Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"N-methyl-D-aspartate receptors"”.
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Probing the depths of unconsciousness with multifunctional neurotechnology
… I hypothesized that ketamine’s inhibition of N-methyl-D-aspartate receptors (NMDARs) leads to a systemic restructuring of both chemical and electrical neuronal signaling which ultimately disrupts consciousness. Systematically testing this hypothesis required the ability to probe electrochemical …
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Mouse Models of GRIN1-Related Neurodevelopmental Disorder and Initial Investigations of Endocannabinoid Modulating Treatments
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors formed as tetrameric complexes of two GluN1 subunits plus two copies of GluN2 or GluN3 subunits, or a mixture of both. These receptors mediate excitatory neurotransmission and play critical roles in processes underlying …
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Insulin Modulates Synaptic Transmission and AMPA Receptor Trafficking Via Insulin Receptor Signaling Molecule In Region CA1 of the Juvenile and Mature Hippocampuss
… juvenile and mature animals, inhibition of N-methyl-D-aspartate receptors (NMDARs) or phosphatidylinositol 3-kinase (PI3K) did not block insulin-LTD. Interestingly, in mature animals, insulin applied in the presence of a PI3K inhibitor converted transient depression into lasting depression …
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An Account of Chemical and Mechanical Regulation of TRPC6 Channels in Podocytes
… stimulation is mediated by surface-expressed receptors, and the roles of angiotensin II type 1 receptors (AT1R), insulin receptors, and N-methyl-D-aspartate receptors (NMDAR) on TRPC6 activity are studied here. In acutely isolated rat glomeruli, angiotensin causes an upregulation of TRPC6 …
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Identification of novel gating mechanisms underlying pharmacological potentiation of NMDA receptors
Excitatory neurotransmission mediated by N-methyl-D-aspartate receptors (NMDARs) is known to play an important role in synaptic plasticity, learning and memory. Moreover, NMDAR dysfunction may contribute to a variety of neuropsychiatric and neurological disorders including schizophrenia, epilepsy, …
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Novel roles of striatal enriched protein phosphatase (STEP) in neuronal intrinsic properties and homeostatic synaptic plasticity
… is involved in the internalization of the N-methyl-D-aspartate receptors (NMDARs) and the α-amino-hydroxy-5-methyl-4-isoxazolepropinoic acid receptors (AMPARs) via dephosphorylating Tyr1472 of GluN2B subunit in NMDAR and 3 Tyr (Tyr869, Tyr873, and Tyr876) of GluA2 subunit in AMPAR. Despite …
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Distinct functional effects of NMDA receptors in normal and leukaemic megakaryocytes
… and express glutamategated Ca2+-permeable N-methyl-D-aspartate receptors (NMDARs). Their involvement in megakaryocytic maturation has been shown in 2003 but details remain limited. The importance of Ca2+ homeostasis in malignant megakaryocytes has been further highlighted only in 2013 through …
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Involvement of the NMDA Receptor in Moderate Ethanol Preconditioning-Dependent Neuroprotection From Amyloid-Beta in Vitro
… possible "sensor" roles of certain cell surface receptors in MEP-mediated neuroprotection from Aβ in vitro. Specifically, Gαi protein-coupled receptors and/or glutamatergic N-methyl-D-aspartate receptors (NMDAR) have been shown to be involved in other neuroprotective preconditioning mechanisms. …
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Συναπτική δράση παραγώγων νευροδιαβιβαστών και αντιεπιληπτικών φαρμάκων στον εγκέφαλο φυσιολογικών και επιληπτικών πειραματοζώων
… of extracellular Κ⁺, b) the activation of NMDA receptors and c) the application of 10μΜ Adenosine (endogenous substance with antiepileptic properties). Epileptic mice (tg/tg) and phenotypically normal controls (tg/+ or +/+) were used for all the experiments (1 and 2), which employed respectively …