Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"NCAM"”.
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Improving dopamine monitoring with NCAM and the effects of intranasal oxytocin on dopamine signaling in the rat brain
… of DA signals. Neural cell adhesion molecule (NCAM) may reduce gliosis and potentially improve the ability of FSCV electrodes to monitor DA signaling. Chapter 1 Methods: FSCV electrodes were coated with NCAM and implanted in the rat brain. Non-NCAM coated electrodes were implanted in the …
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Mechanism of the Neural Cell Adhesion Molecule and Mode of Polysialic Acid Adhesive Inhibition
… measurements are presented on polysialylated NCAM proteins to determine the effects of polysialic acid on both NCAM and C-cadherin mediated adhesion. Results indicate that polysialic acid inhibits both NCAM and cadherin adhesion by increasing the intermembrane repulsion. This inhibitory effect …
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Design, Synthesis and Biological Evaluation of Inhibitors of Polysialyltransferases PST and STX. Design, synthesis and biological evaluation of a range of N-modified mannosamines, sialic acids and analogues from in silico screening as inhibitors of PolySia-NCAM biosynthesis with anti-migration activity.
Polysialylated NCAM (polySia-NCAM) is re-expressed in a number of tumours, including small cell lung carcinoma and neuroblastoma and is strongly associated with aggressive, invasive and metastatic tumours in the clinic. SiRNA knockdown of the polysialyltransferases (polySTs), the enzymes …
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The Manipulation Of Apical Dendritic Plasticity And The Consequences For The Effects of Chronic Stress
… with endo N, an enzyme that cleaves PSA from NCAM for at least 30 days. PSA-NCAM is a cell adhesion molecule present during plasticity in development and also following chronic stress in the hippocampus. PSA-NCAM removal did not cause cell death on its own or following chronic stress by …
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Probing Biological Systems at the Single Molecule Level: Studies of the Homophilic Binding of the Neural Cell Adhesion Molecule (Ncam) and Phase Dependent Lipid Anchorage Strength
Force probe measurements were also used to study environmental effects on the intermolecular strength of lipids within a membrane. In this case the anchorage strength of lipids in fluid versus gel lipid layers was probed to determine how temperature affects the adhesion properties between adjacent …
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Pharmacological evaluation of the inhibition of polysialyltransferases as a therapeutic strategy in cancer. Characterisation of models for evaluating polysialic acid as a potential therapeutic target and pharmacological assessment of novel polysialyltransferase inhibitors
… of the neural cell adhesion molecule (PSANCAM). PSA-NCAM is selectively re-expressed in a number of tumours including neuroblastoma, where it is thought to modulate tumour dissemination. Expression is strongly associated with poor clinical prognosis and an aggressive tumour phenotype. …
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Biofunctionalization of Submicrometer Pores and Mass Limited Sample Manipulations in Three-Dimensional Hybrid Microfluidic/nanofluidic Devices
… binding) of antibody on the inner walls of the NCAM. Selective capture and release of the specific analyte using the Fab' modified NCAM are demonstrated offline using scanning electron microscopy and matrix-assisted laser desorption/ionization (MALDI) with time-of-flight mass spectrometry …
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Stress and Hippocampal Plasticity
… acid neural cell adhesion molecule (PSA-NCAM) expression and neuronal excitability. In addition, the learning and memory process is dissected using a contextual fear conditioning paradigm in order to identify the component that can affect hippocampal cell proliferation. The results …
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Molecular Mechanisms of Cell Adhesion
NCAM forms a complex between its terminal domains Ig1 and Ig2. When NCAM of cell A and cell B connect to each other through complexes Ig12(A)/Ig12(B), the relative mobility of cells A and B and membrane tension exerts a force on the Ig12(A)/Ig12(B) complex. Here we investigate the response of the …
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Molecular characterization of three mental illness susceptibility genes
… on three candidate genes: NRG1, ST8SIA2 and NCAM1, each associated with psychotic mental illness, and determine how these genes could be functionally involved in disease susceptibility. Working with case-control cohorts, analysis of the target genes was undertaken at the DNA, RNA and protein …
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Connexin-32 and Connexin-43 Immunoreactivity in Rodent Taste Buds
… in nerve fibers and in a small subset of NCAM–LIR cells. Connexin–32–LIR does not co–localize with α–gustducin–LIR or PLCβ2–LIR. We observed that connexin–43–LIR is present in a subset of PLCβ2–LIR cells and in a subset of α–gustducin–LIR cells. Connexin–43–LIR does not co–localize with …
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Synthesis of inhibitors of polysialyltransferases PST and STX. Development of routes to synthesis, preparation and purification of carbohydrate and carbacycle-based potential inhibitors of the polysialyltransferase enzymes PST and STX
… acids and a posttranslational modification of NCAM (neural cell adhesion molecule), biosynthesized by combined action of two polysialyltransferase enzymes, ST8SiaIV(PST) and ST8SiaII(STX). PolySia alters NCAM-dependent cell adhesion that is crucial for the CNS development. In adulthood, polySia …
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Energy analysis and fabrication of photovoltaic thermal water electrolyzer and ion transport through modified nanoporous membranes
… disodium salt (NDS2-), using a conductive NCAM. A polycarbonate track etched (PCTE) membrane was made conductive by sputter coating gold on the membrane surface. Transport studies were done in a voltage range in which faradaic current was minimized at the surface of the gold-coated NCAMs. …
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Colloidal Gold as Molecular Capture Devices in Hybrid Nano/microfluidic Systems for Mass-Limited Sample Analysis
… dimensions. A nanocapillary array membrane (NCAM) was utilized to enable efficient mixing of the gold colloid and the adsorbate in-device. Fluorescence microscopy was used to monitor fluorescence quenching during monolayer self-assembly of analytes on the colloidal gold surface. The kinetics …
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Sex differences in the development of the splenium of the rat corpus callosum
… the end of the second postnatal week. Embryonic NCAM was present in the splenium from postnatal day 9 through young adulthood. Because the persistent expression of e-NCAM in adult animals has been associated with brain regions capable of structural plasticity, the splenium of the rat corpus …
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Expression von Zytokinrezeptoren, Adhäsionsmolekülen und kostimulatorischen Molekülen und deren klinische Relevanz bei der akuten myeloischen Leukämie
… LFA-3 (CD58), B7-1 (CD80), B7-2 (CD87) und NCAM (CD58). Eine KM-Probe wurde als positiv gewertet, wenn mehr als 20% der Blasten im Auswertefenster den entsprechenden Marker exprimierten. Ergebnisse: Der durchschnittliche Anteil Zytokinrezeptoren exprimierender Zellen war in KM-Proben von …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
… mRNA was expressed in astrocytes and microglia. NCAM mRNA was expressed in astrocytes as well as neurons and CHL1 mRNA is expressed in astrocytes, microglia and neurons. And L1 mRNA was expressed in neurons. As the result of the expression of altered CAMs mRNA against to injuries, ICAM-1 mRNA …
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Influence of Extracellular Matrix Stiffness and Topography on Neuronal Cell Behavior and Neurite Outgrowth
… integrin and neural cellular adhesion molecule (NCAM). Results show that by increasing the ECM stiffness, the neuronal cell transfers higher stress to the ECM, known as mechanosensing. The mechanosensing, however, approaches saturation at a threshold ECM stiffness and is impacted by ECM …
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