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Showing 1 to 20 of 28 for “"N-heterocycles"”.
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N-Heterocycles for Materials and Catalysis
Contains fulltext : 151783.pdf (Publisher’s version ) (Open Access)
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Synthesis of N-Heterocycles and Thiocines via Electrophilic Divalent Reactive Intermediates
… active compounds. The synthesis of N-heterocycles is interesting and synthetically challenging which has motivated the work of the Driver group. My research has focused on using aryl amines and azides as the N-atom source to synthesize these complex organic scaffolds that possess …
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Amine Nucleophilic Addition to Nitro-alkene as a New Reaction Mode for the Synthesis of N-heterocycles
… as a New Reaction Mode for the Synthesis of N-heterocycles: An efficient stereoselective synthesis of polycyclic lactams has been developed using Michael addition of conjugated amino-esters to nitro-alkenes. Using acyclic and cyclic aminoesters, this method provided a promising approach to the …
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SYNTHESIS OF N-HETEROCYCLES VIA PALLADIUM-CATALYZED REDUCTIVE CYCLIZATION REACTIONS OF NITROARENES AND NITROALKENES USING FORMIC ACID DERIVATIVES AS CO SURROGATES
… cyclization reaction of nitroarenes to produce N-heterocycles has been investigated for more than four decades using CO as a cheap reductant, but it is still a fascinating area for research and advancements. On the other hand, using toxic CO gas is accompanied by many disadvantages. Thus, the …
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Formation of Pyrroloindolines and Alkylation of N-heterocycles With Trichloroacetimidates and Synthesis of Quinoline Based Small Molecule Inhibitors of Ghrelin O-acyltransferase (goat)
<p>Pyrroloindolines and related systems are present in a large number of complex natural products. These core structures have generated considerable synthetic interest, as many of the compounds possess challenging, elaborate structures and interesting biological properties. Recently we have focused …
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Nickel-catalyzed asymmetric cross-couplings of secondary alkyl electrophiles and photoinduced, copper-catalyzed C-N couplings
… copper-catalyzed C-N couplings between N-heterocycles and aryl halides. In particular, a variety of N-heterocycles, such as indoles, benzimidazoles, imidazoles, and carbazoles, undergo Ullmann couplings under mild conditions (room temperature) with an inexpensive catalyst (Cul, without an …
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Iridium complexes as highly active catalysts for hydrogen isotope exchange and hydrogen borrowing processes
… been employed in the successful deuteration of N-heterocycles, which represent an important and relatively underexplored class of labelling substrates. The labelling of a large range of indole, pyrrole, and quinoline derivatives is reported, in which the regioselectivity can be controlled through …
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Nickel-catalyzed cross-couplings of unactivated secondary and tertiary alkyl halides and photoinduced copper-mediated asymmetric C-N cross-couplings
… between racemic secondary alkyl halides and N-heterocycles. Preliminary yields and enantioselectivities for a reaction between secondary benzylic halides and carbazoles, with the use of a monodentate chiral phosphine ligand, are presented. The methodology is then extended to secondary …
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A Diversity-Oriented Synthesis Approach to Functionalized Azaheterocycles using Cyclic Alpha-Halo Eneformamides
… synthesis approach to highly functionalized N-heterocycles through the intermediacy of α-halo enamines/enamides. The synthetic utility of the method is exemplified through the construction of quaternary cyclic propargylic and homoallylic amines, polycyclic lactams, as well as chiral dihydro …
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Synthesis, Vinylation and Rearrangement of NH-Isoxazolines and Copper Catalyzed 6 Pi Electrocyclization
… [3,3] sigmatropic rearrangements to access new N-heterocycles in diastereoselective fashion. The work described in Chapter 1 features a new method for accessing enaminones utilizing a cascade approach that features an N–vinylisoxazoline intermediate that undergoes [3,3] sigmatropic rearrangement …
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Bildung und Nutzung multinuklearer Titanocenkomplexe mit N-heterocyclischen Brückenliganden
… sources and higher anellated aromatic N-heterocycles have been investigated and the properties of resulting products were described from different points of view. Quinoxalines and quinolines have been shown to undergo dehydrogenative C-C coupling reactions to produce titanocene complexes …
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Mechanochemistry: Redefining the Paradigm of Organic Chemistry
… as aldehyde surrogates for the synthesis of N-heterocycles and reductive aminations under mechanochemical and microwave systems. Additionally, C‒C bond synthesis reactions using mechanochemically treated wool encompassed sustainability with practicality. Moreover, mechanochemical catalysis for …
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Direct ⍺-C–H Functionalisation of Cyclic Alkylamines
Saturated N-alkyl heterocycles are among the most important structural motifs in natural products, small-molecule biological probes and pharmaceutical agents. Substituted derivatives of these cyclic tertiary alkylamine scaffolds often exhibit markedly different physicochemical and biological …
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Development of Earth Abundant Metal-Catalyzed Reactions to Construct Heterocycles
… afforded six-or seven-membered N-heterocycles. The scope of the reaction is broad and tolerates a range of electron-releasing or electron withdrawing substituents on the nitroarene, and the ortho-substituent can be modified to construct benzoxazines, dihydro benzothiazines, …
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Hemiaminals : a new chemotype for organocatalysis
… α-amination of N-protected hemiaminals from N-heterocycles are reported, in which it was found that the reaction only worked with the carbonyl group exo to the ring. In the case of the hemiaminal derived from N-Boc or N-CBz 2-pyrrolidinone an amination with proline catalyst in acetonitrile over …
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The selective palladium-catalysed decarboxylative coupling of nucleophiles in the presence of propargylic electrophiles
… linker. Despite the weakly acidic nature of N-heterocycles, the reaction proceeds with good efficiency, complete regio- and chemoselectivity and broad substrate scope. Mechanistic studies have also been carried out to help deduce the mechanism of the reaction. The third part of this thesis …
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Interaction of phthalazines with molybdenum hydroxylases. Phthalazine and its 1-substituted derivatives as substrates, inhibitors and inducers of aldehyde oxidase and xanthine oxidase, both in vitro and in vivo.
… and two other hydrazine substituted N-heterocycles, endralazine and 1-hydrazinoisoquinoline have been shown to exert a potent progressive inhibition of aldehyde oxidase in vitro, effective only in the presence of substrate, but are inactive towards xanthine oxidase. In addition, …
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Chemical Sensing of N-Nitrosodimethylamine and Methane
… the synthesis of five phosphines bearing N-heterocycles, followed by coordination with Cu(I) to give luminescent complexes. Emission spectra spanned the visible range, demonstrating the tuneability of these compounds. The complexes’ interactions with N-nitrosamines were also examined through …
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Borenium Cations as Catalysts for the Reduction of Organic Molecules and Mechanistic Investigations into their Mode of Operation
… a wide array of substrates including imines, N-heterocycles, nitriles, and ketones using pinacol borane as the source of hydride. Another borenium ion, synthesized from trityl tetrakis-pentafluorophenyl borate, DABCO, and HBpin did not contain a nucleophilic borohydride counterion and it was …
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Homogeneous and heterogeneous rhenium catalysts for sustainable transformations of polyols, alcohols, and amines
… catalysts, Re NPs catalyze hydrogenation of N-heterocycles. When combined with its dehydrogenation activity, Re NPs supported on carbon (Re/C) acts as a catalyst for reversible hydrogenation/dehydrogenation that has applications in hydrogen storage. This reaction was demonstrated with various …
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