Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"N-Acetyl Cysteine"”.
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Severely Stressed Astrocytes Adapt to Injury and Still Protect Neighboring Neurons
… 2, we examined the therapeutic potential of N-acetyl cysteine, a glutathione precursor known to benefit patients with neurological disorders. We discovered that N-acetyl cysteine protected astrocytes from proteotoxic stress independent of glutathione. Instead, the protection afforded by …
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The Influence of Age, Gender, and Thiol Repletion in an In Vivo Model of Lewy Body Disorders
… hastened mortality in aged mice. In Aim 3, N-acetyl cysteine protected primary neuron cultures against proteotoxicity, including that of α-synuclein fibrils, and the mechanism appeared to be partly dependent on the chaperone activity of heat shock protein 70. These findings were expanded to an …
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Reactive Oxygen Species are Second Messengers in the Lysophosphatidic Acid Induced Survival Signaling of Ovarian Cancer
… ERK, and NF-κB activation. Two antioxidants, N-acetyl-cysteine (NAC), curcumin, and EUK-134 each considerably reduced cell proliferation, as well as NF-κB activity. EUK-134 also diminished LPA-stimulated Akt and ERK activation. We observed that these signaling pathways were similarly abolished …
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Influence of the Vitamin D3 Analog EB 1089 on Senescence and Cell Death Pathways in the Response of Breast Tumor Cells to Ionizing Radiation
… however, both free radical scavengers, N-acetyl cysteine (NAC)and reduced glutathione (GSH), fail to attenuate the radio-sensitizing effects of EB 1089. These studies rule out increased radiation-induced DNA damage, inhibition of DNA repair, inhibition of myc suppression,or increased ROS …
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The Role of Reactive Oxygen Species in Crotalus atrox Venom-induced Cell Death
… over time than other treatments including N-acetyl cysteine (NAC), SOD1 inhibitor LCS-1, and NOX inhibitor VAS2870. This suggests hydrogen peroxide is 3 produced during venom induced injury and plays a critical role in venom mediated cell death.</p>
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Acute hypoxia-induced diaphragm dysfunction is prevented by antioxidant pre-treatment
… A separate group of mice were administered N-acetyl cysteine (NAC; 200mg/kg, I.P.) immediately prior to acute hypoxia exposure. Ventilation was assessed using whole-body plethysmography. O2 consumption and CO2 production were measured as indices of metabolism. Diaphragm muscle contractile …
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Dendrimer Based Nanotherapeutics For Ocular Drug Delivery
… drugs Triamcinolone acetonide (TA) and N-Acetyl Cysteine (NAC) conjugated to G4-OH dendrimers showed tailorable sustained release in physiological relevant solutions and were evaluated in-vitro and in-vivo. Dendrimer-TA conjugates enhanced the solubility of TA and were 100 fold more …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… The effects of antioxidant, trolox, and N-acetyl-cysteine (NAC) as well as siFoxO3a transfection also mimicked those effects of OE, Quer, YE, and HSP. However, transfection of siFoxO3a did not inhibit transcription of MMP-9 and redistribution of ZO-1 induced by hypoxia. In addition, OE, …
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The Metabolic Fate of Glucoraphanin in F344 Rats
… of SF, erucin and erysolin, respectively, as N-acetyl cysteine conjugates in the urine. Slightly less than half of the GP given ip was found in urine either unchanged or as its reduced from, glucoerucin. Further investigation of GP metabolism was conducted using an in vitro fermentation model. …
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Oxidative stress mechanisms within the developing porcine oocyte and the effects of antioxidant supplementation
… to evaluate the effects of glutathione (GSH), N-acetyl-cysteine (NAC), and N-acetyl-cysteine-amide (NACA) supplemented to the maturation medium on intracellular GSH concentrations, nuclear maturation, fertilization success and embryo development. Antioxidants GSH, NAC and NACA (1.0 mM) were …
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Microdevices for Isolating Single Axons for the Study of Axonal Transport in Dopaminergic Neurons
… chloride: MnTBAP), as well as the anti-oxidant N-acetyl-cysteine: NAC). However, addition of calcium ion chelator, ethylene glycol tetraacetic acid: EGTA), did not restore mitochondrial transport. This study suggests that transport dysfunction occur early and may play a significant role in …
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Topographical Differences in Stress Vulnerability in Experimental Parkinson's Disease
… by facilitating glutathione synthesis with N-acetyl cysteine. Finally, as aging is a natural model of protein misfolding stress, the levels of select heat shock proteins, proteasome subunits, and glutathione were examined in neocortex and allocortex in vivo as a function of age. Our findings …
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Regulation of cancer progression by hepatitis B virus X protein (HBx) and HBxAP/RSF1
… protein levels at the translational level 7 3. Cysteine residues of HBx are essential to maintain protein stability . 9 4. Cysteine null mutant of HBx is insufficient for transactivation activities 12 5. Cysteine null mutant is not affected by catalase or N-acetyl cysteine 12 6. Cysteine …
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Roles of the TORC1 Signaling in Stress Response and Chronological Lifespan Extension in Yeast
… only be partially rescued by supplementing N-acetyl cysteine to the cell cultures. These findings supported that the accumulation of storage carbohydrates and the activation of the anti-oxidant defence system are both important for genomic stability and CLS extension of wild-type cells and …
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The Cardioprotective effect of a Lanosteryl Triterpene from Protorhus Longifolia on H9c2 Cardiomyoblasts
… exposed to HG were treated with RA3 (1 μM), n-acetyl cysteine (NAC, 1 mM), metformin (MET, 1 μM), a combination of MET+RA3 (both at 2 μM) as well as MET+NAC (at 2μM and 2 mM, respectively) for a further 24 hrs. Time and dose response as well metabolic activity were assessed using ATP assays. …
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Selective Elimination of Malignant Melanoma Using The Novel Anti-Tumor Agents, Osw-1 and Peitc
… [1→3]-2-<em>O</em>-acetyl-α-l-arabinopyranoside (OSW-1) and β-Phenylethyl Isothiocyanate (PEITC) in melanoma.</p> <p>OSW-1 inhibited melanoma cell viability at nanomolar concentrations with minimal toxicity to normal melanocytes. Mechanistic studies revealed that …
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The androgen receptor independent mechanism of toxicity of the novel anti-tumor agent 11[beta]-dichloro
… that cotreatment with antioxidants such as N-acetyl cysteine or vitamin E alleviates the toxicity of 11[beta]-dichloro, suggesting that ROS play an important role in the mechanism of toxicity. In terms of transcriptional responses, previous observations were confirmed that 11[beta] -dichloro …
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Low Reactive Oxygen Species and High Glycolysis In Glioblastoma Stem Cells:Mechanisms and Therapeutic Implications
… Neutralization of ROS by antioxidant N-acetyl-cysteine in the serum-treated GSCs suppressed the increase of superoxide and partially rescued the expression of SOX2, Olig2, and Notch1, and prevented the serum-induced differentiation phenotype. Additionally, GSCs showed high dependence on …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… assay was then used to determine the role of N-acetyl-cysteine (NAC), towards regulating reactive oxygen species (ROS) and reversing cellular-level changes associated with our DC model. We found that DC model cardiac myocytes exhibited greater incidences of diastolic, but not systolic, …
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