Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"N-Myc"”.
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Targeting the N-myc oncoprotein using nanobody technology
The myc family of oncogenic transcription factors, which includes c-myc, N-myc and L-myc, control major cellular processes such as proliferation and differentiation by integrating upstream signals and orchestrating global gene transcription. They do this largely through dimerising with Max, which …
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The novel long noncoding RNA lncUSMycN in N-Myc-induced oncogenesis
… of a 130 kb genomic DNA region containing the MYCN oncogene. While MYCN has been extensively investigated, it is unknown whether other genomic elements within the 130 kb amplicon play a role in neuroblastoma. In this study, I experimentally validated the novel long noncoding RNA up-stream of …
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Functional analysis of N-MYC downstream regulated gene 1 (NDRG1) in Oesophageal squamous cell carcinoma
… we describe our work analysing the function of N-myc downstream regulated gene 1 (NDRG1, also known as Cap43 or Drg-1) in the neoplastic progression and maintenance of OSCC. Although NDRG1 has previously been implicated in breast, prostate, colon and liver carcinoma, the exact role of NDRG1 in …
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Expression and Clinical Significance of the N-myc downstream regulated gene-1 in Hypopharyngeal Cancer
"Expression and Clinical Significance of The N-myc downstream regulated gene-1 in Hypopharyngeal Cancer Objective. N-myc downstream regulated gene-1 (Ndrg-1), a potent metastasis suppressor gene, is identified as a gene that is up-regulated by the induction of differentiation in various cancer cell …
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Targeting Transcription Factors in Neuroblastoma: Development of Aurora Kinase A/N-Myc Degraders and ID2 Chemical Probes
… using targeted protein degradation. N-Myc overexpression is the most frequent driver in neuroblastoma. Unique features of N-Myc biology offer innovative approaches for developing chemical modulators of this oncogenic TF. For example, N-Myc is stabilized from proteolytic degradation in …
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Expression and regulation of N-Myc Downstream- Regulated gene 1 in squamous cell carcinoma of the oesphagus
… described the overexpression of N-Myc Downstream-Regulated Gene 1 (NDRG1) in oesophageal squamous cell carcinoma (OSCC) tissue compared to normal tissue in a cohort of South African cancer patients. Despite more than ten years of research into the role of NDRG1 in cancer, the …
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Finding the Best Gene Candidate(s) as a Potential Therapeutic Target for N-MYC Overexpressing Neuroendocrine Prostate Cancer (NEPC)
… regulate the development of NEPC cells is the N-MYC oncogene, along with the loss of tumor suppressors such as TP53 and RB1 (Lee et al., 2016). Resistance to current treatments results in the transformation of prostate cancer (PC) cells into Castration-resistant prostate cancer (CRPC), which at …
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The critical role of histone methylation in tumour progression and as anti-cancer targets in neuroblastoma
N-Myc induces neuroblastoma by regulating the expression of target oncogenes. Histone H3 lysine 79 (H3K79) methylation at Myc-responsive elements of target gene promoters is a strict prerequisites for Myc-induced transcriptional activation. DOT1L is the only known histone methyltransferase that …
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The study of sonic hedgehog signaling pathway in the development of lysosomal acid phosphatase (Acp2) mutant mice cerebellar granule cells
… the cerebellum. The sonic hedgehog (SHH) and N-Myc pathways are important for granule cell precursor proliferation and differentiation. The project tests the hypothesis that the proliferation defect of granule cells is associated with SHH - N-Myc pathway impairment in the nax mutant cerebellum. …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
… a non-catalytic stabilizing scaffold for N-Myc, the protein product of the MYCN gene, which is heavily amplified in many childhood neuroblastomas and late-stage neuroendocrine prostate cancers. A strategy to block growth of cells harboring MYCN amplification is to disrupt complex formation …
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Investigating the Fate of Pre-neoplastic Cells in a Mouse Model of Medulloblastoma
… not form tumors is differentiation. Moreover, N-myc, a gene commonly amplified in medulloblastoma, can dramatically alter the fate of PNCs, preventing differentiation and driving progression to tumors. Importantly, N-myc allows PNCs to grow independently of hedgehog signaling, making the …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… neuroblastoma cells via direct binding of the N-Myc transcription factor to Sp-1 sites on the TβRIII promoter. Analysis of patient microarray data demonstrate that other members of the differentiating stroma secretome, including HBEGF and EGFR, are positively correlated with TβRIII expression, …
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Inibizione selettiva del gene MYCN mediante PNA (acidi peptido nucleici) anti-gene nel rabdomiosarcoma umano
MYCN oncogene amplification/expression is a feature of many childhood tumors, and some adult tumors, and it is associated with poor prognosis. While MYC expression is ubiquitary, MYCN has a restricted expression after birth and it is an ideal target for an effective therapy. PNAs belong to the …
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Androgen Regulation of Gene Expression Associated with Cell Growth and Neural Plasticity: Studies in Songbird Brain and the S115 Cell Line
… of c-jun and two other proto-oncogenes (c-myc and n-myc) in RNA from tissue containing HVc and surrounding telencephalon. Because of this lack of a more dramatic effect in the complex tissue of the brain, I also quantified changes in gene expression induced by androgens in a simpler system. …
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The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity
… found that WT1 upregulated the expression of N-myc downstream regulated gene 2 (NDRG2) and downregulated interferon regulatory factor 8 (IRF-8). Using a bacterial II hybrid assay, we also identified cofilin 1 as a novel protein partner of WT1. Our data also indicate that BCR/ABL1 induce …
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Deciphering the Functional Collaboration of Mid and bric-a-brac 2 as Potential Regulators of Cellular Proliferation Within Adult <i>Drosophila</i> Ovaries
… with a concomitant decrease in <em>N-myc-1 </em>expression, a proto-oncogene. These disturbed signaling events induce hypoplasia [9].</p> <p>The Leal lab undertook a genetic modifier screen and discovered that <em>mid</em> interacts with several genes implicated in the control of …
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Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
… of two other Skp2 substrates, p21 and N-myc, to varying degrees. A number of different approaches were taken to deliver the CPs into cells and investigate their effect on p27 protein levels and on cellular proliferation. CPs were able to restore p27 levels associated with Skp2 …
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Functional Analysis of the Tumor Metastasis Suppressor, NDRG1
… tumor. Previously, we identified NDRG1 (N-myc downstream regulated gene 1) as a tumor metastasis suppressor gene and found that it is negatively involved in metastatic progression of prostate and breast cancers. To elucidate the molecular mechanism of NDRG1 function, we used the yeast …
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