Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"NCI-H838"”.
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Identification and evaluation of the bioactive peptide QUB-2925 from the defensive skin secretion of Phyllomedusa tomopterna
… significantly inhibited the proliferation of NCI-H838 cells at a concentration of 10-5 M, with an inhibition of 80.1%. Also, it showed haemolytic activity with 8.5% haemolysis at 64 μM. In conclusion, QUB-2925 showed obvious antibacterial activity against E. coli, S. aureus and C. albicans at …
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Identification and functional study of a novel bioactive peptide QUB-1761 from the venom of the Brazilian yellow scorpion, Tityus serrulatus
… can completely kill the human lung cancer cells (NCI-H838). In terms of the haemolytic assays, QUB-1761 showed about 30% haemolysis activity at 64 µM and more than 50% at 128 µM. Nonetheless, QUB-1761 has the potential to be used in the design of drugs to treat bacterial infections or cancer if …
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Identification and functional evaluation of a bioactive peptide QUB-2669 from the skin secretion of the American bullfrog Lithobates catesbeiana
… effects against the cancer cell line NCI H838 at a concentration of 10-4 M. Besides, the haemolytic activity of QUB-2669 was lower than 20 % at the concentration range from 1 μM to 16 μM. Compared with QUB-2669, MetO-QUB-2669 showed lower antimicrobial, antiproliferative and haemolytic …
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Identification and characterisation of a novel antimicrobial peptide from the defensive skin secretion of the Heilongjiang brown frog, Rana amurensis
… combination of molecular cloning and Sanger sequencing. Then bioactivity of the peptide was evaluated through using antimicrobial assays, antiproliferative assays and haemolysis assay. It was found to inhibit the growth of E. coli (MIC=2µM), S. aureus (MIC=16µM), and C. albicans (MIC=64µM). It …
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Identification and functional study of the bioactive peptide QUB-2417 from the skin secretion of the tree frog, Phyllomedusa bicolor
… bioactivity against lung cancer cell line NCI-H838 at the highest test concentration (10-4 M) and the value of IC50 was 35.3 µM. In the haemolysis bioassay, QUB-2417 exhibited about 30% haemolytic effect at the highest test concentration (128 μM) and the value of HC50 was 690 µM. Hence, the …
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Identification, isolation and bioactivity assessment of a bioactive peptide QUB-2339 from the skin secretion of the Hainan sucker frog, Amolops hainanensis
… at 100 μM against lung cancer cell line (NCI-H838). However, the haemolytic rate of QUB-2339 was relatively high, which was more than 10%, when the concentration was above 16 μM. So it needs to be modified to decrease its toxicity before further development progresses.
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Identification and functional study of the antimicrobial peptide, QUB- 1985, from the skin secretion of the large odorous frog, Odorrana livida
… activity on non-small cell lung cancer cells (NCI-H838) at concentrations of 10-5 M and above, and the IC50 was 1.470×10-5 M. From the above, QUB-1985 is competent to become an antimicrobial lead compound, especially towards Gram-negative bacteria and its anti-proliferation activity may broaden …
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Identification and functional study of the bioactive peptide QUB-2830 from the skin secretion of the blue-side leaf frog, Agalychnis annae
… shown to have antiproliferation activity against NCI-H838 cancer cells at a concentration of 10-4 M. In a haemolysis assay, QUB-2830 showed haemolytic activity at concentrations between 16 ~ 128 μM. In summary, QUB-2830 exhibited a remarkable antimicrobial ability and may be expected to become a …