Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"NAD+ metabolism"”.
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Studies of the NAD metabolism of Haemophilus influenzae
… display a unique growth requirement for intact NAD. This organism, the primary cause of bacterial meningitis, is incapable of synthesis of pyridine nucleotides from the usual precursors. An externally directed nucleotide pyrophosphatase was extracted from the organism and purified 700-fold using …
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The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
… extensive intra and intertumoral heterogeneity. NAD+ is a crucial metabolite involved in energy production, redox balance, and DNA-damage repair, and its biosynthesis and consumption are elevated in GBM. This dissertation investigates the upregulation of NAD+ metabolism in GBM and evaluates …
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Biochemical and Cellular Characterization of NMN Adenylyltransferase 2: A Brain Specific Isoform of an Essential NAD Synthesizing Enzyme
… enzymes that catalyze the synthesis of NAD from NMN and ATP. Nmnat1, -2 and -3 are each expressed from a separate gene and are distinguished from one another by their expression, subcellular localization and enzyme kinetics. Nmnat overexpression in neurons slows the rate of axon …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… enzymatic activity regulates calcium flux and NAD metabolism while its receptor functions drive phosphorylation of ERK, c-Cbl, and p85 PI3K. We found that crippling enzymatic activity with inhibitors or a point mutation (CD38 E226Q) did not affect ATRA induction, while a cytosolic truncation …
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A Role for PI31-Mediated Proteasome Regulation in Proteostasis and Neuronal Health
… cycle progression, protein quality control, and metabolism. Using this system, cells maintain homeostasis by quickly and irreversibly altering signaling pathways in response to changing environmental stimuli. Protein degradation by UPS requires two consecutive steps, 1) the covalent attachment of …
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Dissecting NAMPT Signaling Pathways in Beige Adipocyte Development, Impairment and Maintenance
… aging, overnutrition, and thermoneutrality. The NAD(^+) biosynthetic enzyme nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular stress responses and immune–metabolic crosstalk, yet its roles in thermogenic adipocyte development, maintenance, and failure remain incompletely defined. …
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The role of NAD+ compartmentation and dynamics in Arabidopsis thaliana
Nicotinamide adenine dinucleotide (NAD+) is a fundamental coenzyme required to regulate plant central metabolism and redox status homeostasis. Plants produce NAD+ via de novo and salvage pathways. Despite early steps of the two pathways occur in different subcellular compartments, de novo in …