Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"NEDD4L"”.
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Investigating the Influence of NEDD4L in the Development of Salt Sensitive Hypertension with Age
… in the hypertensive population. The NEDD4-like (NEDD4L) protein is important in sodium reabsorption and has been implicated in essential hypertension and salt sensitivity. Objectives: Two variations (rs4149601/rs2288774) found in NEDD4L have been associated with salt sensitivity and hypertension; …
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Pharmacogenetics of resistant hypertension: evaluating the role of genetic variation in ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B among South African hypertensive patient
… namely, ABCB1, ADBR1, CES1, CYP3A4, CYP3A5, NEDD4L, NOS3, NR3C2 and SCNN1B, in the development of resistant hypertension in South African patients. Knowledge of pharmacogenetic variants that play a role in resistant hypertension may potentially improve treatment and management of hypertension …
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Genetic Factors and Dietary Salt Intake as Determinants of Blood Pressure and Risk of Primary Hypertension
… Developmentally Down regulated 4 like gene (NEDD4L)) (study III-V); (iii) investigate the role of dietary salt restriction on BP as well as to explore the possibility to predict this BP change by measuring plasma concentrations of renin (P-renin) and N-terminal pro-Atrial Natriuretic Peptide …
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The relationship between reduced renal function and cardiovascular disease
… a renal sodium channel (ENaC) remover/regulator (NEDD4L) to the 6-month blood pressure lowering effect and risk of CVD in patients treated with β-blockers and/or thiazide diuretics and in patients treated with the Ca+-channel blocker diltiazem. In patients with hypertension, creatinine and CG …
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The Genetics of Type 2 Diabetic End-Stage Renal Disease in African Americans
… in AA cases with T2DM-ESRD and AA controls. NEDD4L and SERPINB7 were identified as T2DM-ESRD candidate genes in AA. In order to evaluate genetic variations across the entire genome that may contribute to T2DM-ESRD risk in AAs, a genome-wide association study (GWAS) was conducted. Following a …
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Targeted Degradation of Intracellular Proteins using Ubiquitin Variant Induced Proximity
… UbVIP to recruit the E3 ligases RFWD3 and NEDD4L. Chapter 3 investigates the effectiveness of recruiting the E2 conjugating enzyme, UBE2B, in degrading target proteins. Collectively, the findings from this research shed light on a peptide-based targeted protein degradation strategy and …
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Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Regulates Host Gene Expression and Post-Translational Modifications Determine its Localization and Function
… during infection by the host E3 Ub ligase NEDD4L. When TRP32 poly-ubiquitin chains were examined by immunoblotting K63-linked chains were detected but not K48 or K11-linked chains and TRP32 was not responsive to treatment with the proteasome inhibitor carfilzomib. An electromobility shift …