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Showing 1 to 20 of 442 for “"NAD"”.
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Most nad železniční tratí
Diplomová práce je zaměřena na návrh silničního mostu přes železniční trať. Jsou navrženy tři varianty - monolitická konstrukce, most působící jako nosník s náběhem a prefabrikovaný trámový most. Třetí varianta byla zvolena. Pro vytvoření modelu a zjištění vnitřních sil je využit výpočetní program …
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Problémy trestního soudnictví nad mládeží
The issues of juvenile criminal justice The topic of this diploma thesis is the issues of juvenile criminal justice. Under the term juvenile criminal justice we mean special legislation of mixed (substantial as well as procedural) character, which applies to criminal responsibility, sanctioning and …
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Bytové domy Hrušovany nad Jevišovkou
… pro novostavbu bytového domu v Hrušovanech nad Jevišovkou, zpracované na úrovni dokumentace pro provádění stavby (DPS). Objekt je navržen jako samostatně stojící, čtyřpodlažní s plošným podsklepením. Konstrukční systém budovy využívá tradiční technologii zděných stěn z přesných keramických …
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Novel derivatives of nicotinamide adenine dinucleotide (NAD) and their biological evaluation against NAD-consuming enzymes
Nicotinamide adenine dinucleotide (β-NAD+) is a primary metabolite involved in fundamental biological processes. Its molecular structure with characteristic functional groups, such as the quaternary nitrogen of the nicotinamide ring, and the two high-energy pyrophosphate and nicotinamide …
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Obnova nádraží v Ústí nad Orlicí
… bakalářské práce byla obnova nádraží v Ústí nad Orlicí. Náplní byla Dokumentace pro stavební povolení a Dokumentace pro provedení stavby podle architektonické studie, která byla vypracována v předmětu AG34- Ateliér architektonické tvorby v zimním semestru. Stavba se nachází na okraji města …
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Bytový dům v Ledči nad Sázavou
… bytového domu v ulici Havlíčkova ve městě Ledeč nad Sázavou. Jedná se o volně stojící čtyřpodlažní a nepodsklepený objekt. V prvním nadzemním podlaží se nachází garážová stání, sklepní kóje, technická místnost, úklidová místnost, prádelna, kočárkárna a společenská místnost, která může sloužit k …
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Biofuel Cell Anode for NAD-Dependent Enzymes
… oxidation steps depend on the diffusive cofactor NAD+/NADH which by itself presents a great challenge. The optimal performance of a biofuel cell requires continuous operation and oxidation of the fuel which can only be achieved if the enzymes' cofactors are constantly regenerated. NADH oxidation …
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Spectroscopic Model Studies of Nad Intramolecular Interaction
Made available in DSpace on 2014-12-09T17:36:39Z (GMT). No. of bitstreams: 1 7013477.pdf: 3291955 bytes, checksum: a1c62c1f9189ef295f299b984bd4d859 (MD5) Previous issue date: 1969
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Coenzyme engineering of NAD(P)+ dependent dehydrogenases
Coenzyme nicotinamide adenine dinucleotide (NAD, including the oxidized form-- NAD+ and reduced form--NADH) and the phosphorylated form--nicotinamide adenine dinucleotide phosphate (NADP, including NADP+ and NADPH) are two of the most important biological electron carriers. Most NAD(P) dependent …
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Metabolic Regulation of Transcription Through Compartmentalized NAD+ Biosynthesis
… understood. Nicotinamide adenine dinucleotide (NAD+) is an essential small molecule co-factor in metabolic redox reactions as well as a substrate for many NAD+-dependent enzymes, such as poly(ADP-ribose) polymerases (PARPs; e.g., PARP-1) or sirtuins (SIRTs; e.g., SIRT-1), which many of them are …
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Studies of the NAD metabolism of Haemophilus influenzae
… display a unique growth requirement for intact NAD. This organism, the primary cause of bacterial meningitis, is incapable of synthesis of pyridine nucleotides from the usual precursors. An externally directed nucleotide pyrophosphatase was extracted from the organism and purified 700-fold using …
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Bytová politika a dostupnost bydlení v Rychnově nad Kněžnou
… this problem is solved in the case of Rychnov nad Kněžnou. The city has two major problems. Collapsing transport infrastructure and a lack of housing in private or urban property. The problem of shortage of flats is connected with other social problems such as the creation of illegal hostels, …
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Purification and properties of Bungarus fasciatus venom NAD glycohydrolase
The NAD glycohydrolase (NADase) from Bungarus fasciatus venom was purified over 1000-fold to electrophoretic homogeneity through a 3-step procedure which included affinity chromatography on Cibacron Blue agarose. The enzyme exhibited a broad pH profile with the optimum range between 7-8. Studies on …
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The Identification and Targeting of Altered NAD+ Metabolism in Glioblastoma
… extensive intra and intertumoral heterogeneity. NAD+ is a crucial metabolite involved in energy production, redox balance, and DNA-damage repair, and its biosynthesis and consumption are elevated in GBM. This dissertation investigates the upregulation of NAD+ metabolism in GBM and evaluates …
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Single-cell NAD(H) levels predict clonal lymphocyte expansion dynamics
… clonal lymphocyte dynamics. Herein we identify NAD biosynthesis as a biochemical hub for the TCR affinity-dependent metabolome. Through its’ central anabolic role, NAD biosynthesis governs a quiescence exit checkpoint, pacing proliferation. Normalizing cellular NAD(H) likewise normalizes …
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