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Showing 1 to 9 of 9 for “"N-carboxyanhydride"”.
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Design and synthesis of protein mimetics via living polymerization of β-sheets-forming n-carboxyanhydride
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Determination of L- and D-methionine and L- and D-valine in soy isolate and soy flour samples
… isolate samples were coupled with L-leucine-N-carboxyanhydride. If both D- and L-forms were present this would produce diastereomeric dipeptide derivatives. The derivatives were separated by ion-exchange chromatography using a TSM Amino Acid Analyzer. Comparison of the sample methionine and …
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I. Macromolecular and architectural effects on the polymerization of α-helices & II. Functional ROMP curing polyester thermosets
… but also tertiary structure. Utilizing N-carboxyanhydride monomers that polymerize to form polypeptides, the folding of the polymers into alpha-helices was shown to drastically increase the rate of propagation. Furthermore, when the alpha-helices were organized in a close, parallel array …
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Step-growth hydrogels crosslinked through grafted polypeptides enable nano- to macroscale synthetic extracellular matrix design
… extracellular matrix. A specific grafted N-carboxyanhydride polypeptide, poly(y-propargyl-L-glutamate) (PPLG), forms the foundation of this thesis. PPLG is an especially useful polymer for exploring hydrogel crosslinking through grafted polypeptides because it 1) can be grafted with nearly …
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Synthesis and Surface Characterization of Silica-Polypeptide Composite Particles
… used as initiators for the polymerization of N-carboxyanhydrides (NCAs) yielding silica-polypeptide composite particles. The polypeptide content of silica-PBLG (silica-poly(ƒ×-benzyl-L-glutamate)) was controlled when the synthesis was performed by sequential addition of N-carboxyanhydride …
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Synthesis and performance of novel supramolecular tools for single-particle cryogenic electron microscopy and drug and gene delivery
… for the synthesis of cyclic amino-acid-N-carboxyanhydride monomers for synthesis of polypeptides utilizing tetrahydrofuran (THF) as solvent was developed and used to synthesize a small library of some novel and previously reported NCA monomers in superior yield and purity.</p>
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Flow Chemistry Guided by Computer-Aided Synthesis Planning
… general amide coupling approach facilitated by N‐carboxyanhydride activation that was further characterized by reaction kinetics analysis in batch. The three‐step continuous process was demonstrated by synthesizing 8 different ACE inhibitors in up to 88% yield with throughput values in the range …
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Lineare und verzweigte Blockcopolymere aus Polypeptiden und synthetischen Polymeren
… ringöffnender Polymerisation von Aminosäuren-N-Carboxyanhydriden (NCA) synthetisiert. Die Untersuchung der Polypeptid-Blockcopolymere hinsichtlich ihres Aggregationsverhaltens in fester Phase sowie in verdünnter wässriger Lösung erfolgte mittels Streumethoden (SAXS, WAXS, DLS) sowie abbildender …
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Doppelthydrophile Blockcopolymere als Mineralisationstemplate
… wurden durch ringöffnende Polymerisation von N-carboxyanhydriden (NCA′s) und a-methoxy-ω-amino[poly(ethylene glycol)] PEG-NH2 als Initiator hergestellt. Die hergestellten Blockcopolymere wurden als effektive Wachstumsmodifikatoren für die Kristallisation von Calciumcarbonat und Bariumsulfat …