Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"NBD"”.
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A Recency-Only Pareto/NBD
… paper will examine an extension to the Pareto/NBD model commonly used in customer base analysis. The paper will demonstrate and estimate a "recency-only" version of the Pareto/NBD. The model will be fit to both real-world and simulated data and will be compared to the "recency/frequency" model. …
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Towards sustainable heterogenous catalysis in molecular solar thermal energy storage (MOST) systems
… isomeric couple known as norbornadiene (NBD) and quadricyclane (QC). Despite the recent resurgence in MOST systems, triggering the back-reaction utilising heterogenous catalysts remains scarcely investigated. This thesis is divided into two introductory chapters, four principal chapters …
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Synthesis and Characterization of I. Organometallic Amidophenolate Complexes II. Cyanometallate Frameworks
… The complexes Pt(tBAFPh)(COD), Pt(tBAFPh)(nbd), and Pt(O2C 6H2tBu2)(COD) (H2tBA FPh = 2-(2-trifluoromethyl)anilino-4,6-di-tert-butylphenol) were examined by cyclic voltammetry. The complexes with amidophenolate ligands displayed milder redox potentials than their catecholate analogues. …
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Mechanistic studies of ABC transporters
… (TMDs) and two nucleotide binding domains (NBDs) locating at the cytoplasmic side of the membrane. While the TMDs provide the pathway for substrate translocation and are highly variable among different subfamilies, the NBDs provide the power source of the active transport and are highly …
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… IKKγ/NEMO. This highlighted a novel role of the NBD as a multi-protein docking site. Binding of these proteins was further confirmed endogenously in a cellular setting, by means of co-immunoprecipitation and also the kinetic profiles of these interactions were characterised using recombinant …
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Structure-based Design of Small Molecule Inhibitors of HIV-1 Entry
… cavity in gp120 based on a previous CD4-mimetic, NBD-556. By either soaking or co-crystallizing the newly designed compounds bound to gp120, we were able to solve four x-ray crystal structures in order to observe the interactions with the binding cavity on the atomic level. Using x-ray crystal …
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Properties of two modified moment estimators for parameters of the negative binomial distribution
… of the negative binomial distribution (NBD). Several parametric forms have been suggested for the NBD. The estimation problems vary according to the form which is used. In particular, the form proposed by Anscombe [Biometrika, 37 (1950), pp. 358-382), with parameters λ and α, has …
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Regulation of P-glycoprotein at the Blood-Brain Barrier
… of the fluorescent, P-gp-specific substrate, NBD-cyclosporine A (NBD-CSA), in the lumens of isolated rat brain capillaries using confocal microscopy and quantitative image analysis. Exposing capillaries to the hormone endothelin-1 (ET-1) rapidly and reversibly reduced luminal NBD-CSA …
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Insights into the mechanism of action of quinoline antimalarials against Plasmodium falciparum revealed by novel fluorescent analogues and chemical proteomics
… click reduction. 7-Nitrobenz-2-oxa-1,3-diazole (NBD) was identified as a suitable reporter fluorophore and was attached to the quinoline core by nucleophilic aromatic substitution. The length of the spacer chain between the quinoline and the fluorophore was varied by preparing NBD-labelled amino …
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In cellulo and biophysical exploration of the role of GGMP residues of Hsp70
… domain (SBD) and nucleotide binding domain (NBD). The NBD of Hsp70 is responsible for its ATPase activity. Some Hsp70s of parasites particularly those of apicomplexa are marked by GGMP residues. For example, Plasmodium falciparum Hsp70-1 (PfHsp70-1) which occurs in the cytosol and nucleus …
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X-Ray and Neutron Scattering Studies of Niobium-Hydrogen Alloys Near the Alpha-Prime to Beta Phase Transition
An experimental study of NbD(,x)(H(,x)) alloys (0.70 < x < 0.85) in the vicinity of the (alpha)'-(beta) phase transition was conducted using x-ray and elastic neutron scattering techniques in the temperature range 300 < T < 473 K. Diffuse scattering close to the Bragg peaks of the BCC (alpha)' …
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Deciphering Functional Significance of Substrate-Binding Domain of Ssa1 on Heat-Shock Response and Prion Propagation
… of two domains: nucleotide-binding domain (NBD) and substrate-binding domain (SBD). In this work, a well-established yeast system and a combination of computational biology, genetics, structural biology, biochemistry and molecular biology were utilized to decipher the role of the SBD of …
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The Effects of the Mad Dog Diet on Bowel Function, Body Composition, Neuropathic Pain, and Depression in a Spinal Cord Injury and Multiple Sclerosis Population
… (SCI-QOL) and Neurological Bowel Dysfunction (NBD) questionnaires, body composition was assessed via dual-energy X-ray absorptiometry (DXA) scans, neuropathic pain was assessed via the neuropathic pain questionnaire, and depression was measured via the Center for Epidemiologic Studies …
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Drug Design, Biological Activity, and Metabolic Consequences of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging to Understand Drug Action and Metabolism
… and introduce the use of novel Platinum-NBD fluorescent conjugates as probes for drug metabolism. In the second project we report the design, synthesis, and biological consequences of fluorescent drug derivatives based on the NBD fluorophore, for use in understanding drug action and drug …
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Improved Synthesis, Separation, Transition Metal Coordination and Reaction Chemistry of a New Binucleating Tetraphosphine Ligand
… reacts with 2 equiv of PtCl2(cod) or [Rh(nbd)2](BF4) to give bimetallic Pt2Cl4(rac-et,pt-P4-Ph), 4R and [rac-Rh2(nbd)2(et,ph-P4)](BF4)2, 6R, in which et,ph-P4-Ph acts as a bridging and chelating ligand. Heterobimetallic complex, NiPtCl4(rac-et,pt-P4-Ph), 5R has been prepared by reaction of …
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Synthesis of fluorescent analogues of a-tocopherol as ligands for the human a-tocopherol transfer protein (a-TTP) /
… 2a-d [w-nitro benzoxadiazole-a-tocopherols, NBD-aToes], 3a-d [w-dansyl-a-tocopherols, DAN-a-Toes], and 4a-d [w-N-methylanthranilamide-atocopherols, NMA-a-TocsD were prepared by substituting fluorescent labels at the terminus of w-functionalized alkyl chains extending from C-2 of the chroman …
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Mechanism of Action Studies of Phenotypic Whole-cell Active Antimalarial Leads Through Target Identification
… in this series. 7-Nitrobenz-2-oxa-1,3-diazole (NBD) was identified as an appropriate external fluorophore and was attached to the compounds investigated. The spacer chain length between the compounds and the fluorophore was varied to find suitable fluorescent derivatives that would appropriately …
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Spectroscopic and synthetic studies relating to a dirhodium hydroformylation catalyst
… hydroformylation catalyst, rac-[Rh<sub>2</sub>(nbd)<sub>2</sub>(et,ph-P4)](BF<sub>4</sub>)<sub>2</sub>, and to fully identify the catalytically inactive mono- and dirhodium complexes formed upon fragmentation of the catalyst under hydroformylation conditions. Various in situ NMR methods such as …
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Mechanism of tocopherol transfer by human α-tocopherol transfer protein (α-hTTP)
… Using a fluorescently labelled a-tocopherol (NBD-a-Toc) synthesized in our laboratory, a fluorescence resonance energy transfer (FRET) assay was developed to monitor the kinetics of ligand transfer by a-hTTP in lipid vesicles. Preliminary results implied that NBD-a-Toe simply diffused from …
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Factors affecting the binding of lecithin:cholesterol acyltransferase with interfacial substrates
… transfer from DNS-LCAT to rHDL labeled with NBD-stearate; direct binding of $\sp{125}$I-LCAT to microtiter plates coated with rHDL; and an activity inhibition assay. Using these methods, LCAT binding affinity was demonstrated to be independent of apolipoprotein composition, indicating that …
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