Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"NATURAL SCIENCES::Biology"”.
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The role of semaphorin 3A signaling underlying learning and memory formation in the postnatal mouse brain
Memory formation is largely mediated by changes to synapses, which are sites of communication found between neurons. Currently, the dominant experimental model that describes the cellular changes that occur during learning and memory is known as long-term potentiation (LTP). While some of the …
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Nematodes as indicators of sustainable soil health management practices in corn-soybean production
Soil nematodes are multicellular organisms causing significant economic and ecological impacts, and their community composition is widely used as a bioindicator of soil health. Current methodologies for nematode assessment require further refinement and advancement. This thesis addressed knowledge …
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Physiological Oxygen and Media Conditions Influence Breast Cancer Hallmarks in Vitro
Standard cell culture conditions often fail to replicate the in vivo microenvironment, limiting the reproducibility and physiological relevance of experimental findings. For example, commonly used media such as Dulbecco’s Modified Eagle Medium (DMEM) contain supraphysiological levels of key …
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Investigating β- and γ-secretase function and processing of APP with genetic and pharmacological tools
The sequential cleavage of Amyloid Precursor Protein (APP) by BACE1 and the gamma secretase complex (γS) generates amyloid-beta (Aβ), a small peptide that is highly implicated in the pathogenesis of Alzheimer’s Disease. Despite decades of research, there remains a lack of understanding of the …
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The impact of acute heat exposure on the heat shock response (HSR) between males and females
While acute heat stress induces genomic changes in immune cells of young adults, the influence of ovarian hormones on the molecular response remains unclear, despite their documented role in thermoregulation. This study investigated the molecular response to acute heat stress in males (n=11), …
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Investigating the effects of aging and the neuromodulator retinoic acid on neurite outgrowth in a novel CNS organ culture
Neurite outgrowth is a critical process for nervous system regeneration following injury. However, aging impairs this process through changes in calcium handling, neurotransmitter sensitivity, and energy metabolism. In this thesis, I investigated agerelated changes in neurite outgrowth using a …
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Effects of exemplary teaching and learning materials on students performance in biology
… on students' participation and achievement in biology in Botswana science classrooms. In particular, it was concerned with examining the effects of student-teacher-material interactions on the students' participation and achievement in biology. The method adopted for this study was an eclectic …
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Apoptotic markers in ejaculated human spermatozoa
The role of male germ cell death in spermatogenesis is an important one as it removes dysfunctional or genetically damaged germ cells and is necessary to maintain an optimal germ cell to Sertoli cell ratio. The formation of the bloodtestis barrier requires the elimination of excessive germ cells …
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Genome-wide microscopy screening identifies links across processes including a conserved connection between DNA damage control and the microtubule cytoskeleton
Previous PhD students in the lab created a method for large-scale, high-content microscopy screening of a cell library consisting of over 3000 single mutant strains of the fission yeast, Schizosaccharomyces pombe. Each strain has one nonessential gene knocked-out, allowing investigation of the …
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Graph Attention Mechanisms for Modeling Pathway-Level Importance from Gene Expression
… of the complex mechanisms underlying molecular biology. However, the high dimensionality and noise inherent in gene expression data pose significant challenges for biomarker discovery and molecular subtype classification in cancer. While deep learning models have shown promise in capturing …
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Dissecting the anti-allergic potential of carnosic acid during IgE and IL-33-mediated mast cell activation
Mast cells are critical immune sentinels and essential regulators of inflammation, most notably recognized for their central role in allergic inflammation. Allergen-induced cross-linkage of FcεRI complexes initiates a biphasic mast cell response, characterized by the immediate degranulation of …
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Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
In the dermis, long-lived resident mast cells are well-situated to respond to mosquito-borne pathogens. Within the Flavivirus genus, dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV) are evolutionarily related mosquito-borne viruses with antigenic similarities. The antigenic …
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Determining the Roles of the Aldehyde Dehydrogenase Enzymes 5 and 6 during Icewine and Table Wine Fermentation in a Commercial Wine Yeast Using CRISPR-Cas9.
… known for Icewine which is fermented from grapes naturally frozen on the vine. Grapes are harvested below –8°C and pressed while frozen, trapping ice crystals inside the berries and releasing juice highly concentrated in sugars and acids. The high sugar juice environment (40°Brix) causes …
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