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Showing 1 to 1 of 1 for “"N-heterocyclization"”.
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Synthesis of Amphibian Alkaloids and Development of Acetaminophen Analogues
… An enantioselective iridium-catalyzed N-heterocyclization reaction with either (R)- or (S)-1-phenylethylamine and 1-(5-methoxypyridin-3-yl)-1, 5-pentanediol was employed to generate the 2-(pyridin-3-yl)-piperidine ring system in 69-72% yield. A cis-2, 5-disubstitued pyrrolidine building …