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Showing 1 to 20 of 24 for “"Myxococcus xanthus"”.
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CRISPR3 Regulates Exopolysaccharide Production in Myxococcus xanthus
Myxococcus xanthus, a model organism for studying development and Type IV pili (T4P), harbors three Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) on its chromosome. CRISPR systems, which function as an adaptive immune system in prokaryotes, are classified into three types based …
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Regulation of Exopolysaccharide Production in Myxococcus Xanthus
The surface gliding motility of Myxococcus xanthus is required for a multicellular developmental process initiated by unfavorable growth conditions. One form of the M. xanthus surface motility, social (S) gliding, is mediated by the extension and retraction of polarly localized type IV pili (Tfp). …
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Mathematical modelling of motility regulation in Myxococcus xanthus
Myxococcus xanthus, referred to as a 'social bacterium', demonstrates unique behaviors such as coordinated motility, cooperative feeding, and multicellular structure formation. Its complex social behaviors and developmental processes make M. xanthus a model organism for studying bacterial social …
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Nla28 Activator Modulates σ54-dependent Gene Regulation in Myxococcus xanthus
<p>The complex life cycle of Myxococcus xanthus makes it a model organism for studying multicellular developmental processes in bacteria. In response to environmental changes, M. xanthus cells collectively and dramatically adjust their morphology, physiological functions, and biosynthesis. …
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Multicellular Phenotypic Studies of Single Gene Variants in Myxococcus xanthus
… of 28 genes in the multicellular bacterium <em>Myxococcus xanthus</em> using three different methods: sequence homology, transcription activation and protemoics. The results from this research extended the list of <em>M. xanthus</em> genes involved in multicellularity, and expanded our knowledge …
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Evolution, epistasis, and the genotype-to-phenotype problem in Myxococcus xanthus.
<p>The complex social behavior of M. xanthus makes it an excellent model system to study the relationship between genotype and phenotype. Under nutrient rich conditions, a swarm of M. xanthus cells coordinate their movement outward in search of prey. When starved, cells condense into multicellular …
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Using Deep Learning to Extract Multicellular Aggregation Features of Myxococcus xanthus
… incompletely understood. The bacterium Myxococcus xanthus, known for its intricate aggregation and fruiting body formation under nutrient deprivation, offers a powerful model for studying these dynamics. This thesis addresses both methodological and analytical challenges in studying M. …
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Biosynthesis of Nucleotide Sugar Monomers for Exopolysaccharide Production in Myxococcus Xanthus
Myxococcus xanthus displays social (S) motility, a form of surface motility that is key to the multicellular behaviors of this organism. S motility requires two cellular structures: type IV pili (TFP) and exopolysaccharides (EPS). Previous studies have shown that M. xanthus does not use glucose or …
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Characterisation of the flavin adenine dinucleotide binding region in Myxococcus xanthus protoporphyrinogen oxidase
… of PPOX. In this study the FAD binding region in Myxococcus xanthus PPOX was analysed by engineering and characterising a selection of relevant mutants.
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Novel collective prey evasion response of Pseudomonas aeruginosa PAO1 to soil micropredator Myxococcus xanthus DK1622
… When standardized spots of micropredator <em>Myxococcus xanthus </em>DK1622 and prey were placed 1 millimeter apart on partial starvation media, most prey bacteria such as <em>Escherichia </em>coli K12 and <em>Staphylococcus </em>aureus displayed a three-log reduction in surviving cell counts …
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Resistance Responses in Pseudomonas aeruginosa PAO1 in Response to Surface Predation by Myxococcus xanthus DK1622
… response mechanism for avoiding predators. <em>Myxococcus xanthus</em> is a micropredator for a wide variety of bacteria including clinically relevant human pathogens. We have tested the predatory ability of a laboratory reference strain of <em>M. xanthus </em>DK1622 against <em>P. aeruginosa …
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Investigating the Roles of the Stk Locus in Development, Motility and Exopolysaccharide Production in Myxococcus Xanthus
Myxococcus xanthus, a Gram-negative bacterium with a developmental cycle, displays a type IV pili (TFP) mediated surface motility known as social (S) gliding. Beside the polarly localized TFP, the fibril or extracellular polysaccharide (EPS) is also required for S-motility to function. It is …
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Role of the Nla6S and Nla28S histidine kinases in fruiting body development of <i>Myxococcus xanthus</i>
<p>The complex life cycle of Myxococcus xanthus makes it a model organism for studying multicellular developmental processes in bacteria. In response to adverse environmental conditions, M. xanthus aggregates and forms multicellular structures known as fruiting bodies. Two component signal …
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Demonstration of Interactions Among Dif Proteins and the Identification of Kapb as a Regulator of Exopolysaccharide in Myxococcus Xanthus
Myxococcus xanthus Dif proteins are chemotaxis homologues that regulate exopolysaccharide (EPS) biogenesis. Previous genetic studies suggested that Dif protein might interact with one another as do the chemotaxis proteins in enterics. The interactions among Dif proteins were since investigated with …
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Independence and interdependence: signal transduction of two chemosensory receptors important for the regulation of gliding motility in Myxococcus xanthus
The Myxococcus xanthus Dif and Frz chemosensory pathways play important roles in the regulation of gliding motility. The Dif system regulates the production of exopolysaccheride (EPS), which is essential for social motility and fruiting body formation. The Frz pathway controls reversal frequency, …
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Developing a New Mechanical Model for Swarm Development in Myxococcus xanthus & Establishing a Genotype-to-Phenotype Correlation Between Swarm Pattern Formation and Gene Homology
… formation and wound healing to embryogenesis. Myxococcus xanthus is a soil bacterium used as a model organism to study biofilm self-organization. It has a relatively large genome and a complex life cycle that involves two distinct phases. M. xanthus cells can move on agar, and a few million …
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Expression, purification and characterisation of protoporphyrinogen oxidases from diverse species
… in haem biosynthesis, from Bacillus subtilis, Myxococcus xanthus, and human. A defect in human PPO causes variegate porphyria, an autosomal dominant disorder characterised by skin photosensitivity and propensity towards acute neurovisceral crises. At the beginning of this project little …
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An investigation of intrinsically disordered proteins in Gram-negative bacteria
… absent from the Gram-negative spore-forming Myxococcus xanthus. This is despite the fact that M. xanthus forms spores with enhanced UV resistance compared to their vegetative counterparts. In part I of this thesis, evidence is presented that M. xanthus possesses its own unique set of SASPs …
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Doctoral Research Project : Sustainable production of bacterial polymers
… extraction method was developed, using Myxococcus xanthus as a predatory bacterium to lyse P. aestuariivivens 96 cells, though further improvements are still needed for optimal polymer recovery. Finally, biodegradability testing was conducted on P(3HB), P(3HO-co-3HD-co-3HDD), and two …
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