Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"N-demethylation"”.
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Impact of CYP2C8 single nucleotide polymorphisms on in-vitro metabolism of imatinib to N-desmethyl imatinib
… examine the impact of CYP2C8*3 and CYP2C8*4 on N-demethylation of imatinib in HLMs genotyped for CYP2C8*1/*1 (n=5), CYP2C8*1/*3 (n=4), CYP2C8*1/*4 (n=2), in CYP2C8*3/*3 pooled HLM, and in expressed CYP2C8 and CYP3A4 enzymes. Effects of CYP-selective chemical and antibody inhibitors on …
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Enantiodivergent chemoenzymatic synthesis of codeine
… two novel ·transition metal catalyzed N-demethylation procedures for opioids, and the development of a catalytic protocol for N-demethylation and Nacylation of morphine and tropane alkaloids are presented. In addition, reactions of a menthol-based version of the Burgess reagent with …
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Methadone metabolism in placentas from preterm pregnancies
… the enzyme system responsible for the N-demethylation of methadone in human preterm placentas. The metabolism of methadone revealed typical Michaelis-Menten saturation kinetics. Methadone was N-demethylated to EDDP, only, by human placental aromatase. This was confirmed through the use of …
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The fluroxene mediated degradation of cytochromes P-450
… the hydroxylation of benzpyrene, the N-demethylation of ethyl-morphine and the binding of ethyl isocyanide, it is established that only cytochrome P-450 is degraded by fluroxene in vivo following phenobarbital induction of animals, and both cytochrome P-450 and cytochrome P-448 following …
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Quantum chemical modeling of redox reactivity, degradation pathways and persistence for aqueous phase contaminants
… is predicted to proceed through sequential N-demethylation. Experimental validation confirms the predicted pathways of HMPA oxidation by permanganate to phosphoramide via the formation of less methylated as well as singly and multiply oxygenated reaction intermediates. Pathways predicted to be …
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Studies on the induction of the hepatic microsomal mixed function oxidase system
… and V<sub>max</sub> for ethylmorphine N-demethylation is dependent on the substrate concentration range used to determine them. The oxidase system appears to have two different activities, one involving low substrate concentrations; the other, high substrate concentrations. During …
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Studien zum Metabolismus von Pestiziden und Xenobiotika durch humane Cytochrom-P450-Monooxygenasen in transgenen Tabakzellkulturen
… The three reactions are the desulfuration, N-demethylation and O-demethylation. Nevertheless, there was no evidence that dimethoat was a suitable substrate for the two P450 isoenzymes. Only a slight increase in the conversion rate of dimethoate could be found by the CYP1A2 enzyme which was …
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Biotransformation von N-Alkyl- und N,N-Dialkylarylaminen durch Bacillus megaterium
In der vorliegenden Arbeit wurden Studien zur bakteriellen Biotransformation von N Alkyl- sowie N,N Dialkylarylaminen mit dem Ziel der arylischen Hydroxy-lierung und N-Dealkylierung durchgeführt. Bodenproben wurden einem Screening-Verfahren unterworfen, um selektiv nach Mikroorganismen zu suchen, …