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Showing 1 to 20 of 89 for “"NADPH oxidase"”.

  1. NADPH oxidase in PC12 cell differentiation and apoptosis

    Begdache, Lina2016

    … differentiation and apoptosis. In addition, NADPH oxidase has been implicated in the differentiation and apoptosis of this cell line through production of reactive oxygen species (ROS). However, the subunits involved in both processes have not been identified. A series of studies were …

    binghamton Repository record

  2. The Role of NADPH Oxidase in ROS Mediated Differentiation

    Dickson, Benjamin JThe University of Western Ontario2016

    … RA treatment was investigated and members of the NADPH oxidase (NOX) family were identified as candidates as Nox1-4 and Duox2 genes are up-regulated by RA. This study shows Nox1 and Nox4 are up-regulated when Gata6 is overexpressed in F9 cells. Furthermore, the pan-NOX inhibitor VAS2870 and …

    uwo Repository record

  3. Mechanisms of regulation of islet function by nadph oxidase

    Syed, Ismail2012

    … studies have shown activation of phagocyte-like NADPH oxidase [Nox] to be underlying cause for increased ROS generation observed under the above pathological conditions.</p> <p>The overall objective of the present study is to i) determine potential mechanism[s] underlying nutrient-induced …

    wayne-thes Repository record

  4. An investigation of NADPH oxidase in normal and diseased skeletal muscle

    Sullivan-Gunn, MelanieVictoria University2009

    … determine a role for the superoxide generating NADPH oxidase and antioxidant enzyme systems in conditions of skeletal muscle wasting. The results of these studies indicated changes in the gene expression of important components of NADPH oxidase in animal models of age-associated sarcopenia, …

    vu-aus Repository record

  5. THE ROLE OF NADPH OXIDASE IN NEURITE OUTGROWTH AND ZEBRAFISH NEURODEVELOPMENT

    Weaver, Cory J.

    Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are a family of enzymes that produce reactive oxygen species (ROS). The first NOX enzyme was discovered in leukocytes and associated with host defense in the immune system. Subsequent findings of ROS production in non-immune cells led to …

    purdue-thes Repository record

  6. The role of Nox2 containing NADPH oxidase in hypertensive heart disease

    Chaubey, SanjayKing's College London2013

    NADPH oxidases are a family of reactive oxygen species generating enzymes which are implicated in cardiovascular pathophysiology. The Nox2-based NADPH oxidase has been reported to be involved in the development of cardiac hypertrophy and fibrosis. However the relevant cellular source(s) involved in …

    kings Repository record

  7. Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity

    McLaughlin, DeclanQueen's University Belfast2014

    … that ROS generated specifically from Nox2 NADPH oxidase, contributes to key processes underlying cardiac dysfunction associated with chronic DOX treatment. The aim of this study was therefore (1) to characterise the role of Nox2 NADPH oxidase-derived ROS in DOX-induced cardiotoxicity in a 4 …

    qu-belfast Repository record

  8. The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function

    Beske, Phillip Howard

    … role of a key reactive oxygen species generator, NADPH oxidase, in mediating the signaling events leading to alterations in NMDA and AMPA receptor function following ischemia/reperfusion. Therefore, the current series of studies examines the role of reactive oxygen species production from NADPH …

    montana-tech Repository record

  9. The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function

    Beske, Phillip Howard

    … role of a key reactive oxygen species generator, NADPH oxidase, in mediating the signaling events leading to alterations in NMDA and AMPA receptor function following ischemia/reperfusion. Therefore, the current series of studies examines the role of reactive oxygen species production from NADPH …

    montana Repository record

  10. Divergent regulation of zinc metallopeptidases by shear stress in macrovascular endothelial cells via an NADPH oxidase - superoxide pathway

    Guinan, Anthony F.Dublin City University2012

    … inhibitors (Rac1/NSC23766, NADPH oxidase/apocynin) and siRNAs (p47Phox) in shearing experiments to confirm a pivotal role for NADPH oxidase-mediated superoxide production in the LSS mechanotransduction of these reciprocal events. Finally, using a TOP siRNA, an investigation …

    dcu Repository record

  11. Investigating the role of NADPH oxidase 4 (NOX4) in differentiation and function of induced pluripotent stem cell–derived endothelial cells

    Moez, AryaQueen's University Belfast2021

    … with recent evidence specifically highlighting NADPH oxidases as a key source. In this thesis, we investigated the role of NADPH oxidase-dependent redox signalling in differentiation of mouse and human iPS-ECs, and provide evidence implicating ROS derived from the NOX4 isoform during the …

    qu-belfast Repository record

  12. Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways

    Mesquita, Fernando S.University of Illinois at Urbana-Champaign2010

    … of Erk1/2 activation in LSMCs and MSMCs; 4) NADPH oxidase components are expressed in leiomyoma and normal myometrial tissue; 5) PDGF induces translocation of p47phox into lipid rafts in LSMCs; 6) PKC mediates Erk1/2 activation by PDGF in MSMCs and LSMCs; 7) PKC activation alone is sufficient …

    uiuc Repository record

  13. Investigation of Hydrogen Peroxide/Reactive Oxygen Species-Related Signaling on Vasoactive Responses in Myogenic Resistance Arteries

    Kendrick, Dylan JohnCumming School of Medicine2019

    … molecular assays provided the amount of NADPH-oxidase inhibition in the presence of apocynin, ML171 and VAS2870, where pressure myography experiments showed the response of rat cremaster arteries to external hydrogen peroxide, indicating a role for hydrogen peroxide within the …

    calgary Repository record

  14. Solution Structure and Characterization of Lipid Binding of the NOXO1&beta; PX Domain

    Davis, NicoleWake Forest University2010

    The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response …

    wfu Repository record

  15. The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease

    Miller, Rebecca Louise, 1974-University of Missouri--Columbia2007

    … ROS production was attenuate by inhibitors for NADPH oxidase, protein kinase C and extracellular signal-regulated kinases 1/2. Under inflammatory conditions, microglial cells respond to cytokines by induction of inducible nitric oxide synthase which produces nitric oxide (NO). Our results show …

    missouri Repository record

  16. Aktivierung phagozytierender Zellen durch "Advanced Glycation Endproducts" und beta-Amyloid-Implikationen für die Pathogenese der Alzheimer'schen Demenz

    Neumann, ArneUniversität Würzburg

    … Atmungskette, der Radikalquellen Xanthin Oxidase, Lipoxygenase oder Cyclooxygenase. Die Hemmung der NADPH Oxidase reduzierte die Neurotoxizität des konditionierten Mediums auf etwa 30 Prozent. Die NADPH Oxidase ist ein Enzymkomplex, der im Rahmen des "oxidativen bursts" große Mengen …

    wurz-thes Repository record

  17. Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia

    원, 소윤2011

    … induced upregulation of cytosolic components of NADPH oxidase (p67phox), translocation of cytosolic p67phox protein to the membrane, and p67phox expression in microglia in the cortex in vivo, signifying NADPH oxidase activation. The pKr-2-induced oxidation of proteins and loss of cortical neurons …

    ajou Repository record

  18. Cofilin-actin rods: quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway

    Carlson, Adlei B., author, Bamburg, James R., advisor, Di Pietro, Santiago, committee member, Amberg, Gregory C., committee memberColorado State University. Libraries2015

    … the activation of the reactive oxygen producing NADPH oxidase 2 (NOX). If prion-protein density is responsible for whether a rod forms, can we investigate the NOX intensity and duration of activity in relation to where rods form in a neurite? For future study we sought to develop the sensitive …

    colostate Repository record

  19. CAVEOLAE AS SPATIO-TEMPORAL COMPARTMENTS FOR ROS/RNS GENERATION AND NITROXIDATIVE STRESS SIGNALING

    Singh, HarinderTemple University. Libraries2014

    … Our previous studies showed that both NADPH oxidase enzyme complexes and eNOS localize to endothelial caveolae microdomains. Additionally, caveolae internalization has been shown as an activating mechanism for enzyme eNOS. However, roles of caveolae in ROS/RNS generation and downstream …

    temple Repository record

  20. Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models

    허, 수희2012

    … showed activation of microglial NADPH oxidase and astroglial myeloperoxidase (MPO), and subsequent reactive oxygen species (ROS)/reactive nitrogen species (RNS) production and oxidative DNA damage in the MPTP-treated substantia nigra. Additional immunohistochemical staining also …

    ajou Repository record

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