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Showing 1 to 20 of 38 for “"N-methyl-D-aspartate (NMDA)"”.

  1. The Influence of Propofol Administration Time on Oxygen Glucose Deprivation-Reperfusion Injury in Rat mixed Cortical Cultures Focused on N-Methyl-D-Aspartate (NMDA) Receptor

    김, 은진2011

    … cascade mainly by overstimulation of N-methyl-D-aspartate (NMDA) receptors. Propofol have been known to have neuroprotective effects. However, the effect of administration time is not well known with in vitro model. This study was conducted to determine whether the propofol …

    ajou Repository record

  2. Pharmacological and Non-pharmacological Prevention of Fentanyl-Induced Cough : A meta-analysis

    김, 지은2014

    … 95% confidence interval (CI) 0.21 – 0.39], N-methyl-D-aspartate (NMDA) receptor antagonists [OR = 0.09, 95% CI 0.02 – 0.42], propofol [OR = 0.07, 95% CI 0.01 – 0.36], α2 agonists [OR = 0.32, 95% CI 0.21 – 0.48], β2 agonists [OR = 0.10, 95% CI 0.03 – 0.30], fentanyl priming [OR = 0.33, 95% CI …

    ajou Repository record

  3. EFFECTS OF SIGMA-1 RECEPTOR AGONISTS ON COMPULSIVE BEHAVIOR AND NEUROPLASTICITY

    Roesner, Shelby F2030

    … include serotonin neurotransmission and N-methyl-D-aspartate (NMDA) receptors. This study evaluated drugs acting as sigma-1 agonists, NMDA receptor antagonists, and serotonin reuptake inhibitors in preclinical animal behavior models for assessing treatments for obsessive compulsive …

    nmu Repository record

  4. Glutamate regulates neurite outgrowth of descending neurons in culture from larval lamprey

    Ryan, Sarah KathleenUniversity of Missouri--Columbia2005

    … channels may also contribute. Particularly, N-methyl D-aspartate (NMDA) application elicited neurite retraction. Glutamate application in the presence of tetrodotoxin (TTX) inhibited neurite outgrowth. Interestingly, TTX inhibited neurite growth, suggesting the neurons may be spontaneously …

    missouri Repository record

  5. The medial prefrontal cortex and the dorsomedial striatum are necessary for working memory in rats: role of NMDA receptors

    Davies, Don 1985-University of Saskatchewan2016

    … I used rats to elucidate the contrbutions of N-methyl-D-aspartate (NMDA) receptors in medial prefrontal cortex (mPFC) and dorsomedial striatum (dmSTR) using two working memory tasks. The trial unique non-match to location (TUNL) task is a delayed-non-match-to-sample visual working memory task …

    sask Repository record

  6. Disambiguating the Similar: Investigating Pattern Separation in Medial Temporal Lobe Structures Using Rodent Models

    Kent, Brianne A.University of Cambridge2015

    … (BDNF) can improve performance by acting via N-methyl-D-aspartate (NMDA) glutamate receptors in the DG and adult-born hippocampal neurons. Manipulating the level of neurogenesis by inhibiting Wnt signalling or by administering acyl-ghrelin systemically is shown to impair and enhance performance …

    cambridge Repository record

  7. Role of Cholesterol 24-Hydroxylase in Hippocampal Long-Term Potentiation

    Ramirez, Denise Marie O'Donnell, Ramirez, Denise Marie O'DonnellUT Southwestern Medical Center2009

    … 24-hydroxylase have specific defects in N-methyl-D-aspartate (NMDA) receptor function, a subtype of ionotropic glutamate receptor essential for long-term potentiation. The subunit composition of NMDA receptors located in various functional pools is normal in 24-hydroxylase knockout …

    utswmed Repository record

  8. The Structural Mechanism of Allosteric Modulation of The Nmda Receptor: A Balance of Tensions

    Sirrieh, Rita E.2015

    <p>N-methyl-D-aspartate (NMDA) receptors are one of the three main types of ionotropic glutamate receptors in the central nervous system. NMDA receptors mediate the rapid excitatory neurotransmission that underlies learning and memory formation. Conversely, NMDA receptors are implicated in a …

    uthsc Repository record

  9. Stress and Hippocampal Plasticity

    Pham, Kara

    … to be regulated by adrenal steroid hormones, N-methyl-D-aspartate (NMDA) receptor activity, psychosocial stress and learning and memory. Repeated restraint stress is known to induce neuroanatomical changes in the hippocampus, such as dendritic remodeling in CA3 neurons and mossy fiber terminal …

    rockefeller Repository record

  10. Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena

    Kucharz, KrzysztofDepartment of Clinical Sciences, Lund University2010

    … show that ER fission is induced during N-methyl D-aspartate (NMDA) receptor-mediated Ca2+ entry to the cell in murine primary cultures and hippocampal slice cultures. Using different pharmacological approaches, we demonstrate, that ER fission is triggered independently on Ca2+ from ER …

    lund Repository record

  11. A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease

    Hirsch, TamaraKing's College London2012

    … which can be treated with amantadine, an N-methyl-D-aspartate (NMDA) receptor antagonist. NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic plasticity, suggesting a role in dyskinesia. This led to the hypothesis that NO, produced by neuronal nitric …

    kings Repository record

  12. The Cross-Talk Between Neurons and Microglia Through Interleukin-4 After Ischemic Injury

    Ting, Shun-Ming, <p><a href="http://www.orcid.org/0000-0002-9086-4616" target="_blank">http://www.orcid.org/0000-0002-9086-4616</a></p>2019

    … show that mild excitotoxic stress produced by N-methyl-D-aspartate (NMDA) receptor (NMDAR) activation (process that normally occurs in the cerebral ischemia) triggers IL-4 production and release by neurons in the primary neuron culture. We also implicated calcineurin and nuclear factor of …

    uthsc Repository record

  13. A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity

    Chiu, Alexander Simon Che-KeanUNSW, Sydney2013

    The cyanotoxin β-methylamino-L-alanine (BMAA) has long been associated with the elevated incidence of amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC). BMAA has been shown to be produced across the cyanobacterial order and its detection has been reported in a variety of aquatic …

    unsw Repository record

  14. MODELING AND MODULATING MYELOID CELL-MEDIATED NEUROINFLAMMATION FOLLOWING HUMAN IMMUNODEFICIENCY VIRUS-1 INFECTION

    Starr, Alexander2023

    … determined i3 neurons were resistant to N-methyl-D-aspartate (NMDA) receptor-mediated toxicity. Using microelectrode arrays and RNA-seq, we recorded altered spontaneous neuronal activity and co-occurring changes in gene expression that both validated established pathways and identified …

    penn Repository record

  15. On The Future Of Antidepressant Treatments: Targeting Neurotrophic Factors And Plasticity

    White, Stephen W2019

    … that low doses of ketamine, a glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist, can provide depressive symptom relief within hours of administration. What is interesting about these findings is that ketamine works on a completely different biological system than typical …

    mississippi Repository record

  16. The synthesis and pharmacology of novel excitatory amino acid mimetics

    Joseph, M.City of London Polytechnic1984

    … three types: (i) Quisqualate/glutamate, (ii) N-methyl-D-aspartate (NMDA) and (iii) Kainate type. The aim of this project has been to develop specific mimetics which act only at one defined site. In particular, attention has been focused on the two former sub-groups. It has been shown that …

    london-metro Repository record

  17. KETAMINE EXPOSURE DURING ADOLESCENCE INCREASES SENSITIVITY TO REWARD-RELATED STIMULI IN ADULTHOOD

    Riggs, Lace Marie2016

    … Recently, the non-competitive N-Methyl-D-aspartate (NMDA) receptor antagonist, ketamine, has been shown to alleviate symptoms of MDD in individuals that suffer from treatment-resistant depression. However, little is known about the potential long-term consequences of ketamine …

    csusb Repository record

  18. Reactive Oxygen Species (ROS) Triggered Delivery System for the Treatment of Diabetic Retinopathy

    Nayak, RachnaCreighton University2018

    … in DR by blocking the overexcitation of N-Methyl-D-aspartate (NMDA) receptors. Thus, the simultaneous administration of both the drugs would provide a complete neurovascular treatment for DR as the current therapy targets only anti-VEGF activity. Furthermore, this study used conjugation of …

    creighton Repository record

  19. Nucleus accumbens dopamine and investigatory behavior : modulation by the ventral subiculum of the hippocampus through the dopamine cell bodies of the ventral tegmental area

    Legault, Mark A1999

    … injections of the excitatory amino acid analog N-methyl-D-aspartate (NMDA). Such injections increased investigatory behavior and elevated dopamine in both the DA terminal region of the NAS and the DA cell body region of the VTA. The elevations in VTA DA reflect dendritically released DA and imply …

    concordia Repository record

  20. Functional implications of behavioral experience effects upon the rat visual cortex

    Wang, XinboUniversity of Illinois at Urbana-Champaign2011

    … channels (VDCCs) and the other by VDCCs and N-methyl-D-aspartate (NMDA) glutamate receptors. In search for functional implications of behavioral experience effects upon neocortex, field evoked responses in the rat visual cortex were examined following complex environment (EC) and individual …

    uiuc Repository record

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