Global ETD Search
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Showing 1 to 5 of 5 for “"NAD-ADP-ribosyltransferase"”.
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Untersuchungen zur Substratspezifität der ADP-Ribosyltransferasen Clostridium botulinum C2-Toxin und Clostridium perfringens Iota-Toxin
… C2-Toxin gehören zur Familie der binären Aktin-ADP-ribosylierenden Toxine. Die Toxine bestehen aus einer Enzymkomponente (ADP-Ribosyltransferase) und einer separaten Bindungs- und Translokationskomponente, die die Zellaufnahme vermittelt. Die enzymatisch aktiven Toxinbestandteile Iota a (Ia) und …
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Struktur-Funktions-Beziehung der ADP-Ribosyltransferase Clostridium botulinum C2-Toxin
Das Aktin ADP-ribosylierende Clostridium botulinum C2-Toxin ist ein binäres Toxin, das aus der Bindungskomponente C2II und der enzymatischen Komponente C2I besteht. C2I ADP-ribosyliert G-Aktin und depolymerisiert so das Aktinzytoskeletts. In der vorliegenden Arbeit wurde die …
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Studies on a novel poly(ADP-ribosyl)ation polymerase PARP-10 and its functional interaction with c-Myc
… is a member of the protein family of poly(ADP-ribose) polymerases (PARPs) that are protein-modifying and nucleotide-polymerizing enzymes able to catalyze the transfer of multiple ADP-ribose units from NAD+ to substrate proteins. Poly(ADP-ribosyl)ation has been reported to regulate many …
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Mechanistic insights into the PARP10-mediated ADP-ribosylation reaction and analysis of PARP10's subcellular localization
ADP-ribosylation controls many cellular processes, including transcription, DNA repair, and bacterial toxicity. ADP-ribosyltransferases and poly-ADP-ribose polymerases (PARPs) catalyze mono- and poly-ADP-ribosylation, respectively, and depend on a highly conserved glutamate residue in the active …