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Showing 1 to 20 of 21 for “"N-alkylation"”.
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Development of Fluorine-18 Halofluorination and Fluorine-18 Fluoride Ion Displacement Reactions for the Synthesis of Fluorine-18 Labeled Radiopharmaceuticals (Spiperone, Spiroperidol, N-Alkylation, Radioactivity)
Two fluorine-18 labeling methods, ('18)F halofluorination and ('18)F fluoride ion displacement reactions, have been developed to assess their potential for labeling molecules with the positron-emitting radionuclide fluorine-18 at the no-carrier-added level.
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Oxidation of Alkenes by Caldariomyces Fumago Chloroperoxidase
… factors involved in the control of CPO heme N-alkylation by terminal alkenes, the epoxidation of a series of monosubstituted and 1,1-disubstituted terminal alkenes by CPO was investigated. Terminal alkenes containing a 2-methyl substituent did not inactivate CPO even when the corresponding …
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Formation of Pyrroloindolines and Alkylation of N-heterocycles With Trichloroacetimidates and Synthesis of Quinoline Based Small Molecule Inhibitors of Ghrelin O-acyltransferase (goat)
… synthesized in multiple steps, with their N-alkylation typically requiring the use of stoichiometric strong base which limits the type of electrophile that can be used and generates stoichiometric waste byproducts. Utilizing trichloroacetimidate electrophiles we have initiated an …
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Syntheses of novel acyclic amino-amido ligands
… suitably functionalized intermediates by N-alkylation of diethyl iininodiacetate (70) with appropriate electrophiles are described. The successful functionalization of the pentaamine series of ligands by N-alkylation of (73) withpnitrobenzoyl chloride (118) to give N,N' -bis[2-(N'',N''- …
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New Synthetic Methodologies for the Construction and Optimization of Natural Products
… to starting with 6-aminomanzamine A (17%). N-Alkylation of the aminomanzamines was also problematic because of the instability issue. Utilizing the same reducing system (HOAc/Zn), a simple, mild, cost effective, and green approach for the reductive mono N-alkylation of nitroarenes was …
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Investigation of synthetic methods for preparation of 2<sup>o</sup>-amino derivatives of 5-amino- 1, 10-phenanthroline: Applications to Cu<sup>+2</sup> based impedance sensors
… N-alkyl 5-aphen derivatives. KI- catalyzed mono alkylation of 5-aphen with alkyl halides gave significantly better results than Pd/C catalyzed mono N-alkylation with aldehydes and alkylation of 5-aphen with the PPh3/DDQ system.</p>
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Novel P,N-Ligand Stabilized Transition Metal Complexes as Efficient Catalysts for Organic Syntheses
… and evaluated as potential catalysts for the N-alkylation of amines with alcohols. After optimization of the reaction conditions by systematic variation of important parameters such as solvents, bases or catalyst loadings the possible substrate scope of this method was demonstrated. The obtained …
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Study of Bis-Imidazol-2-Ylidines as Ligands for Transition Metal Catalyzed Coupling Reactions
… phenol and carbonyldiimidazole. Subsequent N-alkylation then furnished the Nheterocyclic carbenes in high yield. Novel unsymmetrical N-heterocyclic carbenes with aryl and benzylic side groups have been synthesized as models for the subsequent synthesis of unsymmetrical polymer-bound …
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Synthesis of some analogues of n-substituted phthalimide and benzo-tetracyanoquinodimethane
… with isopropyl alcohol give products from both N-alkylation and 0-alkylation. Molecular modelling calculations are in line with this observeration.
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Iridium complexes as highly active catalysts for hydrogen isotope exchange and hydrogen borrowing processes
… an efficient method for the room-temperature N-alkylation of anilines. This methodology was also expanded to include the synthesis of N-heterocycles viaintramolecular C-N bond formation, albeit using more forcing conditions. Lastly, a small series of chiral NHC ligands was designed, and their …
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Studies in the synthesis and analysis of novel heterocyclic synthetic cannabinoid receptor agonists
… of a protocol for the regioselective (>99%) N-1 alkylation of the indazole scaffold to generate a wide range of structurally diverse N-1 substituted indazole derivatives in excellent yield (up to 99%). Additionally, the latter optimised N-alkylation protocol is also shown to regioselectively (> …
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Diverse Applications of Flow Technology in Discovery Chemistry
… study resulted from expected modes of O- and N- alkylation, several interesting transformations were uncovered. These included the pseudo-dimerization of homophthalic anhydride, an unusual integration of the van Leusen sulfone, and an unexpected carbon-carbon bond forming event of ethyl …
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A Modular Approach to Highly Functionalized Indole Derivatives and Syntheses of Tryptamine-based SHIP Inhibitors
… friendly method of accomplishing indole alkylation constitutes an important synthetic goal. This dissertation describes modular approaches to constructing densely functionalized indoles, fused heteroaromatic natural products and alkylated tryptamines.</p> <p>The first chapter of the …
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Iridium (III) photosensitisers for photoredox catalysed carboxylation reactions of ketimines
… ligands (L1-L3) were synthesised via standard N-alkylation reactions. Subsequently, two mononuclear cationic bis-cyclometalated iridium(III) complexes (C1, C2) and a new trinuclear iridium(III) complex (C3) were synthesised. The complexes (C1-C3) were obtained as racemic mixtures (Λ, Δ isomers) …
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Trichloroacetimidates As Outstanding Electrophiles for the Carbon-nitrogen, Carbon-oxygen and Carbon-carbon Bonds Formation and Synthetic Studies of Protein Phosphatase-5 (pp5) Small Molecule Inhibitors
… and specialized reaction conditions, while O-alkylation is uncommon and has only been reported utilizing silver salts. These important structures can be alkylated using trichloroacetimidates with a Lewis acid catalyst and the regioselectivity of the alkylation can be varied by changing the …
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AGEing Peptides: Synthesis and Analysis of Peptides Site-Specifically Modified by Advanced Glycation Endproducts
… approach that involved the Fukuyama amino alkylation methodology. Fmoc-pyrraline was synthesised using an efficient pyrrole introduction protocol. Cross-linked building blocks, Fmoc2GOLD and Fmoc2MOLD, were prepared in the Debus-type amino-cyclisation procedure. Incorporation of the AGE …
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Nitrogen-Oxidants Enable Group-Transfer Reactions
… trapped by Michael acceptors for a formal C(3)-alkylation. This process yields products with diastereoselectivity when engaging complex small molecules and enantioenriched Michael acceptors. Thereby, photoredox-mediated C(3)-selective alkylation process affords complementary position selectivity …
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Quantum dot labelled antimalarials and investigation of their interaction with synthetic haemozoin
… of the new group was obtained through a N-alkylation using a Boc protected aldehyde, leading to the formation of the final product by cleaving the Boc group with TFA. CdSe/ZnS quantum dots with carboxylic acid functionalized ligands (QD-COOHs) were obtained from Cytodiagnostics. Thanks to …
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