Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Myositis"”.
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Mitochondrial Biology in Sporadic Inclusion Body Myositis
Sporadic Inclusion Body Myositis (sIBM) is an inflammatory muscle disease that strikes individuals at random and accounts for approximately 1/3 of all idiopathic inflammatory myopathies. It is characterized by progressive weakness of distal and proximal muscles and is the most common muscle …
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Analysis of MRI in the diagnosis of myositis
… inflammatory myopathy IIM (generally called Myositis) isa rare but serious condition characterised by the presence of skeletal muscleinflammation, causing muscle weakness and disability (Targoff 1998,Karpati and Hilton-Jones 2001, Harris-Love 2003, Sultan et al 2002, Plotz1989). There is no …
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HIV-Polymyositis progressing to inclusion body myositis: clues to earlier diagnosis
… Virus (HIV)-positive patients may include polymyositis (PM), dermatomyositis and inclusion body myositis (IBM). Although PM is still mentioned, it is thought to be rare since the discovery of myositis autoantibodies. In the last few years it has been reported that several cases who were …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… the target tissues of the autoimmune disorders myositis and vasculitis, two autoimmune disorders characterised by a wide range of autoantibodies which have been implicated in the pathological mechanisms of these diseases. This study aimed to test the hypothesis that infiltrating B cells within …
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Characterization of the role of the innate immune system in the pathogenesis of chikungunya virus in mice
… mice resulted in an acute illness with severe myositis and inflammation in the skeletal muscle. This was used as a small animal model that aided in the study of the pathogenesis and the immune response of infected animals. By using GFP and luciferase bearing clones of CHIKV, it was found that …
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A Proposed Mechanism for Enhanced Titin-Based Force during Ca2+-activation
… in sarcomeres with muscular dystrophy with myositis (mdm), a genetic mutation affecting the titin protein. The final study seeks to determine whether mechanical deficiencies in titin force enhancement are observed in a less reduced, single fiber preparation. Mutant fibers generated …
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A retrospective study of patients with biologics treatment at Groote Schuur and Red Cross Children's War Memorial Hospitals
… Lupus Erythematosus (SLE) , 5 inflammatory myositis and 5 other conditions); gastroenterology (n=31; 26 Crohn`s and 5 Ulcerative Colitis), dermatology (n=9; psoriasis), neurology (n=4, ophthalmology (n= 25; 6 scleritis, 18 uveitis, 1 optic neuritis), and paediatrics (n= 45, 26 juvenile …
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Expression der Isoformen des „Myosin Heavy Chain“ (neonatal, developmental und fast) sowie N-CAM bei myogenen und neuromuskulären Erkrankungen
… der myopathischen, der neurogenen als auch der myositischen Gewebesyndrome. <br>Ziel ist es, für die pathognomisch unterschiedlichen Erkrankungen anhand der o.g. Reaktionsmuster <br> - die Frage der möglichen Persistenz von MHC-d und –n im Rahmen kongenitaler <br>Myopathien und spinaler …
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Genetic factors in statin intolerance
… associated with increased risk of statin-induced myositis, cases of which had been clinically adjudicated and exome sequenced for the PREDICTION-ADR consortium. Further exploration of the LILR gene region showed an association with variants in LILRB2 (His20Arg and Val235Met) which were in strong …
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Barcoded Transposon Directed Insertion-site Sequencing (TraDIS); a tool to improve our understanding of the functional genomics of Streptococcus equi subsp. equi
… in a non-human primate model of necrotising myositis and in a mouse model of subcutaneous infection, uncovered a set of 23 pan-species fitness genes. Eighteen genes were also commonly identified between the S. equi in vivo data and S. pyogenes ex vivo in human saliva, alluding to the …
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DISSECTING THE MOLECULAR MECHANISMS RELATED TO THE ONSET OF NEUROLOGICAL COMPLICATIONS IN THREE CELLULAR MODELS OF SARS-COV 2 INFECTION: IPSC-DERIVED MOTO R NEURONS, IPSC-DERIVED DOPAMINERGIC NEURONS, IPSC DERIVED-HUMAN CORTICAL ORGANOIDS.
… disorders including Guillain-Barre syndrome and myositis-like muscle injury [2, 4–8], suggesting detrimental effects of SARS-CoV-2 on both the central and peripheral nervous system (CNS, PNS). Multiple studies have shown neuroinflammation in patients with COVID-19, which may underlie these …
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Descripción de pacientes con miopatías inflamatorias en un hospital de cuarto nivel, centro de referencia de enfermedades autoinmunes y reumáticas e n Bogotá, Colombia. 2022-2024
Introducción: Las miopatías inflamatorias, o miositis, son un grupo heterogéneo de desórdenes autoinmunes con manifestaciones clínicas y paraclínicas mixtas, que dictaminan un curso y pronóstico variado según características clínicas y serológicas específicas. En Colombia, contamos con datos de …
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Die Expression von High Mobility Group Box 1 (HMGB1) und dessen Receptor for Advanced Glycation Endproducts (RAGE) als Pathomechanismus der sporadischen Einschlusskörpermyositis
Die sporadische Einschlusskörpermyositis (sIBM) ist eine chronisch progrediente Muskelerkrankung. Im Muskelgewebe von sIBM-Patienten gibt es eine Anhäufung degenerativer Moleküle, inflammatorischer Infiltrate und von Zellstressmolekülen. Ziel der vorliegenden Arbeit war es, einen möglichen …