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Showing 1 to 2 of 2 for “"N-methylated peptides"”.
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Ribosomal Synthesis of N-methylated peptides
… isolated from various organisms often contain N-methylated backbones. Such a modification of backbone of the peptide changes its conformational rigidity. This modification improves the biological properties of the peptide, such as improved target affinity, proteolytic stability or membrane …
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Developing peptide-based inhibitors of amylin aggregation as a novel treatment for type 2 diabetes
… of type 2 diabetes. In this study, overlapping peptides were designed to target the binding region (RLANFLVHSS, residues 11-20) of human amylin and their effects on amylin fibril formation were studied. The first generation of peptides, IO1, IO2, IO3, IO4, IO5, IO6 and IO7, showed less than 50% …