Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"NAD(P)H Dehydrogenase (Quinone)"”.
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Controlled metabolic cell labeling and bioorthogonal click chemistry for cancer targeting
… or endogenous triggers (H2O2, tumor hypoxia, NAD(P)H dehydrogenase quinone 1 (NQO1), and histone deacetylase (HDAC)/cathepsin L (CTSL)). Among them, HDAC/CTSL-responsive acetylated azidomannose (DCL-AAM) mediated excellent cancer-specific labeling in vitro and in vivo, which enhanced tumor …
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Broccoli bioactives: impact on enzyme induction, estrogen metabolism and human cancer cell growth
… activity of the phase II detoxification enzyme NAD(P)H dehydrogenase, quinone 1 (NQO1). The present study demonstrated that combinations of purified SF, quercetin and kaempferol increased NQO1 activity in a synergistic manner in murine hepatoma cells. Broccoli is an active accumulator of …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… toxicity. The phase II detoxification enzyme, NAD(P)H:quinone oxidoreductase-1, NQO1, is dramatically overexpressed in many solid tumor types, including pancreatic ductal adenocarcinoma (PDA) and non-small cell lung cancer (NSCLC). The Boothman laboratory has demonstrated that NQO1 bioactivates …
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Characterisation of Nrf2-signalling and the effects of boosting astrocytic Nrf2 in a mouse model of ischaemic stroke
… genes such as Heme oxygenase-1 (hmox1), NAD(P)H dehydrogenase quinone 1 (nqo1), glutamate-cystine antiporter (xCT; gene slc7a11), sulfiredoxin 1 (srxn1). As astrocytes play a central role in the neuroprotective effects of boosting Nrf2, the overarching hypothesis of the present work is …
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Improving the Efficacy and Expanding the Application of NQO1-Bioactivated Therapeutics
NADPH:quinone oxidoreductase-1 (NQO1)-bioactivated drugs, such as ß-lapachone (ß-lap), are powerful therapeutics for tumor-specific therapy. They react with NQO1, which is highly overexpressed in most solid tumors, to cause a futile redox cycle that results in devastating oxidative DNA damage and …