Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"N-methyltransferase"”.
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Genetic effect of histamine N-methyltransferase (HNMT) polymorphism on chronic urticaria with aspirin hypersensitivity
… (HDC), and two metabolizing enzymes, histamine N-methyltransferase (HNMT) and diamine oxidase (DAO). Especially, the presence of HNMT genetic polymorphisms might results in reduced histamine metabolism and may influence the susceptibility to develop chronic urticaria with aspirin hypersensitivity. …
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Structural and mechanistic studies of class III lanthipeptide biosynthesis, an α-N methyltransferase, and a sabath yerba mate methyltransferase
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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MOLECULAR DRIVERS OF DISEASE PATHOGENESIS IN NONALCOHOLIC STEATOHEPATITIS
… presents the identification of reduced glycine N-methyltransferase, a key regulator of one-carbon metabolism, in human NASH patients. Using a diet-induced animal model of NASH and targeted proteomics and metabolomics it was found glycine N-methyltransferase reduction in NASH leads to an …
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Investigations into the molecular evolution of plant terpene, alkaloid, and urushiol biosynthetic enzymes
… alkaloid biosynthesis (putrescine N-methyltransferase) or primary metabolism (spermidine synthase) by attempting to interconvert a spermidine synthase to encode putrescine N-methyltransferase activity based upon past patterns of natural selection. In contrast to the HPS/TEAS system, …
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Histamine Metabolism During Asthma Induced By Inhalation Challenge
… assay based upon the specificity of HM-N-methyltransferase harvested from rat brains. DAO was determined with o-dianisidine in plasma buffered at pH 7.4. Thirteen asthmatics were bronchial Responders. The provocative dose of MCH yielding a 20% FEV(,1) fall (PD(,20) -FEV(,1)) ranged from …
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The γ-tocopherol-like family of N-methyltransferases: A taxonomically clustered gene family encoding enzymes responsible for N-methylation of monoterpene indole alkaloids
… reported the identification of a γ-tocopherol C-methyltransferase homologue capable of indole N-methylating 2,3-dihydrotabersonine and Virus Induced Gene Silencing (VIGS) suppression of the messenger has since proven its involvement in vindoline biosynthesis. Recent large scale sequencing …
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Aufklärung der Funktion von zwei rRNA-Methyltransferasen und Untersuchungen zur Eurekanat-Biosynthese in Streptomyces viridochromogenes Tü57
… eigenen Ribosomen durch zwei AdoMet-abhängige Methyltransferasen schützt (AviRa und AviRb), die spezifische Nukleotide der 23S rRNA modifizieren. Verkürzte in-vitro-Transkripte der Domäne V der 23S rRNA dienten als Substrate für Methylierungsversuche mit beiden heterolog exprimierten …
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Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
… depended on the activity of the histone-lysine N-methyltransferase EZH2. The ATP/purinergic signaling was a key regulator of this load induced chromatin condensation, and was mediated by acto-myosin cellular contractility. In follow on studies, we demonstrated that chromatin condensation in MSCs …
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Epigenetic effects of benzo(a)pyrene in Fundulus heteroclitus and Danio rerio
… used Fundulus to study BaP effects on glycine N-methyltransferase (GNMT) expression throughout development. Fundulus embryos were exposed to waterborne BaP at nominally 10 or 100 μg/L and both GNMT mRNA expression and enzyme activity were measured. Quantitative PCR and whole mount in situ …
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Interaction between retinoids and methyl group metabolism
… or drug-treatment interactions. Glycine N-methyltransferase (GNMT) is a key protein that regulates the methyl group supply for S-adenosylmethionine-dependent transmethylation reactions. We have shown that retinoid administration increases GNMT activity and protein abundance, thereby leading …
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Investigation of Protein-Protein Interactions among Nicotine Biosynthetic Enzymes and Characterization of a Nicotine Transporter
… two nicotine biosynthetic enzymes putrescine N-methyltransferase (PMT), N-methylputrescine Oxidase (MPO) and the S-adenosylmethionine (SAM) recycling enzyme S-adenosylhomocysteine hydrolase (SAHH) has been proposed. To further explore this hypothesis, protein-protein interactions among nicotine …
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Genetically-programmed suicide of adrenergic cells in the mouse leads to severe left ventricular dysfunction, impaired weight gain, and symptoms of neurological dysfunction
<p>Phenylethanolamine-N-methyltransferase (Pnmt) catalyzes the conversion of noradrenaline to adrenaline and is the last enzyme in the catecholamine biosynthetic pathway. Pnmt serves as a marker for adrenergic cells, and lineage-tracing experiments have identified the embryonic heart and hindbrain …
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Quantitative Real-Time PCR Analysis of Colchicine Pathway and Rhizome Developmental Genes
… 2 Cytochrome P450, Step 4 Cytochrome P450, and N-methyltransferase) and two candidate rhizome developmental genes (REVOLUTA and sucrose synthase). The genes CYP-30999, CYP-5091, NAT-70209, SuSy-69933 and REV-15982 were expressed in leaf and root tissue, while CYP75A109, CYP75A110, NAT-30717, …
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Structural and biochemical studies on tailoring enzymes involved in ribosomal peptides biosynthesis
… critical for the antibacterial activity. The N-methyltransferase responsible for this modification in the gene cluster is very selective to thiazole/(methyl)oxazole substrates with an N-terminal arginine. By studying its crystal structures in complex with truncated substrate analogs as well as …