Global ETD Search
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Showing 1 to 6 of 6 for “"Myosin phosphatase"”.
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Chemical Biology Tools for Biochemical and Functional Analysis of Myosin Phosphatase
… hypocontractility in AF to dysregulation of myosin light chain phosphatase (MLCP), a holoenzyme composed of a catalytic subunit (PP1cβ) and a regulatory subunit that targets the phosphatase to sarcomeric substrates. PPP1R12C is an atrial-enriched MLCP regulatory subunit that directs PP1cβ to …
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Purification and characterization of a smooth muscle myosin phosphatase from turkey gizzards
… the reversible phosphorylation of the 20,000 Da myosin light chains (MLC20). The phosphorylation reaction, which is catalyzed by myosin light chain kinase and results in contraction, has been well characterized. In contrast, little is known about the dephosphorylation reaction or the myosin …
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Alternative splicing of the zebrafish myosin phosphatase targeting subunit, MYPT1, produces a novel isoform
<p>Alternative splicing of the zebrafish Myosin Phosphatase Targeting Subunit, MYPT1, produces a novel isoform (TV202). TV202 and the truncated TV202Δ ere shown to form an active complex with Protein Phosphatase 1 β (PP1β) via stress fiber assay. TV202 was also shown to be localized in the …
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Molecular Mechanism of Zipper Interacting Protein Kinase
… of two enzymes; calcium/calmodulin regulated myosin light chain kinase (MLCK) and smooth muscle myosin phosphatase (SMPP-1M) determine the amount of force generated by smooth muscle. The calcium-independent signaling mediated by myosin phosphatase is regulated by several kinases which include …
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Integration of signalling in smooth muscle caveolae
… a contractile process depending on inhibition of myosin phosphatase activity. Here I test whether protein kinase C and Rho-associated kinase-mediated Ca2+ sensitization depends on caveolae using gene disrupted (KO) mice. While the process of Ca2+ sensitization was unaffected by lack of caveolae in …
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Genetic Approaches to Study Tissue Morphogenesis in Drosophila
… organism Drosophila melanogaster. Nonmuscle myosin II (myosin hereafter) has well-established roles in generating contractile force on actin filaments during morphogenetic processes. Myosin activation is regulated by phosphorylation of the myosin regulatory light chain (MRCL, encoded by …