Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"NBQX"”.
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A Single Alcohol Pre-exposure Alters Dorsolateral Striatal AMPA Receptor Dependent Binge and Compulsive-like Drinking
… infusion of one of three concentrations of NBQX, an AMPA receptor antagonist, into the DLS, immediately prior to DID where the DID solution was either alcohol or QuA. Results We found that three weeks, not two, is sufficient to produce robust compulsive-like QuA drinking in C57BL/6J mice. We …
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Mechanisms of rapid receptive field reorganization in rat spinal cord
… in 9 of 20 (45%) tested cells. Application of NBQX produced no effect on either original or expanded RFs indicate that RF shrinkage effects of glutamate involve NMDA receptors. The results are consistent with the prediction of the proposed model. Subcutaneous injection of capsaicin into tactile …
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The role of ionotropic glutamate receptors in chronic central pain after spinal cord injury
… glutamate antagonist treatment (D-AP5 or NBQX). The thoracic cord, which is nearest to the site of injury, showed the greatest increase in ionotropic glutamate receptor mediated activity. \r\n Calcium-calmodulin protein kinase II (CaMKII) has been shown to be responsible for enhancing …
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Neuroadaptive Changes in the Mesocortical Glutamatergic System during Nicotine Self-administration and after Extinction in Rats
… or sucrose SA on d 19. In contrast, in VTA, NBQX, an AMPA-R antagonist, attenuated both nicotine and sucrose SA. In summary, chronic nicotine SA amplified both mPFC and VTA glutamate responses to mPFC NMDA. This hyper-responsiveness, along with the up-regulation of glutamate receptors, …
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Roles of interleukin-1 beta in glutamate-induced spinal cord injury
… NMDA receptors on IL-1â and IL-1ra, MK801 and NBQX were applied individually on the spinal cord with glutamate. The results show that both AMPA and NMDA receptors are involved in glutamate-induced reciprocity between IL-1â and IL-1ra. To determine if this reciprocity between the expression of …
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A neurophysiological and proteomic study of cognitive enhancing strategies
… events following application of 4-AP and NBQX into continuous beta frequency oscillations. This action is not mediated by the M1 mAChR. Thus selective M¬1 mAChR display a preferable range of oscillatory activities compared to non-subtype selective mAChR agonists. Ampakines are a further …
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Investigation of the functional effects of two novel ampakines in the CNS
… the potent selective AMPA receptor antagonist, NBQX (10 mg/kg), which itself had minimal effects on LCGU. These data provide an anatomical basis for the cerebral activation induced by these compounds, which are directly AMPA receptor mediated. Areas activated also closely correlated with brain …
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Study of the etiology of neurolathyrism, a human neurodegenerative disease with nutritional causes
… ,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide (NBQX) or the Ca2+-permeable AMPA-receptor antagonist 1-naphthyl acetyl-spermine (NAS) prevented L-β-ODAP or L-glutamateinduced cell death. Similarly, inclusion of the antioxidants Met or Cys in the treatment medium protected the neurons from …