin-SRF pathways. Previously, oncogenicity has been ascribed to the level of NEDD9 protein expression. However, my analysis indicates this mediation by NEDD9 is irrespective of NEDD9 protein expression, which …
-
Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… Zellen spielen, wie Gata2, Runx1, Id3 und Nedd9. Die nähere Untersuchung der Auswirkungen eines Funktionsverlustes der Zielgene Ctgf, Gata2, Runx1 und Nedd9 auf die TGF-β induzierte Neurogenese identifizierte Nedd9 als notwendige Signal-Komponente während dieses Prozesses. Die Expression …
-
EBV-Associated Gastric Cancer: From Initial Infection to Unique Therapeutic Approaches
… mutant gastric cancers. I found that loss of NEDD9 or inhibition of BCL-XL rendered cells hyper-sensitive to the PI3Ka inhibitor BYL719. Additionally, I found that loss of CBFB conferred resistance to BYL719 through up- regulation of the protein kinase PIM1 and defined the clinical utility of …
-
Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies
… in gastric cancer may be mediated by BCL-xL and NEDD9. Sensitization to PI3K-alpha inhibition by BCL-xL specific inhibitor revealed a novel targeted approach for the treatment of EBV+ PIK3CA mutant gastric cancers, thereby overcoming a perplexing obstacle to the effective targeting of PI3K …