Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"NAFLD"”.
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THE ROLE OF BETA-KLOTHO PROTEIN IN NAFLD PATHOGENESIS
Non-Alcoholic Fatty Liver Disease (NAFLD) is the most prevalent and progressive liver condition characterized by the accumulation of fat in more than 5% of hepatocytes in the absence of excessive alcohol consumption. Considered a spectrum of liver disorders, NAFLD ranges from simple steatosis, …
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Epithelial cell plasticity in chronic liver disease (MASLD/NAFLD)
It has been proposed that liver regeneration in chronic liver disease, such as metabolic dysfunction-associated steatotic liver disease, previously known as non-alcoholic fatty liver disease, is driven by hepatocyte renewal in the early stages, but when hepatocyte proliferation is impaired due to …
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Development of a Pediatric Model of Nafld in Neonatal Iberian Pigs
… prevalence of non-alcoholic fatty liver disease (NAFLD) in children has increased over the past decades, creating a need for animal models that recapitulate the features of the pediatric disease. Iberian pigs have a leptin-resistant phenotype characterized by hyperleptinemia, hyperphagia, and …
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Hepatoprotective properties of Gentiana SPP: Against non-alcoholic fatty liver disease (NAFLD)
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease characterised by the accumulation of fat in the liver. It is estimated that 33 % of the UK population have NAFLD with 2-5 % progressing to non-alcoholic steatohepatitis (NASH). Due to a lack of an outright therapy for NAFLD, treatment …
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Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD
The pathogenesis of non-alcoholic steatohepatitis (NASH) is thought to occur through interacting mechanisms of cellular stress. Lipids accumulate within hepatocytes, making cells more susceptible to insult and less able to respond to challenges, leading to progression from simple steatosis to …
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CODING E NON-CODING RNA COME BIOMARCATORI DI SEVERITA’ DI NAFLD E DI FIBROSI
… non alcolica (Non-Alcoholic Fatty Liver Disease, NAFLD) è l’epatopatia cronica più comune nei paesi industrializzati con una prevalenza del 20-30% nella popolazione generale. La NAFLD comprende un vasto spettro di patologie epatiche e sebbene sia generalmente considerata una condizione benigna, …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
Non-alcoholic fatty liver disease (NAFLD) is a growing healthcare challenge, affecting ~30% of the global population, however there are currently no specific treatments approved for the disease. A better understanding of pathophysiological mechanisms is required, including the close links between …
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Biopsychosocial profile of non-alcoholic fatty liver disease (NAFLD) associated with liver transplantation and prevention of risk factors
… pacientes con Enfermedad Hepática Crónica CLDQ-NAFLD, Escala Hospitalaria de Ansiedad y Depresión, Inventario de Depresión de Beck, Cuestionario de Afrontamiento COPE-28, Escala de Autoeficacia General, y Escala Multidimensional de Apoyo Social Percibido. Luego se llevaron a cabo diferentes …
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ALTERAZIONE DEL miRNoma INTRACELLULARE ED EXTRACELLULARE ED ANALISI BIOINFORMATICA IN MODELLI IN VITRO DI NAFLD E DI NASH
… non alcolica (Non-alcoholic fatty liver disease NAFLD) interessa circa il 20-30% della popolazione generale e rappresenta la malattia epatica cronica più comune nei paesi industrializzati. La NAFLD presenta un potenziale evolutivo, attraverso la fase infiammatoria denominata NASH (Non-alcoholic …
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Personalised Medicine for Non-Alcoholic Fatty Liver Disease
Non-Alcoholic Fatty Liver Disease (NAFLD) is a chronic and dangerous condition which has grown in prevalence over recent decades due to increasing rates of obesity, affecting roughly a quarter of adults globally. This thesis develops a useable NAFLD definition which can be applied to large …
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Non-Alcoholic Fatty Liver Disease: Investigating the Impact of Bariatric Care and the Role of Immune Function
Non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis (SS) to nonalcoholic steatohepatitis (NASH) and cirrhosis. It is one of the most common causes of chronic liver disease resulting from obesity. 74-98% of morbidly obese individuals have NAFLD at the time of bariatric surgery. …
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The (travel) times they are a changing : a computational framework for the diagnosis of non-alcoholic fatty liver disease (NAFLD)
… to diagnose Non-Alcoholic Fatty Liver Disease (NAFLD). The proposed method is based on two fundamental concepts: 1) the speed of sound in a fatty liver is lower than that in a healthy liver and 2) the quality of an ultrasound image is maximized when the beamforming speed of sound used in image …
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Evaluation of dietary patterns influence on hepatic epigenetic gene modulation and dietary recommendations for the prevention of NAFLD to the general population
Introduction: NAFLD has emerged as a significant public health concern, with its prevalence increasing globally. Emphasizing the complex relationship between dietary patterns and epigenetic modifications such as DNA-methylation or miRNA expression can exert positive impact on preventing and …
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NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of abnormal liver function in countries with western-style high fat, high cholesterol diets. Liver damage associated with NAFLD may lead to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). …
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A systems biology approach to the pathogenesis and progression of Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) refers to a spectrum of diseases ranging from simple steatosis (isolated hepatic fat accumulation) to steatohepatitis (NASH; hepatic fat accumulation with lipotoxicity, hepatic cell damage and inflammation), eventually progressing to fibrosis, cirrhosis and …
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The effects of exercise and omega-3 fatty acid supplementation as treatments for hepatic steatosis
… dietary consumption of n3PUFAs as treatments for NAFLD. Otsuka Long-Evans Tokushima Fatty (OLETF) rats were studied due to their spontaneous development of obesity, insulin resistance, and NAFLD. A novelty of these rats is their intrinsic aptitude for voluntary wheel running despite their obesity. …
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PKC-δ and Insulin Resistance in Non-Alcoholic Fatty Liver Disease: Effect of Vitamin D
ABSTRACT|Nonalcoholic fatty liver disease (NAFLD) due to excess ectopic fat deposit in the liver of nonalcoholic is a broad spectrum of liver diseases encompassing simple liver steatosis to more complicated and morbid steatohepatitis (NASH) that can lead to cirrhosis and even to hepatocellular …
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Lipoprotein lipidomics in obesity-associated metabolic and hepatic disorders
… (CVD). Non-alcoholic fatty liver disease (NAFLD) is one of the most common co-morbidities of MetS. NAFLD ranges from simple steatosis to more aggressive forms, with the potential to evolve to hepatocellular carcinoma and CVD. Lipoprotein dysmetabolism is crucial to both MetS and NAFLD and …
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