Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"NAD(P)H oxidase"”.
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Genetische Variabilität in der phagozytären NAD(P)H-Oxidase: Funktionelle Charakterisierung und Bedeutung für die Zytostatika-Therapie
… des multimeren Superoxid-produzierenden Enzyms NAD(P)H-Oxidase an der Entstehung einer Doxorubicin-vermittelten Herzinsuffizienz beteiligt. Ausgehend von diesen Hinweisen sollte in dieser Dissertation die genetische Variabilität der phagozytären NAD(P)H-Oxidase in Bezug auf Genexpression, …
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Regulation von oxidativem Stress durch biomechanische Kräfte und fettreiche Ernährung im Herz-Kreislaufsystem
… als Ursache für deren Entstehung diskutiert. NAD(P)H-Oxidasen, von denen 7 Isoformen der katalytischen Nox-Untereinheiten bekannt sind, stellen dabei die Hauptquelle für vaskuläre Superoxidanionen und oxidativen Stress dar. In dieser Arbeit konnte die vorrangige Bedeutung eines intrazellulär …
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… study was designed to investigate the role of NAD(P)H oxidase (NOX), a major superoxide radical producing enzyme, in AT1 and AT2 receptor function on natriuresis/diuresis in Sprague-Dawley (SD), lean Zucker and obese Zucker rats. The results suggested that NAD(P)H oxidase has its independent …
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Major Collateral Vessels Develop from Pre-existing Small Arteries through RAC2/NOX2 Independent Mechanisms
… mice to investigate the hypothesis that Nox2-NAD(P)H oxidase is required for major collateral growth subsequent to femoral arterial occlusion. Previous studies suggest bone marrow cell (BMC)-derived reactive oxygen species (ROS) produced by the Nox2 subunit of NAD(P)H oxidase plays an …
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Endotheliale Superoxidanionen–Bildung
… gab es erste Hinweise, daß eine der leukozytären NAD(P)H - Oxidase ähnlichen Oxidase auch im Endothel existiert und wesentlich zur endothelialen O2 - - Bildung beiträgt. Wenig erforscht waren jedoch die Regulationsmechanismen dieser Oxidase. Ein bisher noch nicht bekannter Stimulus zur Steigerung …
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The Role Of Oxidative Stress In The Pathogenesis Of Epithelial Ovarian Cancer
… from our laboratory has shown that myeloperoxidase (MPO) is expressed in ovarian cancer cell lines and tissues, with minimal or no expression detected in normal ovarian tissues. Myeloperoxidase is an abundant heme protein, which plays a central role in the formation of reactive oxidant and …
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Impaired tissue responsiveness to B-type natriuretic peptide in heart failure: biochemical bases.
… that BNP-based restoration of homeostasis is inadequate. This equivocal clinical benefit of a recombinant BNP in HF raises the possibility of attenuated BNP response. The objective of this thesis is an examination of three aspects of BNP-related cardiovascular pathophysiology. The first issue …
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Oxidant-dependent regulation of L-type calcium channel activity by angiotensin in vascular smooth muscle
… local generation of hydrogen peroxide by NAD(P)H oxidase and mitochondria are shown to synergistically promote PKC-dependent persistent gating of plasma membrane L- type calcium channels in response to angiotensin II. We show that broad inhibition of hydrogen peroxide signaling by catalase …
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Spontaneous tone in deoxycorticosterone acetate-salt hypertensive rats
… an 02.- scavenger, or apocynin, an inhibitor of NADPH-oxidase, attenuated hypertension. Spontaneous tone was abolished by superoxide dismutase (SOD), tempol, or apocynin in endothelium-intact rings but not in endothelium-denuded rings nor in L-NAME treated rings. Catalase, the enzyme that breaks …
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Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
… examined in vivo through the use of apocynin, a NAD(P)H oxidase inhibitor and 1[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole (CDDO) a triterpenoid mimetic of the Nrf2 anti-oxidant DNA binding element. Data obtained confirmed the hypothesis that both acrolein and sulfite induced ROS in …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
… survival and drug refractory. Mitochondria and NAD(P)H oxidase (NOX) are the major sources of BCR-ABL-induced cellular reactive oxygen species (ROS) production. However, it is still unknown how CML cells maintain the altered redox status, while escaping from the persistent oxidative …
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Age-Related Deficits in Electron Transport Chain Complexes in Rat Neurons and 3xTg-AD Mouse Neurons
… in cytochrome C, cardiolipin, cytochrome C oxidase (CCO) function, and glutamate response that render cells less capable of responding to stress. Rescue experiments showed that estrogen is a promising treatment in restoring neuron function with age. After finding key differences in CCO, we …
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Exercise Training Improves Cerebrovascular Oxidative Stress Regulation and Insulin Stimulated Vasodilation in Juvenile and Mature Pigs
… dismutase (SOD) mimetic (TEMPOL; 1e-4 M) and 3) NAD(P)H Oxidase (NOX) inhibition (Apocynin; 1e-4 M). Physiologic maximum and cumulative change in diameter (AUC) for all groups were compared using a two-way ANOVA (independent variables: age and exercise training). Results: Whereas sedentary pigs …
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Oxidative stress in endothelial cells of patients with coronary artery disease
… nicotinamide adenine (phosphate) dinucleotide (NAD(P)H) oxidase contributes to excess O2- production in the endothelium of patients with this cardiovascular disease. Further cellular investigation revealed a significant increase in expression of mitochondrial superoxide dismutase (SOD2) in …
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The effect of single nucleotide polymorphisms of oxidative stress genes and low grade inflammation upon pulse wave contour analysis, a useful non invasive, intermediate vascular phenotype.
… systems are implicated within oxidative stress; NAD(P)H oxidase and endothelial nitric oxide synthase (eNOS). eNOS generates NO while at the same time, and within the same cells, NAD(P)H plays a powerful role in the generation of SO. Evidence is accumulating that polymorphisms of the genes …