Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Myxoma"”.
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Treatment of murine tumors with recombinant Myxoma viruses
… proteins of interest within the tumor bed. Myxoma virus (MYXV), a rabbit-specific poxvirus, was evaluated as an oncolytic viral treatment for cancer in immunocompetent mouse models of cancer. In addition, a recombinant MYXV that expresses the murine gene for interleukin 15 (IL-15) was also …
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Functional analysis and development of novel marked vaccines against Myxoma virus
En esta tesis doctoral se propuso desarrollar una herramienta para controlar la enfermedad, basada en una vacuna DIVA, para lo cual se postuló la construcción de un virus mixoma recombinante marcado por deleción de un gen antigénico, además de una prueba serológica diferencial capaz de distinguir …
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Enhancing efficacy of oncolytic myxoma virus and adoptive T cell therapy against tumors
… effect in the past. Most of our work focused on myxoma virus, a rabbit poxvirus, which can efficiently infect various types of mouse and human cancer cells. It is a strict rabbit-specific pathogen, and is thought to be safe as a therapeutic agent in all non-rabbit hosts tested including mice and …
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Myxoma Virus Therapy of Malignant Gliomas in Murine Syngeneic Models: Translating Barriers to Therapy
… the potential immune-effectors mediating Myxoma virus (MYXV) clearance in immunocompetent mouse models. MYXV is a rabbit-specific poxvirus that has oncolytic properties in cancer cell lines, having previously been shown to ‘cure’ human xenograft models. We found that syngeneic murine …
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Molecular Signatures of Adaptation: MHC Evolution and Natural Selection in European Rabbits
… evolutionary changes in natural populations. The myxomatosis pandemic in European rabbits (Oryctolagus cuniculus) provides an unprecedented opportunity to examine MHC-I evolution under intense viral selection. Following the release of myxoma virus as a biological control in 1950s in Australia, …
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Improvement of the Capripoxvirus, lumpy skin disease virus for use as a vaccine vector
… act as SOD decoys, such as the Leporipoxviruses myxoma and Shope Fibroma virus, were observed. Like Leporipoxvirus’ SOD homologues, the full-length Herbivac SOD homologue contained regions of homology with the copper chaperone for SOD (CCS). The putative SOD protein from Herbivac, and not nLSDV, …
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Immunotherapy for murine glioma
… oncolytic poxviruses, vvDD vaccinia virus and myxoma virus, were each engineered to express the fusion protein IL15Ra-IL15 and a fluorescent protein (YFP or tdTomato Red). Viral gene expression (YFP or tdTomato Red) was confirmed in the murine glioma line GL261 in vitro and in vivo. Orthotopic …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… staining. SAMD9 is a host restriction factor for myxoma virus and vaccinia virus. We hypothesize that SAMD9 may have an anti-viral effect against HPV-11, which is still to be determined as we need to establish an efficient in vitro HPV-11 replication model. Due to the possibility that HPVs may …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… staining. SAMD9 is a host restriction factor for myxoma virus and vaccinia virus. We hypothesize that SAMD9 may have an anti-viral effect against HPV-11, which is still to be determined as we need to establish an efficient in vitro HPV-11 replication model. Due to the possibility that HPVs may …
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Interactions of viral and cellular Tumour Necrosis Factor Receptor molecules
… it has previously shown that the rabbit-trophic Myxoma (MYX) viral TNFR also contains a PLAD required for viral TNFR:cellular TNFR interactions, little is known about the human-trophic poxvirus TNFRs, nor physical characteristics of the interactions of vTNFRs and cellular TNFRs. To assess the …
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The Major Histocompatibility Complex in Rabbits
… as evidenced by the coevolution of the myxoma virus (MYXV) and the European rabbit (Oryctolagus cuniculus). The European rabbit, originating from the Iberian Peninsula, has been introduced worldwide, often becoming a pest. MYXV causes myxomatosis, a lethal disease for European rabbits, …
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Vaccine Development Strategies for Crimean-Congo Hemorrhagic Fever Virus and its Tick Vector
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne bunyavirus with an extensive geographic range and complex ecology. Ticks within the Hyalomma genera are the primary vector and reservoir of the virus and maintain the virus through a cryptic tick-vertebrate-tick cycle in nature. However, …