Global ETD Search
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Showing 1 to 10 of 10 for “"Myosin regulatory light chain"”.
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Orientation of the Cardiac Myosin Regulatory Light Chain Determined by Polarized Fluorescence
The regulatory light chain (RLC) of myosin is a component of the lever arm of the<br/>myosin motor in muscle thick filaments. Phosphorylation of RLC by myosin light<br/>chain kinase (MLCK) modulates the force and speed of muscle contraction, but the mechanisms of RLC‐mediated regulation in striated …
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The influence of myosin regulatory light chain phosphorylation on the contractile performance of fatigued mammalian skeletal muscle
ABSTRACT The myosm regulatory light chain (RLC) of type II fibres is phosphorylated by Ca2+ -calmodulin dependent myosin light chain kinase (skMLCK) during muscular activation. The purpose of this study was to explore the effect of skMLCK gene ablation on the fatigability of mouse skeletal muscles …
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Chemical Biology Tools for Biochemical and Functional Analysis of Myosin Phosphatase
… hypocontractility in AF to dysregulation of myosin light chain phosphatase (MLCP), a holoenzyme composed of a catalytic subunit (PP1cβ) and a regulatory subunit that targets the phosphatase to sarcomeric substrates. PPP1R12C is an atrial-enriched MLCP regulatory subunit that directs PP1cβ to …
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Mechanisms of myosin regulation and function during tissue folding
… by cycles of assembly and disassembly of actin-myosin networks at the cell apex, called pulses. Pulsatile myosin leads to phases of cellular contraction and cell shape stabilization that result in step-wise apical constriction. While many of the key components of the pathway have been …
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Force potentiation as a modulator of contractile performance: Implications for control of skeletal muscle force and energetics of work
… fast hindlimb muscles from wildtype and skeletal myosin light chain kinase knockout (skMLCK-/-) mice that does not express the primary mechanism for PTP: myosin regulatory light chain (RLC) phosphorylation. In contrast to smooth/cardiac muscles where RLC phosphorylation is indispensable, its …
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Development and application of chemical tools for investigating dynamic processes in cell migration
… central to cell migration are presented. Myosin II, an ATPase motor protein required for cell motility, is activated by phosphorylation of the associated myosin regulatory light chain (mRLC) protein at Serl9. To generate a photoactivated mRLC variant that offers control over the timing and …
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Interactions of Smooth Muscle Myosin Filaments with Actin and Myosin Light Chain Kinase: Insights into the Mechanics of Smooth Muscle Contraction
The functional form of smooth muscle myosin (SMM) within cells is the filament. Smooth muscle contraction is thick (myosin) filament-regulated by phosphorylation of the myosin regulatory light chain (RLC). Upon phosphorylation of Serine 19 of the RLC of SMM by myosin light chain kinase (MLCK), SMM …
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Genetic Approaches to Study Tissue Morphogenesis in Drosophila
… organism Drosophila melanogaster. Nonmuscle myosin II (myosin hereafter) has well-established roles in generating contractile force on actin filaments during morphogenetic processes. Myosin activation is regulated by phosphorylation of the myosin regulatory light chain (MRCL, encoded by …
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Mechanisms affecting post-activation potentiation following voluntary isokinetic knee extension
… function, possibly including changes in myosin regulatory light chain (RLC) phosphorylation and increased intracellular Ca2+ release and sensitivity may have contributed to the observed PAP. It is clear from the literature and the results of Study 1 that there is a significant …
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Proteomic investigation of the molecular targets of mycophenolic acid in human cells
… 1, thioredoxin domain-containing protein 12, myosin regulatory light chain 2, and profilin 1), while 5 proteins were down-regulated (protein SET, stathmin, 40S ribosomal protein S12, histone H2B type 1 A, and histone H2B type 1-C/E/F/G/I). Functional annotation tool analysis showed that MPA …