Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Myxoid liposarcoma"”.
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Myxoid Liposarcoma: Models and Mechanisms of Sarcomagenesis and Response to Radiation Therapy
<p>Myxoid liposarcoma (MLPS) is a malignant soft tissue sarcoma characterized by a pathognomonic t(12;16)(q13;p11) translocation that produces a fusion oncoprotein, FUS-CHOP. This cancer is remarkably sensitive to radiotherapy and exhibits a unique pattern of extrapulmonary metastasis. However, the …
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Development of digital PCR probe assays targeting SNPs to monitor co-cultured cell lines
… single nucleotide polymorphisms (SNPs) of each myxoid liposarcoma (MLS) and a fibrosarcoma human-derived cell line. In his thesis, a method was developed for monitoring co-cultures with up to four different cell lines with reliable quantification using dPCR analysis, proving to be both sensitive …
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Molecular analysis of the FET family fusion oncoprotein FUS-DDIT3
… initiating and driving factors of tumorigenesis. Myxoid liposarcoma (MLS) is defined by the t(12;16)(q13;p11) that cause the fusion of the FUS and DDIT3 genes and expression of a chimeric FUS-DDIT3 oncoprotein. The aim of this thesis was to functionally characterize the FUS-DDIT3 fusion …
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Genotype and phenotype in mitochondrial disorders
… find a probably causative somatic insertion in a myxoid liposarcoma. Natural history <br>Natural history studies tend to be small and recruit participants from specialist clinics. Working together with the National Congenital Anomalies and Rare Diseases Registration Service (NCARDRS), we have …