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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 23 for “"N-Methyl-D-Aspartate Receptor"”.

  1. Regional and temporal differential regulation of the N-methyl-D-aspartate receptor by phencyclidine during development

    Noelle Catherine AnastasioThe University of Texas Medical Branch2005

    … phencyclidine (PCP)-induced changes in the NMDA receptor subunit composition and the relationship of these changes to the deficits in pre-pulse inhibition (PPI) caused by PCP treatment. Postnatal rats were treated with atypical or typical antipsychotics or selective dopamine or serotonin receptor …

    utmb Repository record

  2. Effects of N-Methyl-D-Aspartate receptor blockade on cross-sensitization between D-Tyr11 neurotensin and amphetamine

    Mograss, Melodee A2001

    Blockade of neurotensin (NT) receptors with SR-48692 prevents the development of sensitization to the locomotor activating effects of amphetamine (AMPH). In addition, repeated icv injections of NT or of its analog, D-Tyr 11 NT, sensitize animals to the locomotor activating effects of AMPH. Recent …

    concordia Repository record

  3. Effects of perinatal phencyclidine treatment on neuronal viability, N-methyl-D-aspartate receptor regulation and schizophrenic-like behaviors

    Noelle Catherine AnastasioThe University of Texas Medical Branch2009

    … its major actions as a noncompetitive NMDA receptor (NMDAR) antagonist. Administration to immature rats has been shown to cause neurotoxicity in a regional and treatment dependent manner and development of schizophrenic-like behaviors later in life. The purpose of this study is to determine …

    utmb Repository record

  4. In vitro and in vivo radioligand binding studies for the n-methyl-d-aspartate receptor and the 5-hydroxytryptamine transporter

    Shirakawa, KiyoharuThe University of Edinburgh1996

    edinburgh Repository record

  5. Modulation of long-term potentiation by the glycine site of N-methyl-D-aspartate receptor in rat hippocampal CA1 pyramidal cells

    Krasteniakov, NicholasCarleton University2004

    carleton Repository record

  6. Regulation of Excitatory Neurotransmission, Synaptic Plasticity, and Learning by Cyclin-Dependent Kinase 5

    Hawasli, Ammar Hamami2010

    … genetically enhanced mice displayed increased N-methyl-D-aspartate receptor-mediated currents and elevated levels of the NR2B N-methyl-D-aspartate receptor subunit. The enhancement in synaptic plasticity was directly attributed to the increased current through NR2B-containing receptors. NR2B …

    utswmed Repository record

  7. Targeting NMDA Receptors to Tune Corticothalamic Circuit Function

    Chen, YangVirginia Tech2023

    … (nRT)-VPM pathway. This work revealed novel N-methyl-D-aspartate receptor (NMDAR) nucleus-specific and frequency-dependent functional diversity in the somatosensory CT circuit. Specifically, these findings illustrate the different effects of NMDAR negative modulation in the nRT and the VPM, …

    vt Repository record

  8. Ethanol priming and its effects on consumption and accumbal plasticity

    Meyers, Tira AnneThe University of Texas at Austin2015

    … divided into two subpopulations of D1-dopamine receptor (D1) or D2-dopamine receptor (D2) expressing medium spiny neurons (MSNs) that precipitate different intracellular cascades and actions upon the reward circuitry. Alterations in the expression N-methyl-D-aspartate receptor (NMDAR)-dependent …

    texas Repository record

  9. Discovery of heat shock protein90 inhibitors using structured-based virtual screening

    Ngcagawule, SiyasangaUniversity of the Western Cape2023

    … Cholinesterase inhibitors (ChEIs) and N-methyl-D-aspartate receptor (NMDAR) antagonists are current treatment options for mild to moderate AD. These agents are not used to cure the illness, but rather as symptomatic therapy. Heat Shock Protein (HSP90), is one of the molecular chaperones …

    western-cape Repository record

  10. Excitotoxicity, oxidative stress and neuroprotection in cerebellar granule neurones

    Smith, Andrew JohnUniversity of Glasgow2008

    … stress considered the effects of glutamate, N-methyl-D-aspartate, 3-nitropropionic acid and oxygen-glucose deprivation. Additionally, extensive study was carried out of the actions of increased glucose concentration and a range of metabolites of the essential amino acid tryptophan. It was …

    glasgow Repository record

  11. Neuroprotection from the huntingtin-repressed transcriptional coactivator PGC-1α

    Puddifoot, Clare AnneThe University of Edinburgh2013

    … of HD reduces neuronal volume loss. Synaptic N-methyl-D-aspartate receptor (NMDAR)- activity can drive the expression of PGC-1α which is neuroprotective against oxidative and excitotoxic stress in vitro whereas extrasynaptic NMDAR expression is increased in HD. Excessive NMDAR activity, …

    edinburgh Repository record

  12. Role of the PI-3K/Akt and ERK pathways in phencyclidine-induced neurotoxicity in neonatal rats and the protection by lithium and BDNF

    Yan XiaThe University of Texas Medical Branch2009

    Phencyclidine is an N-methyl-D-aspartate receptor (NMDAR) open channel blocker that causes schizophrenia-like symptoms in healthy humans and exacerbates psychoses in schizophrenics. In animals, PCP administration to immature rats causes wide spread neuronal death during brain development and …

    utmb Repository record

  13. Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area

    Ramsey, Leslie AnneUniversity of Texas at Austin2012

    … enhances long-term potentiation (LTP) of N-methyl D-aspartate receptor (NMDAR)-mediated glutamatergic transmission in the VTA. Activation of NMDARs is critical to the generation of DA neuron bursts that encode rewards and reward-predictive cues, and NMDARs are necessary for associative …

    texas Repository record

  14. Biological Monitoring of Oxygen and Nitric Oxide: The Development and Characterisation of Real-Time Microelectrochemical Sensors.

    Wynne, Andrea M.National University of Ireland Maynooth2014

    … the brain, the biosynthesis of NO through the N-methyl-D-aspartate receptor (NMDA) and the potential role of NO in neurovascular coupling. Chapter 2 discusses the theory behind the project and Chapter 3 describes the experimental protocols utilised throughout this research. Chapter 4 discusses …

    maynooth Repository record

  15. Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity

    Smith, Gordon BrawnMassachusetts Institute of Technology2010

    … via a decrease in the ratio of NR2A to NR2B N-methyl-d-aspartate receptor (NMDAR) subunits. Facilitated by the decreased modification threshold, open-eye responses are strengthened via homosynaptic longterm potentiation (LTP). One established LTD mechanism is a loss of sensitivity to the …

    mit Repository record

  16. Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder

    Gideons, Erinn Sommer2018

    Ketamine is a N-methyl-D-aspartate receptor (NMDAR) antagonist that elicits rapid antidepressant responses in depressed patients. However, ketamine can also produce psychotomimetic effects, which limits its widespread use. The field has been exploring the mechanism of ketamine's antidepressant …

    utswmed Repository record

  17. Unmasking Impulsivity as a Glutamatergic Dysfunction Phenomenon: Presynaptic and Postsynaptic Considerations

    Davis-reyes, Brionna DanielleThe University of Texas Medical Branch at Galveston2020

    … impulsivity) is characterized by imbalances in N-methyl-D-aspartate receptor (NMDAR) expression and synaptic targeting and stabilization. To test the hypothesis that high motor impulsivity is driven by GluR dysfunction, we administered ketamine, a NMDAR channel blocker that induces synaptic …

    utmb Repository record

  18. Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.

    George, JojuCreighton University2010

    … and synaptogenesis are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. Inasmuch as neuronal activity involves activation of voltage-gated sodium channels (VGSCs) primarily, in this study, we used a sodium channel activator, brevetoxin-2 (PbTx-2) to …

    creighton Repository record

  19. Selective Molecular Modification to Calcium Conductance Domains of NMDA Receptor GluN2 Subunits Regulates Maturation of Hippocampal Behavior

    Sanders, Erin Morgan2014

    gmu

  20. Gut-brain axis: Central impact of gut peptides and metabolic drug on monoamine neurotransmission

    Omoloye, AdesinaDe Montfort University2019

    … and the stable glucagon-like-peptide-1 (GLP-1) receptor agonist exendin-4 as well as putative GLP-1 congener geniposide, can affect the electrical activity of dopamine neurons in the ventral tegmental area (VTA) and of pyramidal neurons in the prefrontal cortex (PFC), using single-unit activity …

    de-montfort Repository record

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