Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 37 for “"NANOEMULSION"”.
-
Nanoemulsion-like Polymersomes for Nanoreactors
… phase to water produces a very stable kind of "nanoemulsion"�. Nanoemulsion-like polymersomes have great potential as they confine a catalyst within the interiors, thus mitigating the mass transfer limitations of ILs while simultaneously providing a facile route to quantitative catalyst recovery …
-
Nanoemulsion formulations for brain tumour therapy
… project is to investigate the hypothesis that nanoemulsion formulations play an effective role as drug-delivery vehicles for the treatment of glioma. Two commercially available nanoemulsion formulations (Clinoleic TPN 20% and Intralipid TPN 20%) were used in this experiment. They were first …
-
Nanoemulsion-Loaded Hydrogels For Advanced Pharmaceutical Formulations
… we utilize two promising building blocks, nanoemulsions and hydrogels, to design new materials that enable more efficient and effective formulations of oral drug products with high quality and versatile release. First, we present a method to encapsulate functional nanoemulsions in alginate …
-
Elucidating Dual Methylcellulose-and-Oil-Nanoemulsion Thermoresponsive Gelation
… composed of a methylcellulose-stabilized oil nanoemulsion. This system has tunable rheology with two distinct dominant load-bearing components. Oil volume fraction determines which component leads to elasticity in the gel network. At low oil volume fraction, methylcellulose forms a fibrillar …
-
A Transferrin conjugated nanoemulsion system for brain delivery of antiretroviral therapy
… study is to develop a new transferrin conjugated nanoemulsion system (Tf-NE) for antiretroviral medication delivery and evaluate its potential to cross the BBB. Nanoemulsions were prepared based on the solvent evaporation sonication method using lipids and phospholipids. To achieve brain delivery, …
-
Mechanistic study of nanoemulsion absorption and its application for permeation enhancement
<p>Oil in water (o/w) nanoemulsion is a two-phase dispersed system in which the oil can incorporate poorly water soluble drugs to form a liquid dosage form. The enhancement of bioavailability with a use of nanoemulsion has often been reported empirically and speculated to be a result of the …
-
Use of nanoemulsion liquid chromatography (NELC) for the analysis of inhaled drugs. Investigation into the application of oil-in-water nanoemulsion as mobile phase for determination of inhaled drugs in dosage forms and in clinical samples.
… (Phosphate pH 3) were developed and several nanoemulsion mobile phases identified. Nanoemulsion mobile phase that is, prepared with SDS, octane, butanol and a phosphate buffer, failed to separate hydrophilic compounds with a very close chemical structure, such as terbutaline and salbutamol. A …
-
Determination of the Structural and Functional Mechanisms of Perfluorocarbon-based Nanoemulsion Particle Interactions with Model Biomembrane Systems
Perfluorocarbon based nanoemulsion particles: PFC-NEPs) are very small sized: ~ 250 nm in diameter) greasy droplets that are enclosed by emulsifying phospholipid monolayer. PFC-NEPs have been extensively developed for target-specific delivery of therapeutic agents such as imaging agents and drug …
-
Structure, rheology and applications of thermally-gelling nanoemulsions
… effective tool to engineer material properties. Nanoemulsions, liquid-liquid dispersions where the droplet size is on the order of 100 nm, have become an emerging model system for studying aspects of colloidal gel materials. In conventional approaches, the gelation of nanoemulsions relies on the …
-
Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier
… study, we hypothesize that the delivery of lipid nanoemulsion, which is rich in unsaturated fatty acids, will improve insulin signaling at the BBB, and ameliorate insulin resistance caused by cytokines like TNF-α. This, in turn, is expected to decrease VCAM-1 expression and mitigate BBB …
-
Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… as theranostics. A stable 19F MRI visible nanoemulsion platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a theranostic nanoemulsion will reduce the …
-
Macrophage COX-2 As a Target For Imaging And Therapy of Inflammatory Diseases Using Theranostic Nanoemulsions
… as theranostics. A stable 19F MRI visible nanoemulsion platform was developed, incorporating celecoxib for COX-2 inhibition and near-infrared fluorescent dye(s) for fluorescence imaging. We hypothesized that inhibition of COX-2 in macrophages using a theranostic nanoemulsion will reduce the …
-
Development of a Dry Powder Inhaler and Nebulised Nanoparticle-Based Formulations of Curcuminoids for the Potential Treatment of Lung Cancer. Development of Drug Delivery Formulations of Curcuminoids to the Lungs using Air Jet Milling and Sonocrystallisation Techniques for Dry Powder Inhaler Preparations; and Nanoemulsion and Microsuspension for Nebuliser Formulations
… respectively. Nebulised curcuminoids using nanoemulsion and microsuspension formulations were prepared. The physical properties, such as osmolality, pH and the viscosity of the aerosolised nanoemulsion and the microsuspension formulations were determined. The FPF% and MMAD of nebulised …
-
Pilot Study Exploring the Effect of Targeted COX-2 Inhibition in Macrophages Responding to Neuronal Injury; Promoting Enhanced Axonal Regeneration
<p>Celecoxib nanoemulsion (CXB-NE) has been developed as a macrophage targeted analgesics by Dr. Janjic and her team at Duquesne University, (Janjic et al, 2018; Liu et al, 2020; Saleem et al, 2019b; Vasudeva et al, 2014). The CXB-NE nanoemulsion carrying a Nonsteroidal Anti-inflammatory (NSAID) …
-
Formation of nanoemulsions and entrapped microdroplets
… are two broad categories of method to prepare nanoemulsions: high energy and low energy methods. The literature lacks a mechanistic understanding of nanoemulsion formation leading to a trial and error approach. In this thesis, we address this issue by providing a rationale to synthesize …
-
Nanocarriers for drug targeting and improved bioavailability
… morphological studies. An oil in water tretinoin nanoemulsion was also prepared and used as a control. Dermal and transdermal delivery of both tretinoin nanosuspension and nanoemulsion were tested in vitro by using Franz diffusion cells and newborn pig skin. Photodegradation studies were carried …
-
Enhanced physicochemical and functional properties of pea (Pisum sativum) protein by pH-shifting and ultrasonication combined process
… had highest solubility, were used to prepare nanoemulsions (0.25% oil) and nanocomplexes loaded with vitamin D3 (VD3). Storage stability, photooxidation protective ability, and morphological structure of the PPI-stabilized nano-systems were examined. The pH12+U5 treatment increased the …
-
Microfluidic synthesis and properties of bio-inspired colloids
… from crosslinkable silicone oil-in-water nanoemulsions. The nanoemulsion loadings achieved in our composite microgels have, to our knowledge, among the highest ever demonstrated in a hydrogel material. In addition, we perform proof-of-concept assays to show several orthogonal motifs, such …
-
Investigation of the NOx and PM emissions from a diesel engine operating on nanoemulsified fuels
… benefits by running different base diesels and nanoemulsions with varying water content in a single cylinder direct injection Ricardo Hydra engine. The effect of water addition on the base diesel is modeled using a previously verified model of the test engine. The experimental and modeling …
-
Development of dry powder Inhaler and nebulised nanoparticles formulations of chrysin for the potential treatment of asthma. Development of dry powder inhaler of chrysin and nebulised nanoemulsion combination of chrysin and budesonide; Evaluating the anti-inflammatory activity of the combination formulation of chrysin and budesonide for asthma
Chrysin is a flavonoid that can be used as a medication for asthma and chronic obstructive pulmonary disease due to its anti-inflammatory activities. However, no studies have investigated the effectiveness of an inhaled formulation of chrysin on its own or in combination with corticosteroids. …
Page 1 of 2