Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 48 for “"N-acetylcysteine"”.
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Effects of n-acetylcysteine amide in preventing/treating cataracts
… the efficacy of a thiol antioxidant, (R) -N-acetylcysteine amide (NACA), in preventing/reversing cataracts. To investigate NACA's ability to provide therapeutic benefits for cataracts, three different experimental models were utilized. The first was an ex-vivo cataract model, where culturing …
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Complex Formation of Pb(II) with Cysteine, Penicillamine and N-acetylcysteine
The mechanism of lead poisoning and interest in metal toxicity has been a growing area of study since the late 1950s. In order to gain insight on how toxic metals behave physiologically, simple molecules can first be used to model the environments. Complex formation between Pb(II) and …
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Therapeutic effects of N-acetylcysteine amide in the treatment of eye disorders
… research has shown that an antioxidant called N-acetylcysteine amide (NACA) not only acts as an antioxidant itself but also stimulates the production of glutathione thereby increasing resistance to oxidative stress. To evaluate NACA's ability to provide therapeutic benefits in eye-related …
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Microfluidic-engineered N-acetylcysteine crystals for oxidative stress control and biologics manufacturing
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-09-01 without embargo terms
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N-Acetylcysteine for non-paracetamol drug-induced liver injury: A systemic review
… options for drug-induced liver injury (DILI). N-acetylcysteine (NAC ) is known to be of benefit in management of DILI due to paracetamol overdose and may also be useful in the management of non-paracetamol DILI. Our objective was to systematically review evidence for the use of NAC as a …
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Mitigating oxidative stress in childhood cerebral adrenoleukodystrophy -an investigation of N-acetylcysteine pharmacology
… group at University of Minnesota has utilized N-acetylcysteine (NAC) as adjunctive therapy together with HSCT in late-stage CCALD. This combinatorial approach has improved survival rate from 36% to 84% compared to HSCT only in a cohort study (Miller et al., 2011). However, NAC's mechanisms of …
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Efficacy of N-acetylcysteine on Prevention and Amelioration of Cisplatin-induced Ototoxicity: A Systematic Literature Review
<p>Objective: The purpose of this investigation is to perform a systematic review of the existing literature on NAC efficacy in prevention of cisplatin-induced ototoxicity.</p> <p>Methods: A comprehensive search utilizing databases via the Mina Rees Library of the Graduate Center of the City …
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The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans
… fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated …
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Role of glutamate in lead-induced toxicity: protection by N-acetylcysteine amide (NACA), a novel thiol antioxidant
"Despite several efforts to reduce lead levels in the environment, lead exposure continues to be a major public health problem, in the US today. Toxic effect of lead are mainly manifested in central nervous system (CNS) because brain acts as a reservoir for lead deposition. Lead-induced cell damage …
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A randomised controlled trial of N-acetylcysteine in the management of anti-tuberculosis drug-induced liver injury
… of first-line anti-tuberculosis therapy (ATT). Nacetylcysteine (NAC) has efficacy in patients with paracetamol toxicity, and may be of benefit in liver injury due to other causes, such as ATT-induced liver injury (AT-DILI). Rechallenge of first line ATT after liver injury is usually attempted and …
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Clinical outcomes in patients with paracetamol ingestion treated with a two-bag n-acetylcysteine regimen in the emergency centre of khayelitsha hospital
… ingested for intentional self-poisoning. N-acetylcysteine (NAC) is administered to patients at risk of developing hepatotoxicity and was historically administered using a three-bag intravenous regimen. A change towards a two-bag NAC regimen was initiated at Khayelitsha Hospital. The aim of …
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Nanotechnology based therapeutic approaches to iron‐induced oxidative stress in an in vitro model of Parkinson’s disease
… delivery systems of the antioxidants curcumin, n‐acetylcysteine (NAC) and hydroxytyrosol (HT), alone or combined with the iron chelator deferoxamine (DFO), to protect against rotenone‐induced parkinsonism in SH‐SY5Y cells, and in a co‐cultured hCMEC/D3 ‐ SH‐SY5Y cellular BBB model. In Parkinson’s …
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A comprehensive study of the impact of contrast medium on endothelial cells in vitro: validating the protective effects of n-acetylcysteine and assessing the importance of endothelin-1 and glutathione on contrast-induced nephropathy in patients with chronic kidney disease
… aiming to assess the therapeutic potential of N-acetylcysteine (NAC) as an antioxidant therapy/prophylactic to lower the impact of CM infusion on renal function. The results obtained suggested that oral NAC treatment may prevent a CM-induced ET-1 increase in patients at risk of CIN. However, NAC …
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A Microfluidic Approach For Investigating The Role Of Blood Flow In Thrombosis
… and VWF deposition was markedly decreased when N-acetylcysteine was added. In contrast, inhibition of fibrin polymerization did not change the overall structure of the thrombi, suggesting VWF is more important to clot stability at stagnation points. N-acetylcysteine was found to reduce deposition …
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Quercetin and chloroquine synergistically induces cell death in glioma cells via the increase of Ca2+ and ROS levels
… ROS levels and their scavenging using N-acetylcysteine or GSH markedly inhibited the cell death by the combined treatment. Taken together, combined treatment with quercetin and CQ induces cell death via the increase of Ca2+ and ROS levels in glioma cells.
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Sulforaphane sensitizes TRAIL-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated upregulation of DR5
… of reactive oxygen species. Pretreatment with N-acetylcysteine and overexpression of catalase inhibited SFN-induced upregulation of DR5 and almost completely blocked the cotreatment-induced apoptosis. Furthermore, the SFN-mediated sensitization to TRAIL was efficiently reduced by administration …
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The role of potential antioxidant in medicinal drug-induced oxidative stress
… alleviate the toxicity induced by these drugs. N-acetylcysteine (NAC), a synthetic thiol, is a free-radical scavenger and a precursor of glutathione (the main endogenous antioxidant). However, the negative charge of NAC at physiological pH limits its bioavailability. N-acetylcysteineamide (NACA) …
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Developmental origins of cortical circuit dysfunction in a 22q11 deletion mouse model
… neurite growth. Treatment with the antioxidant N-acetylcysteine (NAC) improved axonal and dendritic growth but did not restore expression of deleted or differentially expressed genes in LgDel PNs. Instead, NAC induced a distinct antioxidant response via Nrf2 signaling pathway. Together, these …
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A study of the beneficial role of thiol antioxidant supplementation in various forms of glutathione deficiency
… evaluate the abilities of a thiol antioxidant, N-Acetylcysteine amide (NACA), to protect cells from the harmful effects of glutathione depletion in two different models of oxidative stress. The first model represented oxidative stress processes in age-related macular degeneration. This part of the …
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