Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 108 for “"NAV"”.
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… factor critical for the maintenance of the Nav complex, in neurons is controlled via a GSK-3 dependent signaling pathway (Shavkunov et al., 2013). Additionally, inhibition of GSK-3 reduces the assembly of FGF14:Nav1.2 complexes, redistributes FGF14 and Nav channels from the axonal …
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Factors that impact on South African REITs trading at a discount or premium to their NAV
… a discount or premium to their net asset value (NAV), known as the NAV spread. Globally, REITs have become an increasingly popular means for investing in real estate representing 41% of the global listed property industry and reaching a total market capitalisation of US$ 1.3 trillion as at June …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
Voltage-gated sodium (Nav) channels are responsible for initiation and propagation of action potentials, which contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with a wide range of brain disorders including psychological, neurological and …
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Identifying Protein Interactors of Voltage-Gated Sodium Channel Nav1.6 in Native Tissue
Voltage-gated sodium (Nav) channels play a critical role in the initiation and propagation of action potentials in excitable cells and are involved in numerous neurological diseases such as epilepsy, neuropathic pain, and cancer. Although approved drugs targeting Nav channels are available, they …
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Regulation of signaling and function of the voltage-gated sodium channel complex by protein:protein interactions
… of neuronal function, voltage-gated Na+ (Nav) channels are important targets for therapeutic development against a wide range of health conditions. Dysfunction of Nav channels in the CNS is associated with disorders ranging from neurological (i.e., epilepsy, neurodegeneration) to …
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Impacto de la neumonía asociada a ventilación mecánica en el traumatismo cráneo encefálico grave
… (medida por días de estancia y días de VM) de la NAV en un colectivo de 144 pacientes con traumatismo craneoencefálico grave. Objetivo. Investigar la influencia sobre la mortalidad y morbilidad de la neumonía nosocomial en pacientes con traumatismo craneoencefálico grave. Con los fundamentos …
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Resultados en reducción abierta de cadera por via interna: necrosis avascular y concordancia interobservador
… los criterios de Salter de necrosis avascular (NAV), con un seguimiento mínimo de 18 meses. Se evaluó la concordancia interobservador para la clasificación de Salter en tres ortopedistas infantiles. Resultados Se evaluaron 20 caderas en 16 pacientes a los que se realizo reducción abierta de …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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Exploring mechanisms of inhibition and inactivation in voltage-gated sodium channels using molecular simulations
Voltage-gated sodium (Nav) channels play a pivotal role in the conduction of electrical signals across the human body, with different subtypes expressed across excitable tissue in the brain, heart and muscle. Nav channels transiently form transmembrane pores by cycling through the closed, open and …
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Desenlaces de las infecciones respiratorias en la unidad de cuidado intensivo de la fundación neumologica colombiana
… (UCI). Existen dos infecciones: neumonía (NAV) y traqueobronquitis (TAV). NAV genera impacto negativo en los desenlaces de los pacientes al aumentar la morbilidad, mortalidad y los tiempos en UCI y VM, pero no se conoce el impacto de TAV. El objetivo de este estudio fue identificar si hay …
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Sodium channel diversity in the vestibular ganglion : evidence for Nav̳1.5-like and Nav̳1.8-like currents
Voltage-gated sodium (Nav) channels are diverse, comprising nine known mammalian subunits, which are classified pharmacologically into tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-insensitive (TTX-1) categories. The pattern of Nav channel expression shapes response properties of neurons, while …
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Simultaneous DTI and rs-fMRI using the navigated diffusion sequence
… volume acquisition (hereafter called the single nav sequence), modified to acquire BOLD resting state fMRI (rs-fMRI) data. We also investigated inserting a second 3D EPI acquisition in the middle of each DTI volume acquisition (hereafter called the double nav sequence) to increase fMRI temporal …
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Factors associated to avascular necrosis of the femoral head and non-union in patients younger than 65 years old with displaced femoral neck fractures treated with reduction and internal fixation.
… evaluados. Los pacientes que desarrollaron NAV fueron significativamente mayores y sufrieron un trauma de más baja energía que en los casos sin AVN. Ninguna variable fue asociada con la no-unión. La regresión logística determinó que sólo la edad se asoció de forma independiente a NAV. La …
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Structural and functional role of the extracellular loops and C-terminal domain of the voltage-gated sodium ion channel
Voltage-gated sodium ion channels (Nav) are central to action potential initiation through regulating the entry of sodium ions (Na+) into excitable cells including cardiomyocytes and neurones. The α-subunit of Nav consists of four homologous domains (DI-DIV), each consisting of six transmembrane …
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The determinants of REIT franchise value : a reprise
… defined as the Premium-to-Net Asset Value (NAV) at which most REITs trade. In broader terms, franchise value is often defined as the present value which management is expected to add in terms of net revenue growth to shareholders. A more specific definition of franchise value was presented …
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A sensitivity study of bow variants on the distribution of sea spray in regular head seas
Thesis (Nav. E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1990.
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An integrated hydrofoil and propeller design tool for Windows environment
Thesis (Nav. E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1996.
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Dynamic simulation of shipboard electric power systems
Thesis (Nav. E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1993.
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Vibration reduction of marine cable systems using dynamic absorbers
Thesis (Nav. E.)--Massachusetts Institute of Technology, Dept. of Ocean Engineering, 1996.
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