Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"NBD1"”.
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The CFTR Folding Pathway: Implications for the Identification and Development of CF Therapeutics
… F508 is located in Nucleotide Binding Domain 1 (NBD1) and is predicted to be at the interface with Intracellular Loop 4 (ICL4) of Transmembrane Domain 2 (TMD2). Studies of the isolated NBD1 demonstrate that the ΔF508 mutation impacts the folding pathway and stability of the domain. Misfolding of …
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Structure-Function Studies on Human Epithelial Cystic Fibrosis Chloride Channels Expressed in Xenopus Laevis Oocytes
… domains, two nucleotide binding domains (NBD1, NBD2) and a regulatory (R) domain. Channel gating is controlled by R-domain phosphorylation and by ATP binding and/or hydroysis at the NBDs. Exon 13 of the CFTR gene encodes residues 590 to 830, originally ascribed to the R domain. Here, CFTR …
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The CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Channel: Anion Permeation, and Regulation by Adenylyl Cyclase and ATP Hydrolysis
… channels can bind and hydrolyze ATP only at NBD1, resulting in exclusively brief channel openings. Fully phosphorylated channels can bind and hydrolyze ATP at both NBD1 and NBD2: hydrolysis at NBD1 opens channels, and binding of ATP at NBD2 stabilizes the channel in the open conformation, …