Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 256 for “"NADPH"”.
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NADPH oxidase in PC12 cell differentiation and apoptosis
… differentiation and apoptosis. In addition, NADPH oxidase has been implicated in the differentiation and apoptosis of this cell line through production of reactive oxygen species (ROS). However, the subunits involved in both processes have not been identified. A series of studies were …
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The Role of NADPH Oxidase in ROS Mediated Differentiation
… RA treatment was investigated and members of the NADPH oxidase (NOX) family were identified as candidates as Nox1-4 and Duox2 genes are up-regulated by RA. This study shows Nox1 and Nox4 are up-regulated when Gata6 is overexpressed in F9 cells. Furthermore, the pan-NOX inhibitor VAS2870 and …
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Mechanisms of regulation of islet function by nadph oxidase
… studies have shown activation of phagocyte-like NADPH oxidase [Nox] to be underlying cause for increased ROS generation observed under the above pathological conditions.</p> <p>The overall objective of the present study is to i) determine potential mechanism[s] underlying nutrient-induced …
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Characterization of NADPH Oxidases in Uterine Smooth Muscle during Pregnancy
During gestation, the uterine smooth muscle, or myometrium, transforms from a quiescent tissue to a contractile muscle required for parturition. Immune system activation is a crucial precursor to labour during which the myometrium is infiltrated by immune cells. Immune and myocyte activation rely …
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Toward Quantitative Understanding of Compartmentalized NADPH Metabolism in Cancer Cells
… nicotinamide adenine dinucleotide phosphate (NADPH) is an essential molecule in living organisms by virtue of its function as electron donor driving reductive biosynthesis and protecting cells against oxidative stress. Over the past decades, extensive research has studied key NADPH …
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Exploring Beta Cell NADPH production using Organelle-targeted Apollo-NADP+ Sensors
… which are important for production of beta cell NADPH to support biomolecule synthesis during cell growth and for the quenching of reactive oxygen species generated during oxidative stress. We hypothesized there exist changes in beta cell NADPH associated with development of beta cell senescence. …
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An investigation of NADPH oxidase in normal and diseased skeletal muscle
… determine a role for the superoxide generating NADPH oxidase and antioxidant enzyme systems in conditions of skeletal muscle wasting. The results of these studies indicated changes in the gene expression of important components of NADPH oxidase in animal models of age-associated sarcopenia, …
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Metabolic Engineering and Transhydrogenase Effects on NADPH Availability in Escherichia coli
… are cofactor-dependent. The reducing equivalent NADPH is required in several enzymatic reactions leading up to the synthesis of high-value compounds like polymers, chiral alcohols, and antibiotics. However, it’s a highly costly compound with limited intracellular availability. This study focuses …
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THE ROLE OF NADPH OXIDASE IN NEURITE OUTGROWTH AND ZEBRAFISH NEURODEVELOPMENT
Nicotinamide adenine dinucleotide phosphate oxidases (NOX) are a family of enzymes that produce reactive oxygen species (ROS). The first NOX enzyme was discovered in leukocytes and associated with host defense in the immune system. Subsequent findings of ROS production in non-immune cells led to …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
NADPH oxidases are a family of reactive oxygen species generating enzymes which are implicated in cardiovascular pathophysiology. The Nox2-based NADPH oxidase has been reported to be involved in the development of cardiac hypertrophy and fibrosis. However the relevant cellular source(s) involved in …
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Developing assays to study and screen engineered Escherichia coli NADPH-dependent sulfite reductase
… the desired variants. The Escherichia coli NADPH-dependent sulfite reductase is a heterododecameric complex that mediates one of the three known six-electron reductions in biological systems, catalyzing the reduction of sulfite to sulfide. Its higher order structure consists of an oxidative …
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Endothelial NADPH oxidases as regulators of coronary microvascular dysfunction in diabetic cardiac remodeling
… to oxidative stress and increased vascular tone. NADPH oxidases are enzymes whose primary function is to produce ROS, with NOX2 and NOX4 both highly expressed in ECs and upregulated in diabetic and failing hearts. Our hypothesis was that endothelial-specific NOX2 and NOX4 play a key role in …
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Investigation into the mechanism of Nox2 NADPH oxidase-dependent signalling in doxorubicin cardiotoxicity
… that ROS generated specifically from Nox2 NADPH oxidase, contributes to key processes underlying cardiac dysfunction associated with chronic DOX treatment. The aim of this study was therefore (1) to characterise the role of Nox2 NADPH oxidase-derived ROS in DOX-induced cardiotoxicity in a 4 …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… role of a key reactive oxygen species generator, NADPH oxidase, in mediating the signaling events leading to alterations in NMDA and AMPA receptor function following ischemia/reperfusion. Therefore, the current series of studies examines the role of reactive oxygen species production from NADPH …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… role of a key reactive oxygen species generator, NADPH oxidase, in mediating the signaling events leading to alterations in NMDA and AMPA receptor function following ischemia/reperfusion. Therefore, the current series of studies examines the role of reactive oxygen species production from NADPH …
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Divergent regulation of zinc metallopeptidases by shear stress in macrovascular endothelial cells via an NADPH oxidase - superoxide pathway
… inhibitors (Rac1/NSC23766, NADPH oxidase/apocynin) and siRNAs (p47Phox) in shearing experiments to confirm a pivotal role for NADPH oxidase-mediated superoxide production in the LSS mechanotransduction of these reciprocal events. Finally, using a TOP siRNA, an investigation …
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Investigating the role of NADPH oxidase 4 (NOX4) in differentiation and function of induced pluripotent stem cell–derived endothelial cells
… with recent evidence specifically highlighting NADPH oxidases as a key source. In this thesis, we investigated the role of NADPH oxidase-dependent redox signalling in differentiation of mouse and human iPS-ECs, and provide evidence implicating ROS derived from the NOX4 isoform during the …
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Characterization of the NADPH oxidase complex in human leiomyoma and normal myometrial smooth muscle cells and its role in PDGF and EGF signaling pathways
… of Erk1/2 activation in LSMCs and MSMCs; 4) NADPH oxidase components are expressed in leiomyoma and normal myometrial tissue; 5) PDGF induces translocation of p47phox into lipid rafts in LSMCs; 6) PKC mediates Erk1/2 activation by PDGF in MSMCs and LSMCs; 7) PKC activation alone is sufficient …
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NADPH-d staining in the supraoptic and paraventricular nuclei increases in late pregnant and lactating rats and is influenced by ovarian steroids and central oxytocin levels
… research has demonstrated that staining for NADPH-diaphorase (NADPH-d) a histochemical marker for nitric oxide synthase is increased in the supraoptic (SON) and paraventricular (PVN) nuclei in late pregnancy. This work was extended to investigate whether increases in staining were evident at …
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Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain
The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response …
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