Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"N-acetyltransferase"”.
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The effects of pulsed static and oscillating magnetic fields on rat pineal serotonin N-acetyltransferase activity
… more specifically the pineal enzyme, serotonin N-acetyltransferase (SNAT), inhibiting the enzyme and thus melatonin production. The enzyme assay required, for performing this type of work is crucial, as the natural decay of the enzyme could bias experimental results. An assay for measuring SNAT …
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Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
… of a cure remains elusive. Inhibition of the acetyltransferase activity of the N-acetyltransferase 10 (NAT10) protein has been shown to have profoundly positive effects on both cellular and mouse models of premature ageing; however, the pathways it is involved in remained largely unexplored. …
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Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
… and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk
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Characterization of the genetic variability of human arylalklamine-N-acetyltransferase (AA-NAT) and its potential effects on melatonin production and the sleep pattern
The human sleep/wake cycle is characterized by a circadian rhythm of circulating melatonin levels, which has been attributed to the cyclic expression of its biosynthetic rate-limiting enzyme, arylalkylamine-N-acetyl-transferase (AA-NAT). Genetic variability of the AA-NAT gene may therefore …
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Investigation of DNA methylation at the promoter region of the aralkylamine N-acetyltransferase (AANAT ) gene in South African children with Autism Spectrum Disorder
… Spectrum Disorder (ASD) traits. Aralkylamine N-acetyltransferase (AANAT) acts as the penultimate and rate-limiting enzyme in the melatonin biosynthetic pathway, and a study by Hu et al. (2009) reported that AANAT expression was suppressed in an ASD population with severe language impairments. …
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Pharmacometric modelling to inform and improve TB and HIV treatment: Focus on drug-drug interactions and neglected populations
… main determinants of drug concentration were N-acetyltransferase 2 and CYP2B6 genotypes, which resulted in a 5-fold difference for both drugs between rapid and slow metabolisers. Bedaquiline exposures were lower during both postpartum and antepartum compared to historical data in non-pregnant …
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Acing nucleic acids and chemistry : exogenous RNA/DNA acetylation and modeling universal data formats.
… of the primary amine of cytosine by an N-acetyltransferase with acetyl-CoA as the acetyl donor. This highly conserved modification is involved in RNA stability and translation efficacy. The natural acetylation of RNA poses the question: can the nitrogenous bases of RNA and DNA nucleotides …
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Directed Evolution of Phosphite Dehydrogenase and Engineered Biosynthesis of Fr-900098
… transferase-decarboxylase (FrbH), an N-acetyltransferase (FrbF), a novel amide hydroxylase (FrbG), and a promiscuous nucleotide hydrolase (FrbI). The presence of cytidine 5'-monophosphate (CMP) conjugated phosphonate intermediates in the pathway also gives fascinating new insights into …
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Toward the synthesis and evaluation of novel N-acylated FR-900098 analogs
… here, we have studied and characterized the N-acetyltransferase FrbF from the FR-900098 biosynthetic pathway, which was recently completely reconstituted in E. coli. This enzyme is responsible for transfer of the acetyl group from acetyl-CoA to the phosphonate substrate, representing the …
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Plant Activation of Bicyclic Aromatic Amines, Benzidine and 4-Aminobiphenyl
… by plant-activation. Bacterial acetyl O-acetyltransferase as well as human N-acetyltransferase play a key role in the activation of benzidine and 4-ABP, and bacterial nitroreductase is partially involved in the mutagenic activation in Salmonella typhimurium. The mutagenic plant-activated …
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Effect of Photoperiod on Developmental Morphology and Enolase Isoenzyme Immunohistochemistry in Rat and Djungarian Hamster Superficial Pineal Glands
… (HIOMT) and serotonin N-acetyltransferase (SNAT). Increased levels of the glycolytic enzyme neuron-specific enolase (NSE) are thought to reflect increased physiological demands placed on neurons and neuroendocrine tissues. Homodimer non-neuronal enolase isoenzyme (NNE) is …
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Towards the Characterization of Enzymes Involved in the Metabolism of Tyrosine and Tyrosine Derivatives
… order to function properly. The hypothetical N-acetyltransferases from Aedes aegypti were used as model proteins for investigation of tyrosine derivative metabolism. We found nine potential arylalkylamine N-acetyltransferase (AANAT) genes in Ae. aegypti. Phylogenetic analysis suggests that these …
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Characterisation of the molecular complexes that regulate the G2/M checkpoint of the eukaryotic cell cycle
… this complex may be similar to the serotonin N-acetyltransferase/14-3-3ζ complex. Experiments to determine the structure experimentally, using either TEM or x-ray crystallography, were unsuccessful, as the complex appeared to exhibit a high degree of flexibility in solution. CDC25B was also …
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Development of Novel Biosensor Platforms for Point-Of-Care (POC) Diagnostics
… and optimization for the detection of the N-acetyltransferase 2 (NAT2) gene. The GFET biosensors were evaluated for their ability to detect changes in the amplification process with a shift in the Dirac point of 150 mV for the 30 min reaction, indicating production of amplified products from …
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"Sugar Coat" Genetic & chemical validation of <i>Aspergillus fumigatus</i> cell wall targets
… exploitation of glucosamine-6-phosphate N-acetyltransferase (GNA1) an enzyme in the highly conserved UDP-GlcNAc biosynthetic pathway is an elegant means of targeting chitin synthesis upstream by inhibition of the sugar nucleotide substrate UDPGlcNAc. Finally, UDP-galactopyranose mutase …
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Natural product discovery and engineering at the protein, pathway, and genome scales
… and biochemical characterization of the N-acetyltransferase FrbF and the corresponding target for FR-900098 inhibition, Dxr from Plasmodium falciparum, we show that the novel FR-900098 derivatives can serve as more potent inhibitors. A platform for their biosynthesis is also established in …
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Vliv dihydromyricetinu a myricetinu na vybrané biotransformační enzymy
Flavonoidy jsou přírodní látky běžně přijímané v rostlinné potravě. Jsou jim přisuzovány pozitivní účinky na lidský organismus, především antioxidační, hepatoprotektivní a protirakovinné účinky. V současnosti je možné konzumovat vysoké koncentrace těchto látek ve formě potravních doplňků. Není však …