Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"N-cadherin"”.
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Engineering biomaterial surfaces with N-cadherin
N-cadherin is a key protein that is responsible for cellular adhesion to neighboring cells in mesenchymal tissues. It plays a significant role in neural development, regeneration, and pathological processes. Recently, efforts were increasingly made to better understand biological function of …
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Engineered N-cadherin substrates for stem cell differentiation
… which implies that there is an important role of cadherin-modulated cell-cell adhesion in regulating stem cell differentiation levels. As a result, the goal for this research is to develop a hydrogel platform which integrates the effects of N-cadherin and matrix stiffness to modulate cell …
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Alternative Splicing Expands Spatiotemporal Expression Complexity of Arthropod N -Cadherin
… silico approaches to show that the arthropod N-Cadherin gene has maintained exactly the same genomic organization, a common promoter and three sets of mutually exclusive alternatively-spliced exons (MEs), for over 400 million years. Furthermore, in vivo studies demonstrated that isoforms derived …
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The role of N-cadherin and S1P/S1P1 in pancreas development
… essential for the development of the pancreas. N-cadherin deficient-embryos suffer from dorsal pancreas agenesis due to apoptosis of the mesenchyme surrounding the pancreatic epithelium. N-cadherin-deficient embryos expressing N-cadherin or E-cadherin ectopically in the heart rescue dorsal …
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Investigation of minimum fragment requirement for mimicking n-cadherin mediated adhesion
Cadherins are transmembrane glycoproteins that are involved in maintaining integrity of cell junctions, morphogenesis, cell sorting and many more important biological processes. In my thesis, I have focused on studying the binding affinity of a class of cadherin superfamily called N-cadherins. …
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Inhibition of Vascular Smooth Muscle Cell Migration and Intimal Thickening with Chimeric N-Cadherin Mimetic Peptides: Development of a Novel Therapeutic Strategy for Restenosis
… peptide with a mimetic domain for neural (N)-cadherin and a matrix- anchoring domain which binds fibronectin that can be delivered to injured blood vessels to inhibit SMC migration while allowing EC regeneration. This N-cadherin mimetic peptide (NCad peptide) inhibited the migration of rodent …
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Cell culture platforms with cell-cell adhesive ligands for biomedical applications
… cell-cell interactions. One such molecule is N-cadherin, a cell-cell adhesion protein which is expressed on both MSCs and neurons. N-cadherin regulates cytoskeleton organization, mechanotransduction, paracrine function, stem cell development, and neuronal growth. This molecule is an ideal …
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
N-Cadherin plays an important role during dendrite arborisation, axon guidance and synaptogenesys. In particular, at synaptic sites, it is required for activity-dependent synaptic plasticity and dendritic spine remodeling. Recent studies have shown that N-Cadherin can be cleaved by the …
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Cadherin-Mediated Cell-Cell Interactions Regulates Phenotype And Morphology of Nucleus Pulposus Cells Of The Intervertebral Disc
… of these NP cells are not understood. N-cadherin is a cell adhesion molecule that is present in juvenile NP cells, but disappears with age. The goal of this dissertation was to reveal the role of N-cadherin for NP cells in multi-cell clusters that contribute to the maintenance of the …
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Membrane-bound Matrix Metalloproteinases Influence Reactive Synaptogenesis Following Traumatic Brain Injury
… along with their common synaptic substrate N-cadherin, during the period of reactive synaptogenesis. Protein and mRNA expression of MT5-MMP, ADAM-10 and N-cadherin were compared in two TBI models, one exhibiting adaptive plasticity (unilateral entorhinal cortex lesion; UEC) and the other …
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The Impact of pH on the Structure and Function of Neural Cadherin
Neural (N-) cadherin is a transmembrane protein within adherens junctions that mediates cell-cell adhesion. It has 5 modular extracellular domains (EC1-EC5) that bind 3 calcium ions between each of the modules. Calcium binding is required for dimerization. N-cadherin is involved in diverse …
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Nickel Reduces Calcium Dependent Dimerization In Neural Cadherin
Cadherins are the primary transmembrane component in adherens junctions, structures that link the actin cytoskeleton in adjacent cells within solid tissues including neurological synapses, epithelium and endothelium. Cell-cell adhesion by cadherins requires the binding of calcium ions to specific …
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Effects of three-dimensional culture conditions on skeletal muscle myoblasts
… was inhibited by exposure to soluble anti-Neural-cadherin antibody, but this treatment increased MHC levels assessed using immunohistochemistry.\r\nDuring early RCCS culture, myoblasts exhibited numerous cytoplasmic protrusions (podia). Microscopic examination of cells cultured in RCCS and SC …
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Morphological investigations into the development of the mammalian corneal endothelium using the mouse model
… not attained. The expression of adherens (N-cadherin) and tight junction (Z0-1) proteins was investigated by immunoflouresence microscopy. In the normal embryo, the expression of N-cadherin was initially in cytoplasmic vesicles and later at the cell membranes. ZO-l was first detected at the …
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Applications of Traction Force Microscopy in Measuring Adhesion Molecule Dependent Cell Contractility
… in cell spreading, whereas cells plated on N-cadherin-coated substrates. Similarly, cells plated on laminin-coated substrates exhibited substrate stiffness dependent increases in normalized net contractile moment, however the same cells plated on N-cadherin-coated substrates were unable to …
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Differential Expression of Cell Adhesion Molecules by Neuronal Injury
… increased by spinal nerve ligation. N-cadherin mRNA expression was significantly reduced by NMDA in pure cortical neurons and mixed cortical neurons with glial cells. Especially, in pure cortical neurons, NMDA reduced N-cadherin in dose dependent manner, and NMDA receptor antagonist …
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Effect of Tumor Microenvironmental Conditions on Non Small Cell Lung Cancer
… affect the motility of H292 cells. Although N-cadherin, a mesenchymal marker, expression was significantly upregulated by acidic pH, high and low glucose conditions, no direct correlation was observed between N-cadherin expression and motility. E-cadherin expression was not affected by acidic …
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Investigating spatial distribution and dynamics of membrane proteins in polymer-tethered lipid bilayer systems using single molecule-sensitive imaging techniques
… as well as between different cells, through cadherin-based adherens junctions (AJs). Importantly, both types of cell adhesions act as sensitive force sensors, which change their size and shape in response to external mechanical signals. Traditionally, the correlation between adhesion linker …
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PROBING CELLULAR MECHANO-SENSITIVITY USING BIOMEMBRANE-MIMICKING CELL SUBSTRATES OF ADJUSTABLE STIFFNESS
… in the presence of cell-cell-mimicking N-cadherin linkers. Experiments are presented, which demonstrate a relationship between the degree of bilayer stacking and mechanoresponse of plated cells, such as morphology, cytoskeletal organization, cellular traction forces, and migration speed. …
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