Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"N-ethylmaleimide sensitive factor"”.
-
N-ethylmaleimide sensitive factor (NSF) is a regulator of plasma membrane rupture and necrotic cell death
… membrane rupture andnecrosis. We targeted N-ethylmaleimide sensitive factor (NSF) due to its requirement in SNARE recycling, lack of gene homologs, and redox sensitivity. Deletion of Nsf protected against membrane rupture induced by various necrotic stimuli, yet did not influence apoptosis, …
-
Alcohol alters the expression of Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (SNAREs) and spontaneous γ-Aminobutyric Acid (GABA) release...
… within the central nervous system are highly sensitive and responsive to ethanol. Although the regulation of postsynaptic receptors by alcohol is well studied, the mechanisms underlying the presynaptic effects of alcohol to alter neurotransmitter release remain relatively unexplored. This …
-
An evolutionarily conserved regulatory mechanism for endosomal membrane trafficking
… facilitated by the formation of SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complexes; a process that is regulated by Sec1p/Munc18 (SM) proteins. Membrane fusion has been conserved through evolution and hence a lot or our knowledge about the molecular mechanism …
-
Protein-Protein Interactions That Regulate Neurotransmitter Release From Retinal Ribbon Synapses
… do not contain the t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor) syntaxin 1A that is found in conventional synapses of the nervous system. In contrast, ribbon synapses of the mammalian retina contain the related isoform, syntaxin 3B. Given that SNARE …
-
Single-molecule fluorescence resonance energy transfer study of SNARE-mediated membrane fusion
… some form of fusion. Proteins called soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) play a central role in fusion processes which is also regulated by many accessory proteins, such as synaptotagmin, complexin and Munc18. By a new lipid mixing method at the …
-
Cryo-electron Microscopy of Reconstituted Membrane Fusion Systems
Soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins are responsible for driving the fusion of biological membranes and are present across many different cell trafficiking systems. Synaptic SNARE proteins allow the release of neurotransmitters across synaptic …
-
The role of SNAREs in chlamydial infection: Syntaxin 4 and SNAP-23 disrupt lipid droplets homeostasis
… hospedeira como as proteínas SNARE (Soluble N-ethylmaleimide-sensitive Factor Attachment Protein Receptor). Aqui usámos um modelo de infeção in vitro com Chlamydia trachomatis LGV L2 para estudar a função das SNAREs na aquisição de nutrientes. Os nossos resultados mostram que a SNAP-23 …
-
Regulation of SNARE-Mediated Synaptic Vesicle Release by Synaptotagmins and Complexins
… Ca2+ channels. The SNARE (Soluble N-ethylmaleimide-sensitive-factor Attachment Protein Receptors) complex is the core component of the fusion machinery in the presynaptic terminal, as it forms a physical bridge between the vesicular membrane and the presynaptic target membrane that …
-
Unraveling the Molecular Mechanisms of Munc18 and Munc13 in Mast Cell Exocytosis
… exocytosis is known to be mediated by Soluble N-ethylmaleimide sensitive factor Attachment protein REceptor (SNARE) complex where intertwined helix bundles provide energy to fuse lipid membranes. Furthermore, this process is regulated by indispensable proteins such as Munc18 and Munc13 through …
-
Unraveling the Functions of Synaptotagmin and Munc13 in Neurotransmitter Release
… machinery includes three SNAREs (soluble N-ethylmaleimide sensitive factor adaptor protein receptor) and Munc18-1 as core components. Munc13, synaptotagmin and complexin underlie the exquisitely tight regulation of synaptic exocytosis. The SNAREs form the SNARE complex that brings synaptic …
-
The Functional Organization of Synaptic Vesicle Pools In A Retinal Bipolar Neuron
… these synapses is the role of SNARE (Soluble N-ethylmaleimide sensitive factor Attachment Protein Receptor) proteins. Vesicles at conventional neurons undergo SNARE complex-mediated fusion. However a recent study has suggested that ribbon synapses involved in hearing can operate independently of …
-
Structural and Functional Studies of Munc18 and SNARE Proteins
… from the Sec1/Munc18 (SM) and SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors) families. SNAREs function by forming a four-helix bundle called SNARE complex; assembly of the SNARE complex brings two membranes together and is key for membrane fusion. The function of …
-
Vitamin E und der vesikuläre Transport : Untersuchungen zu den genregulatorischen Funktionen von Vitamin E mittels Microarray- und real time PCR-Analysen in der Maus und funktionellen in vitro Assays in RBL-2H3 Zellen
… α-Tocoperol und die Identifizierung α-Tocopherol-sensitiver Gene in vivo. Zu diesem Zweck wurden Mäuse mit verschiedenen Mengen α-Tocopherol gefüttert. Die Analyse der hepatischen Genexpression mit Hilfe von DNA-Microarrays identifizierte 387 α-Tocopherol-sensitive Gene. Funktionelle …
-
Molecular mechanisms of snare assembly and expulsion of intravesicular contents in cell secretion
… membrane, have been elucidated. Three soluble N-ethylmaleimide-sensitive factor (NSF)-attachment protein receptors called SNAREs, have been implicated in membrane fusion in cells. For example in neurons, target membrane proteins SNAP-25 and syntaxin (t-SNARE) present at the porosome base, and a …
-
SNARE-mediated exocytosis of MUC2 from intestinal goblet cells
… out by specialized members of the Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein SNARE family that facilitates vesicle-membrane fusion events. R-SNAREs, predominantly vesicle-associated membrane proteins (VAMP) present on vesicles bind to Qabc-SNARE complexes present on the …
-
INVESTIGATING THE ROLE OF SNAP29 AND THE AUTOPHAGY PATHWAY IN DROSOPHILA MELANOGASTER MODELS OF C9ORF72 - LINKED ALS/FTD.
… pathogenic mechanisms, and genetic risk factors. Notably, a hexanucleotide repeat expansion of G4C2 in the non-coding region of the C9orf72 gene is frequently observed in patients with ALS and FTD. This repeat expansion is known to contribute to disease through a dual mechanism: loss of …
-
Regulation of SNARE function during sperm capacitation to promote the acrosome reaction
… to the World Health Organization, the male factor alone accounts for over one third of total infertility. There are various causes of male infertility but defective acrosomal exocytosis is perhaps one of the biggest contributors towards male infertility. Unfortunately there is little …
-
Mutational analysis of the Vam3 transmembrane domain and its effects on vacuole fusion in Saccharomyces cerevisiae
Vam3 is a SNARE protein essential in yeast vacuole homotypic fusion. The specific role of the Vam3 trans-membrane domain (TMD) during vacuole fusion remains unclear. Previous work had shown that replacing Vam3 TMD with a prenyl lipid anchor (CCIIM) results in attenuated fusion and accumulation of …
-
Improvement of soybean breeding via high throughput phenotyping and disease resistance
… allele type to investigate the effect of these factors and their interaction on SCN resistance. F2 plants from each cross were evaluated for the segregation of Rhg1 and Rhg4 alleles and for SCN reproduction after infesting plants with HG type 2.5.7 and HG type 7 populations. Within repeat types, …
-
Investigating the regulation of the PCTAIRE-1 protein kinase : a new target of AMP-activated protein kinase and beyond?
PCTK1 is a Cdc2-related protein kinase that is poorly characterised. Several studies have investigated its role and regulation, and have provided some insight into its upstream regulation by PKA/CDK5 phosphorylation. Proposed physiological functions include vesicle trafficking and neurite …