Global ETD Search
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Showing 1 to 6 of 6 for “"N-myristoylation"”.
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A Phosphoinositide-Specific Phospholipase C of Trypanosoma Cruzi: Unique Characteristics of a Delta-Type Homologue
… revealed some unique features such as an N-myristoylation consensus sequence at its N-terminal end, lack of an apparent PH domain and a highly charged linker region between the catalytic X and Y domains. TcPI-PLC is lipid modified in vivo as demonstrated by metabolic labeling with …
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Lysine Polyphosphate Modification Regulates Enzymatic and Signaling Functions in Eukaryotic and Bacterial Systems
… functional analysis of a selected KPM target, N-myristoylation transferase 2 (NMT2). Using a fluorescence-based enzymatic assay, we observed that KPM of NMT2 reduces the release of myristoyl groups, consistent with partial inhibition of its catalytic activity. These results provide functional …
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Trimming Fat Upon Infection: Proteolytic Demyristoylation as a Novel Bacterial Pathogenic Strategy
… of IpaJ as a research tool to study protein N-myristoylation and the mechanisms of membrane trafficking.
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Assessment of <i>N</i>-myristoyltransferase and the <i>N</i>-myristoylomeas a potential chemotherapeutic target in<i>Trypanosoma cruzi</i>
… of the epimastigote. While both NMT and <i>N</i>-myristoylationwere detected in all lifecycle stages, there were subtle differences in theexpression of several myristoylated proteins. However, at least ~10 myristoylatedproteins were common throughout the lifecycle. In addition, …
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Deciphering host-parasite molecular networks mediating resistance to toxoplasma gondii
… In addition, one of the GIMAPs contained an N-myristoylation motif that is important for protein–protein/lipid interaction and plays an essential role in membrane targeting. Importantly, we found that all those GIMAPs possess an LC3-interacting region (LIR) that is important for recruitment of …
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Chemical Reporters for Investigating Lipidated Proteins at the Host-Pathogen Interface
<p>Lipidation of proteins regulates many cellular processes such as signaling transduction and membrane sorting by modulating protein localization and proteinprotein interactions. As such, defects in protein lipidation can render host cells more susceptible to microbial infection and are also …