Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"N-methylation"”.
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The γ-tocopherol-like family of N-methyltransferases: A taxonomically clustered gene family encoding enzymes responsible for N-methylation of monoterpene indole alkaloids
… step, in this pathway, is an indole N-methylation performed by a recently identified N-methyltransfearse (NMT). For almost twenty years the gene encoding this NMT had eluded discovery; however, in 2010 Liscombe et al. reported the identification of a γ-tocopherol C-methyltransferase …
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Enzymology of Gentamicin Biosynthesis
… last common intermediate of the C complex. 6'-C-Methylation generates two branches, with analogous reactions happening in both. Candidate genes and enzymes for the steps from the first 6'-C-methylated intermediate, G418, to an aminated metabolite JI-20B have already been described, but none for …
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STEREOCHEMICAL STUDIES OF 1,2-DIAMINOCYCLOHEXANE AND SOME OF ITS DERIVATIVES
… analysis after the Eschweiler-Clarke N-methylation was found to give a faulty isomer ratio unless special precautions were taken to insure complete reaction, since the cis isomer was found to undergo unusually slow conversion to its tetramethyl derivative compared to the rate of …
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Endocyclic Nucleophilic Methyl Transfer
… gives an ion pair which then annihilates via N-methylation to give two molecules of the betaine.
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Asymmetrische Synthese ausgehend von allylischen Sulfoximinen: neuartige Gamma-Aminosäuren und cyclische Aminosulfoxonium Ylide
… Homoallylic sulfoximines were activated by N-methylation. Treatment with base induced a five-step one-pot domino reaction in the course of which two new ring systems were established stereoselectively. The proposed structures were confirmed by X-ray structure analysis of a very similar …
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De Novo Design and Stabilization of β-Sheet Peptides for Biomimicry of ORR Enzymes
… Additionally, this work examines how backbone N-methylation, which disrupts hydrogen bonding by installing a methyl group to the peptide backbone at the αN, influences peptide oligomerization. A series of peptides, MC4H, MC4H-MeH, MC4H-MeA, and MC4H-MeAMeH, are synthesized to evaluate these …
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New methods for the asymmetric synthesis of α-alkylated ketones and 1,3-amino alcohols
… of PQS; the C-3 Cl, Br and I analogues. N-Methylation of the iodide was also feasible and the usefulness of this compound showcased in Pd-catalysed cross-coupling reactions, thus allowing access to a diverse set of biologically important molecules.
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Design, Synthesis, and Evaluation of N-Methylated H2R2W4
… Therefore, we hypothesized that <em>N</em>-methylation strategy, specifically at the peptide backbone would modulate their cytotoxicity and stability. A series of <em>N</em>-methylated H<sub>2</sub>R<sub>2</sub>W<sub>4 </sub>peptides were designed and synthesized using Fmoc/tBu solid-phase …
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Aspects of the mechanisms of alkaline hydrolysis of amino acid esters
… changes in solvation and ΔS˚ • The results of N-methylation reinforce the need for ΔH˚ and ΔS˚ values if structural effects on pK_a^T values are to be understood. In going from 4-AB Me·HCI to its N, N-dimethyl analogue, pK_a^T falls. Inductive effects predict pK_a^T should rise as the weak +I …
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Establishment of CRISPR-Cas-based gene deletions in Bacillus methanolicus and metabolic engineering towards the production of N-methylglutamate and putrescine
… and the arginine decarboxylase (ADC) pathway. N-Methylation of amino acids is a crucial post-translational modification that adds a methyl group to the nitrogen atom of an amino acid, significantly altering its chemical properties and biological activity. N-Methylglutamate (NMG) is an …