Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"NAD-dependent"”.
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Biofuel Cell Anode for NAD-Dependent Enzymes
… oxidation steps depend on the diffusive cofactor NAD+/NADH which by itself presents a great challenge. The optimal performance of a biofuel cell requires continuous operation and oxidation of the fuel which can only be achieved if the enzymes' cofactors are constantly regenerated. NADH oxidation …
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NAD+-DEPENDENT SIRT1 REPROGRAMS CD11C+ DENDRITIC CELLS AND CD4+ T CELLS TO CONTROL IMMUNE POLARITY DURING SEPSIS
There is a deficit in the understanding of immune response polarity during sepsis and acute inflammation. Skewing of the polarity can lead to immunometabolic dysfunction, organ failure, and death from sepsis. Sirtuins are known regulators of immunity and have been shown to play a pivotal role in …
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Characterization of Reduced Phosphorus Metabolism in Alcaligenes Faecalis WM2072 and Xanthobacter Flavus WM2814
… from Pseudomonas stutzeri WM88, which encode an NAD:phosphite oxidoreductase (PtxD) and 2-oxoglutarate-dependent hypophosphite dioxygenase (HtxA). HtxA and PtxD were shown to be required for the utilization of phosphite and hypophosphite by A. faecalis. This organism also has the htxBCD genes …
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The study of cell surface components on Porphyromonas gingivalis
… demonstrated that PgAg1 did function as a NAD-dependent glutamate dehydrogenase enzyme. A PgAg1-deficient isogenic mutant of P. gingivalis was generated by homologousre combination between a suicide vector carrying a deletion-disrupted allele of pgagl andP. gingivalis chromosomal DNA. The …
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… understood. Nicotinamide adenine dinucleotide (NAD+) is an essential small molecule co-factor in metabolic redox reactions as well as a substrate for many NAD+-dependent enzymes, such as poly(ADP-ribose) polymerases (PARPs; e.g., PARP-1) or sirtuins (SIRTs; e.g., SIRT-1), which many of them are …
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Engineering a Fungal L-Arabinose Pathway Towards the Co-Utilization of Hemicellulosic Sugars for Production of Xylitol
… yield due to the organism's evolution not dependent on the production of such high levels of desired product. Xylitol is an attractive pentose sugar alcohol that has many applications in the food, pharmaceutical, and high-value based biochemical product industries. It is still, however, …
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Engineering a Fungal L-Arabinose Pathway Towards the Co-Utilization of Hemicellulosic Sugars for Production of Xylitol
… yield due to the organism’s evolution not dependent on the production of such high levels of desired product. Xylitol is an attractive pentose sugar alcohol that has many applications in the food, pharmaceutical, and high-value based biochemical product industries. It is still, however, …
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Molecular studies of longevity-associated genes in yeast and mammalian cells
… regimen that increases the activity of Sir2p, an NAD-dependent protein deacetylase and important regulator of aging in yeast and some metazoans. Caloric restriction activates respiration, reducing cellular NADH levels and relieving the competitive inhibition of Sir2p by this metabolite. SSD1 …
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Effect of aflatoxin B{u2081} on mitochondrial function
… No relief of the inhibition was obtained with menadione. The site of inhibition appears to be between cytochrome b and cytochrome c₁ (or c). The ADP:0 ratio was also depressed by 35% in the presence of 0.48 mM aflatoxin B₁ when NAD-dependent substrates were employed. Mitochondria from protein …
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Nano-structured platinum-based catalysts for the complete oxidation of ethylene glycol and glycerol
… a nano-structured PtRu electrocatalyst with an NAD-dependent alcohol dehydrogenase for improved oxidation of complex molecules. A nano-structured PtRu catalyst was used to oxidize ethylene glycol and glycerol in neutral media. In situ infrared spectroscopy was used to verify complete oxidation …
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Identification of genes from the poxvirus of a parasitoid wasp
… genes. We also report the presence of a putative NAD+-dependent DNA ligase, only the second example of this gene from a virus. DlEPV clearly is a poxvirus. However, it likely needs to be classified into its own genus as it is quite different to other EPVs.</p>
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Enzymology of dicarboxylic acid metabolism in Corynebacterium sp. strain 7E1C
… 7E1C possesses constitutive NAD+-dependent and NADP+-dependent alcohol dehydrogenases active with mono-ol, a, w-diol and (L)-hydroxyfatty acids. Additional NADP+-dependent octanol dehydrogenase activity was detected after growth on alkyl-containing substrates.4.Corynebacterium …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… Here we have identified Sirtuin 6 (SIRT6), an NAD+ dependent deacetylase, as a key epigenetic regulator in the protection against hepatic fibrosis by suppressing the YAP/TAZ activity. SIRT6 has been previously implicated in the regulation of the canonical transforming growth factor β …
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Genetic analysis of longevity in Saccharomyces cerevisiae
… chromatin at the rDNA by catalyzing a novel NAD-dependent histone deacetylation reaction. This rDNA silencing function is likely to promote long life span by inhibiting rDNA recombination and, hence, the formation of ERCs. Sir2p is required for life span extension by caloric restriction (CR), …
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Novel derivatives of nicotinamide adenine dinucleotide (NAD) and their biological evaluation against NAD-consuming enzymes
Nicotinamide adenine dinucleotide (β-NAD+) is a primary metabolite involved in fundamental biological processes. Its molecular structure with characteristic functional groups, such as the quaternary nitrogen of the nicotinamide ring, and the two high-energy pyrophosphate and nicotinamide …
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Analysis of Interrelationships Among NAD+, PARP1, ADP-Ribosylation, and Splicing in Murine Embryonic Stem Cells
… PARP1 functions both as an enzyme, through its NAD+-dependent ADP-ribosyltransferase catalytic activity, and as a structural protein, through its NAD+-independent nucleic acid binding activity. I observed a dramatic induction of PARP1 catalytic activity during the early stages of mESC …
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A Study Of Novel Activities Of Type Iii Sirtuins: Cobb And Pfsir2A
… a class of nicotinamide adenine dinucleotides (NAD)-dependent histone deacetylases (HDACs) found in all three domains of life. Acetylation-deacetylation of histones lysine residues is an accepted paradigm for gene regulation in eukaryotes. In recent years, proteonomic studies revealed that many …
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Mechanistic Enzymology Of Plasmodium Falciparum Sir2, Structural And Biochemical Studies On Nicotinamidases And The Structure And Function Of Enzymes In The Purine Degradative Pathway From Klebsiella Pneumoniae
… parasite Plasmodium falciparum is shown to be an NAD+-dependent deacetylase and an acetyllysinedependent and acetyllysine-independent NAD+ glycohydrolase. In addition, several examples of the Sir2 modulating enzyme, nicotinamidase, are characterized both structurally and biochemically. These works …
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
… of the Nicotinamide adenine dinucleotide (NAD+) dependent deacetylase Sirtuin 1 (SIRT1) in this impairment of mitophagy/autophagy. Crucially we observed strong support for these key findings in human cancer, where PNC1 expression is inversely correlated with markers of hypoxia signalling, …
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Fuels for flight in the fruit beetle,Pachnoda Sinuata, and control of flight metabolism
… of the enzymes alanine aminotransferase and NAD-dependent malic enzyme which are involved in proline metabolism, while the activities of these enzymes were lower in locust flight muscles. The activity of 3-hydroxyacyl-CoA dehydrogenase, an enzyme used in fatty acid oxidation, is low in the …
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