Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"NADPH oxidases"”.
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Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy
… Nicotinamide adenine dinucleotide phosphate oxidases (Nox) are proteins responsible for the transport of electrons across biological membranes. It was hypothesized that Nox proteins and their regulatory subunits would be readily expressed in the rat myometrium during pregnancy to help prepare …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… to oxidative stress and increased vascular tone. NADPH oxidases are enzymes whose primary function is to produce ROS, with NOX2 and NOX4 both highly expressed in ECs and upregulated in diabetic and failing hearts. Our hypothesis was that endothelial-specific NOX2 and NOX4 play a key role in …
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Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain
The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response …
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Binding Affinity of Flavins to the Dehydrogenase Domain of SpNOX
<p>NADPH oxidases (NOX’s) are enzymes that catalyze the production of superoxide through single electron transfer. This superoxide production leads to the production of other reactive oxygen species (ROS). ROS affect many metabolic processes throughout the body that can cause several different …
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Investigating the role of NADPH oxidase 4 (NOX4) in differentiation and function of induced pluripotent stem cell–derived endothelial cells
… with recent evidence specifically highlighting NADPH oxidases as a key source. In this thesis, we investigated the role of NADPH oxidase-dependent redox signalling in differentiation of mouse and human iPS-ECs, and provide evidence implicating ROS derived from the NOX4 isoform during the …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
NADPH oxidases are a family of reactive oxygen species generating enzymes which are implicated in cardiovascular pathophysiology. The Nox2-based NADPH oxidase has been reported to be involved in the development of cardiac hypertrophy and fibrosis. However the relevant cellular source(s) involved in …
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Fatty Acid Regulation of NLRP3 Inflammasome Activity
… of NLRP3 specifically requires ROS from NADPH oxidases. PA exposure leads to activation of the MAP kinase JNK in the cytosol of macrophages and interference with JNK signaling blocks PA-induced NLRP3 activation. While SFAs activate the NLRP3 inflammasome, unsaturated fatty acids such as …
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Tumor necrosis factor induced oxidative stress in the central nervous system contributes to sympathoexcitation in heart failure
… studies underscore the importance of central NADPH oxidases in the pathogenesis of hypertension. However, the role of central NADPH oxidase-induced reactive oxygen species (ROS) production in the development of CHF remains limited. In this dissertation, the hypothesis that central PICs induce …
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The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease
… (ROS) production from the mitochondria and NADPH oxidase enzymes following an inflammatory stimulus. We also highlight that the toxic oligomeric amyloid (oAβ) facilitates microglial ROS production and subsequent metabolic changes without triggering an inflammatory response. oAβ facilitated …
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Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
… (DPI), the inhibitor for the O2.--producing NADPH oxidases and silencing of the Nox4 isoform by small interference RNA, we show that the reduction of intracellular level of O2.- in MEFPTEN-/- cells results in a decrease in the phosphorylation level of the otherwise hyperphosphorylated Akt …
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ELUCIDATING THE ROLE OF HET0016 IN AMELIORATING 20-HETE INDUCED OXIDATIVE STRESS AND LIVER INJURY IN B-THALASSEMIA: A NOVEL THERAPEUTIC TARGET
… duration of four weeks. Enzymatic activity of NADPH oxidases was assessed using the NADPH oxidase assay. mRNA expression levels of two isoforms of CYP4A, as well as CYP4A protein levels, were measured in the liver using Real-time Polymerase Chain Reaction (PCR) and western blot, respectively. …
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Electrogenetic pathways in cyanobacteria
… reactive oxygen species (ROS)-generating NADPH oxidases (NOXs), including eukaryotic-like isoforms, suggests polyphyletic evolution of cyanobacterial *nox* genes and a possible eukaryote-to-prokaryote horizontal gene transfer event. These results provide valuable information for the …