Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"N-acetylneuraminic acid"”.
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EFFECT OF DIETARY GLYCOMACROPEPTIDE AND CHOLESTEROL ON CORTICAL GANGLIOSIDE- AND GLYCOPROTEIN-BOUND N-ACETYLNEURAMINIC ACID IN YOUNG RATS
Background: Sialic acid and cholesterol are present in human milk and accumulate rapidly in the brain during development. Infant formulas contain little sialic acid or cholesterol. Sialic acid and cholesterol supplementation increase cortical ganglioside and glycoprotein sialic acid and cholesterol …
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Chemoreceptors Regulate Discharge of Microbasic p-mastigophores in the Sea Anemone, AIPTASIA PALLIDA
… were shown to interact with glycine and N-acetylneuraminic acid (NANA). We now show that the discharge of the microbasic p-mastigophores, one of the three types of cnidae present on the tentacles of A. pallida, is under the controlling influence of these two classes of cnidocyte-associated …
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LECTINS FROM THE HORSESHOE CRAB, LIMULUS POLYPHEMUS, REACTIVE WITH BACTERIAL LIPOPOLYSACCHARIDE
… (KDO) have supported the hypothesis that this acidic residue is the immunodeterminant group in the core region of the lipopolysaccharide molecule. Limulus also contains a lectin which interacts with the lipid A region of lipopolysaccharide; the proposed binding site in this region is the …
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Cloning and characterization of neuraminidase from Salmonella typhimurium LT-2 and its relationship to neuraminidase from other bacteria
… because of their ability to cleave sialic acid residues from host glycoconjugates. The gene encoding NANase (nanH) from Salmonella typhimurium has been cloned and its protein product purified. The purified NANase is 41.3 kD with an isoelectric point of approximately 9.0. The enzyme does not …
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Mechanisms and measurements of sialidase in pneumonia
… on the host cell walls to release N-acetylneuraminic acid (sialic acid) and lactose. This aids the bacterial adhesion which contributes to the overall virulence of the pathogen. Thus, one aim of the pharmaceutical industry is to design and develop inhibitors for these enzymes. …
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Phylogenetic distribution of CMP-Neu5Ac hydroxylase (CMAH), the enzyme synthetizing the pro-inflammatory human xeno-antigen Neu5Gc
The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for thesynthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surfaceproteins of most deuterostomes. The CMAH gene is thought to be present in mostdeuterostomes, but it has been inactivated in a …
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Receptor Binding Domains and Coronavirus Adaptation and Evolution
… of HCoV-OC43 in complex with 9-O-Acetyl-N-acetylneuraminic acid (Neu5,9Ac2). In addition, viral sequence analysis, binding studies, and comparative sequence and structural analysis among closely related coronaviruses were performed. The observation that the greatest variability shown by …
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SERS-based nanoparticle biodetection using carbohydrate-lectin interactions
… non-specific aggregation. The carboxylic acid functionality of the PEG molecules used allowed for subsequent coupling of a variety of carbohydrates to the nanoparticle surface. This resulted in the production of glyconanoparticles with unique surface functionality, for example, glucose or …
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Identification and characterization of an enterocyte receptor for group A porcine rotavirus
… by Sephadex partition, ion exchange, silicic acid, and thin-layer chromatography, blocking activity behaved as a monosialylganglioside (GMX) that displayed a thin-layer chromatographic mobility between that of GM2 and GM3. Inhibition of blocking activity by treatment of GMX with neuraminidase …
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The Roles of Ca2+ and cAMP in the Nematocyst Discharge of the Sea Anemone Tentacle
… respond to N-acetylated sugars, such as N-acetylneuraminic acid (NANA), which occur on prey surfaces. When stimulated, this chemosensory pathway sensitizes CSMs to trigger nematocyst discharge in response to physical contact.</p> <p>Indirect evidence suggested that the NANA chemosensory …
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Metabolic Pathways for Natural and Unnatural Sialic Acids
Carbohydrates, along with lipids, nucleic acids, and amino acids constitute the four main building blocks of life. This thesis will focus on sialic acid, a unique, nine-carbon sugar that is critically important in humans. In Chapter 1, I will introduce sialic acid biology and the many diseases that …
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Targeted and untargeted metabolomic profiling of human serum, urine and brain by liquid chromatography mass spectrometry (LC-MS)
… acyl carnitines. Some metabolites including bile acids and several amino acids were subject to diurnal variation during the rest day (day 1). Using OPLS modelling it proved possible to identify a single abundant urinary metabolite provisionally identified as oxo-aminohexanoic acid (OHA) as being …