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Showing 1 to 8 of 8 for “"N-heterocycle"”.
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The Study of Au(III) Compounds and their Interaction with Zinc Finger Proteins
… expanded this system to Au(III)-(nucleobase/N-heterocycle) compounds. Novel Au(III)(dien)(N-heterocycle) compounds, including the first Au(III)N3(N-purine) examples, were synthesized. As previously reported for [AuCl(dien)]Cl2, these compounds exhibit pH dependency of the 1H NMR chemical shifts …
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Asymmetric synthesis of quaternary hydantoins and spirocyclic pseudoindoxyls via aza-Heck cyclizations
… drugs in the market contain at least one N-heterocycle, making them one of the most important scaffolds in drug discovery and medicinal chemistry. Hydantoins and pseudoindoxyls in particular, have been immensely studied for their various biological activities, and numerous attempts have been …
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HARNESSING NATURE’S MACHINERY: CHARACTERIZATION OF BACTERIAL BIOSYNTHETIC ENZYMES FOR CHALLENGES IN ORGANIC SYNTHESIS
… of our novel method for biocatalytic N-heterocycle formation. We also include a discussion of our attempts towards enzymatic cofactor generation and recycling to improve the activity of our cryptic sulfotransferases. In Chapter 4, we report novel activity of DszA, a C–S bond cleavage …
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Interactions of platinum compounds with heterocyclic bases.
… of the type cis-PtCl2L2, where L is a N-heterocycle, have been successfully prepared and characterized. The kinetics of the reaction between K2PtCl4 and the N-heterocyclic bases in aqueous solution have beeD studied. This was best achieved by pre-aquating the PtCl4(2-) and measuring the …
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Hydrothermal Liquefaction of Municipal Sludge: Feedstock Composition, Inorganic Interactions, and Co-Liquefaction as a Dewatering Alternative
… in the biochar, whereas Na2CO3 promoted N-heterocycle formation in the biocrude and provided no enhancement in phosphorus recovery. The third study demonstrated that direct blending of dilute WAS with dry pistachio shells reaches the 20 wt.% solids HTL target without mechanical dewatering. …
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Development of Deactivation-Resistant Catalysts for Pd-Catalyzed C–N Cross-Coupling Reactions
… (1) unhindered, (2) five-membered-ring N-heterocycle-containing, and (3) α-tertiary primary amines, each of which previously required a different catalyst to achieve optimal results. Chapter 3: Pd-Catalyzed Amination of Base-Sensitive Five-Membered Heteroaryl Halides with Aliphatic Amines …
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Platinum Complexes and Zinc Finger Proteins: From Target Recognition to Fixation
<p>Bioinorganic chemistry strives to understand the roles of metals in biological systems, whether in the form of naturally occurring or addition of non-essential metals to natural systems. Metal ions play vital roles in many cellular functions such as gene expression/regulation and DNA …
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ESIMS targeted synthesis of novel {Pt2S2} derivatives
… to contain a novel 6-membered Pt-S-Pt-S-C-N heterocycle. 38 was characterised using NMR spectroscopy (1H, 13C, 31P{1H}, and 195Pt{1H}). 39 was characterised using 31P{1H}-NMR spectroscopy. 2 was reacted with selenourea resulting in the detection by ESIMS of the mixed- bridged …