Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"NACT"”.
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Pathological response of breast cancer to neo-adjuvant chemotherapy at a single tertiary centre with no access to Trastuzumab
Introduction: Neoadjuvant chemotherapy (NACT) has firmly solidified its status as the gold standard in the treatment of breast cancer for eligible patients. While prevailing guidelines advocate for a combined approach involving chemotherapy and Trastuzumab for individuals with HER2-positive breast …
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Functional Magnetic Resonance Imaging of Breast Cancer
… response (pCR) to neoadjuvant chemotherapy (NACT). This thesis compares the diagnostic performance of diffusion-weighted imaging (DWI) models in the breast using a systematic review and meta-analysis. Advanced diffusion models have been proposed that may improve the performance of standard …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… of response to neoadjuvant chemotherapy (NACT). This thesis consists of six chapters: a general introduction to OC (Chapter 1); a thorough review of the literature regarding CTCs and ctDNA in OC (Chapter 2); three results chapters (Chapters 3 - 5); and a final chapter that comprises of a …
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Development of mechanistic energy balance models for grassland
… were developed. The simpler non-interacting (NACT) model assumes the heat and vapour fluxes from the soil surface transfer directly to the atmosphere, with no interaction with the canopy. The interacting (IACT) version exhibits diffusive exchange and hence greater coupling between the canopy …
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MULTI-OMIC LINEAGE TRACING PREDICTS THE MOLECULAR DRIVERS OF CANCER STEM CELLS IN TRIPLENEGATIVE BREAST CANCER EVOLUTION.
… rely primarily on chemo-neoadjuvant therapy (NACT). Their poor prognosis is largely driven by extensive phenotypic heterogeneity, sustained by complex genetic and epigenetic interactions that are difficult to dissect without perturbing the native cellular context in which multiple …
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The scattering of thermal phonons by extended defects in dielectric crystals
… The thermal conductivities of LiF and NaCt containing 500 low-angle grain boundaries per cm were measured in the range 0.08-5 K. The measurements gave little or no evidence for phonon scattering from the·grain boundaries. In light of available models of phonon scattering, this suggests …
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Unravelling the Spatial and Temporal Heterogeneity of High-Grade Serous Ovarian Cancer Using Imaging-Based Biomarkers
… composition under neoadjuvant chemotherapy (NACT) from pre-treatment baseline scans. Throughout the investigations, practical constraints and potential improvements have been identified and discussed.
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PET-MR Imaging of Hypoxia and Vascularity in Breast Cancer
… in patients undergoing neoadjuvant chemotherapy (NACT) and provides projections for future work.
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Targeted next generation sequencing to improve solid tumour diagnosis using tissue-derived and cell-free DNA
… response to neoadjuvant chemotherapy (NACT) in breast cancer patients and radiotherapy in non-small cell lung cancer (NSCLC) patients, using targeted sequencing mutation analysis on ctDNA. In summary, the use of targeted NGS using both tissue and plasma-derived DNA has been evaluated in …
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Molecular transport properties of sodium/dicarboxylate cotransporters
… di- and tricarboxylate transporters, NaDC1 and NaCT, and a sodium-independent pathway, possibly an organic anion transporter. Most of the succinate transport is mediated by sodium-dependent pathways, predominantly NaDC1. In contrast, citrate transport in Caco-2 cells occurs by a combination of …
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Comparison of 18F-Fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (18F-FDG PET/CT) and conventional imaging (CI) for locally advanced breast cancer staging: a prospective study from a tertiary hospital cancer centre in Western Cape
Background: Breast cancer is the second most common cancer in adults and the most frequent cancer diagnosed in women. In South Africa, breast cancer accounts for 38.5% of cancers diagnosed in women. Since the presence, extent and location of distant metastases is one important prognostic factor in …