Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"NADPH Oxidase 2"”.
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Cofilin-actin rods: quantification and comparison to tau pathology in a human longitudinal aging study and developing probes to measure localization and activity of NADPH oxidase 2, a component of the prion-dependent rod inducing pathway
… the activation of the reactive oxygen producing NADPH oxidase 2 (NOX). If prion-protein density is responsible for whether a rod forms, can we investigate the NOX intensity and duration of activity in relation to where rods form in a neurite? For future study we sought to develop the sensitive …
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THE ROLE OF CAVEOLAE IN THE FORMATION OF ABDOMINAL AORTIC ANEURYSMS
… were co-infused with Ang-II and BAPN, a lysyl oxidase inhibitor, to induce AAA. We found that mice lacking the main structural protein of caveolae, caveolin-1, did not develop AAA compared to WT animals in spite of hypertensive blood pressures measured by telemetry in both groups. This finding …
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SATB1 binds to multiple sites in the GP91-phox promoter and represses gene expression
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Magnetic Resonance Imaging in the Assessment of Anti Prion Mediated Neurotoxicity In Vivo
… in vivo. As a major source of ROS, I identified NADPH oxidase 2 (NOX2). As in bona fide prion infection, I could detect fodrin cleavage as a marker for calpain activation in homogenates from antiprion injected brain tissue. These findings are indicative that similar pathways are activated in both …
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EXPLOITATION OF ANTIOXIDANT BIOACTIVE COMPOUNDS FROM AGRO-INDUSTRIAL BY-PRODUCTS
… inducible nitric oxide synthase (iNOS), and NADPH oxidase 2 (NOX2), enzymes that are responsible for the improvement of cellular antioxidant defences, the release of nitric oxide (NO), and the production of ROS. The results obtained in the PhD project have shown that the four selected …
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Triggering Nox2 / ROS Signaling During Disuse-Induced Skeletal Muscle Atrophy
… FoxO3a. Upregulation of the Nox2 isoform of NADPH oxidase has been implicated in the disuse-associated increase in ROS production. Evidence indicates that activation of angiotensin II type 1 receptor (AT1R) is an upstream event leading to Nox2 complex formation and activity. In the current …